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    Sct secretin [ Mus musculus (house mouse) ]

    Gene ID: 20287, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sctprovided by MGI
    Official Full Name
    secretinprovided by MGI
    Primary source
    MGI:MGI:99466
    See related
    Ensembl:ENSMUSG00000038580 AllianceGenome:MGI:99466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes the precursor of a gastrointestinal peptide hormone of the secretin-glucagon family. The encoded protein is secreted as a prohormone that undergoes proteolytic processing to generate a mature peptide hormone. The mature peptide regulates secretion of gastric acid, biocarbonate ions from pancreatic and biliary duct epithelia and water homeostasis in the gastrointestinal system. Mice lacking the encoded protein display decreased survival of neuroprogenitor cells during early postnatal period and impaired long-term potentiation and spatial learning in adulthood. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may be processed in a similar manner to generate the mature peptide hormone. [provided by RefSeq, Jul 2015]
    Expression
    Biased expression in placenta adult (RPKM 726.5), duodenum adult (RPKM 163.1) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sct in Genome Data Viewer
    Location:
    7 F5; 7 86.59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140858243..140859082, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141278329..141279174, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 7 Neighboring gene cadherin-related family member 5 Neighboring gene STARR-seq mESC enhancer starr_20485 Neighboring gene dopamine receptor D4 Neighboring gene DEAF1, transcription factor Neighboring gene STARR-seq mESC enhancer starr_20486 Neighboring gene predicted gene, 53347

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables digestive hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables digestive hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hormone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in diet induced thermogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular water homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular water homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gastrin-induced gastric acid secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of gastrin-induced gastric acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of pancreatic juice secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of pancreatic juice secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of somatostatin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of somatostatin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of appetite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of appetite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nutrient levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287171.2NP_001274100.1  secretin isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC163434
      Consensus CDS
      CCDS72069.1
      UniProtKB/TrEMBL
      Q3TJJ8, Q80ZS9
      Related
      ENSMUSP00000041519.7, ENSMUST00000046156.13
      Conserved Domains (1) summary
      smart00070
      Location:3258
      GLUCA; Glucagon like hormones
    2. NM_001309439.2NP_001296368.1  secretin isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites in internal exons, including one in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC163434
      Consensus CDS
      CCDS85457.1
      UniProtKB/TrEMBL
      A0A1B0GS37
      Related
      ENSMUSP00000147780.2, ENSMUST00000211667.2
      Conserved Domains (1) summary
      cl27746
      Location:3258
      Hormone_2; Peptide hormone
    3. NM_011328.4NP_035458.1  secretin isoform 2 preproprotein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC163434
      Consensus CDS
      CCDS40184.1
      UniProtKB/Swiss-Prot
      Q08535
      UniProtKB/TrEMBL
      Q3TJJ8, Q3UKU8
      Related
      ENSMUSP00000128729.2, ENSMUST00000167790.3
      Conserved Domains (1) summary
      smart00070
      Location:3258
      GLUCA; Glucagon like hormones

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140858243..140859082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322065.3XP_017177554.1  secretin isoform X1

      UniProtKB/TrEMBL
      A0A1B0GS37
      Conserved Domains (1) summary
      cl27746
      Location:3258
      Hormone_2; Peptide hormone