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    Slc39a8 solute carrier family 39 (metal ion transporter), member 8 [ Mus musculus (house mouse) ]

    Gene ID: 67547, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc39a8provided by MGI
    Official Full Name
    solute carrier family 39 (metal ion transporter), member 8provided by MGI
    Primary source
    MGI:MGI:1914797
    See related
    Ensembl:ENSMUSG00000053897 AllianceGenome:MGI:1914797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zip8; ZIP-8; BIGM103; 4933419D20Rik
    Summary
    Enables zinc:bicarbonate symporter activity. Involved in several processes, including bicarbonate transport; intracellular monoatomic cation homeostasis; and monoatomic cation transmembrane transport. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Used to study left ventricular noncompaction. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIn. Orthologous to human SLC39A8 (solute carrier family 39 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 38.3), placenta adult (RPKM 18.0) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc39a8 in Genome Data Viewer
    Location:
    3 G3; 3 63.04 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135522644..135594333)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135816882..135888572)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mannosidase, beta A, lysosomal Neighboring gene STARR-seq mESC enhancer starr_09062 Neighboring gene ornithine decarboxylase antizyme 2, pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:135244702-135244889 Neighboring gene STARR-positive B cell enhancer ABC_E10216 Neighboring gene STARR-positive B cell enhancer ABC_E829 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Neighboring gene STARR-positive B cell enhancer ABC_E4597 Neighboring gene STARR-positive B cell enhancer ABC_E11220 Neighboring gene STARR-positive B cell enhancer ABC_E1267 Neighboring gene STARR-seq mESC enhancer starr_09070 Neighboring gene STARR-positive B cell enhancer ABC_E8806 Neighboring gene RIKEN cDNA 4933401H06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:135566107-135566408 Neighboring gene predicted gene, 31243 Neighboring gene predicted gene, 18330 Neighboring gene predicted gene 16500

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of arginine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bicarbonate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cadmium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cadmium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cadmium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cadmium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cartilage homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular detoxification of cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular detoxification of cadmium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cobalt ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cobalt ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular manganese ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular monoatomic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular zinc ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in iron ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in iron ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron ion import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of leukocyte adhesion to arterial endothelial cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in manganese ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in manganese ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in manganese ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mercury ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial manganese ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial manganese ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_negative_effect negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_negative_effect negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasma membrane selenite transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in plasma membrane selenite transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in zinc ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in zinc ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zinc ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zinc ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zinc ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zinc ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zinc ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    metal cation symporter ZIP8
    Names
    Zrt- and Irt-like protein 8
    zinc transporter ZIP8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135149.1NP_001128621.1  metal cation symporter ZIP8 precursor

      See identical proteins and their annotated locations for NP_001128621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
      Source sequence(s)
      AC107690, AK016853, AK028215, BY730883
      Consensus CDS
      CCDS17859.1
      UniProtKB/Swiss-Prot
      Q8BTQ3, Q8BUD6, Q91W10, Q9D426, Q9D5V4
      Related
      ENSMUSP00000136634.2, ENSMUST00000180196.8
      Conserved Domains (1) summary
      pfam02535
      Location:126453
      Zip; ZIP Zinc transporter
    2. NM_001135150.1NP_001128622.1  metal cation symporter ZIP8 precursor

      See identical proteins and their annotated locations for NP_001128622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 3 encode the same protein.
      Source sequence(s)
      AC107690, AK028215, CN528304
      Consensus CDS
      CCDS17859.1
      UniProtKB/Swiss-Prot
      Q8BTQ3, Q8BUD6, Q91W10, Q9D426, Q9D5V4
      Related
      ENSMUSP00000128245.2, ENSMUST00000167390.8
      Conserved Domains (1) summary
      pfam02535
      Location:126453
      Zip; ZIP Zinc transporter
    3. NM_026228.5NP_080504.3  metal cation symporter ZIP8 precursor

      See identical proteins and their annotated locations for NP_080504.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same protein.
      Source sequence(s)
      AC107690, AK014895
      Consensus CDS
      CCDS17859.1
      UniProtKB/Swiss-Prot
      Q8BTQ3, Q8BUD6, Q91W10, Q9D426, Q9D5V4
      Related
      ENSMUSP00000080640.4, ENSMUST00000081978.10
      Conserved Domains (1) summary
      pfam02535
      Location:126453
      Zip; ZIP Zinc transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      135522644..135594333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501934.4XP_006501997.1  metal cation symporter ZIP8 isoform X1

      See identical proteins and their annotated locations for XP_006501997.1

      UniProtKB/Swiss-Prot
      Q8BTQ3, Q8BUD6, Q91W10, Q9D426, Q9D5V4
      Related
      ENSMUSP00000029810.6, ENSMUST00000029810.6
      Conserved Domains (1) summary
      pfam02535
      Location:126453
      Zip; ZIP Zinc transporter
    2. XM_006501935.5XP_006501998.1  metal cation symporter ZIP8 isoform X2

      Conserved Domains (1) summary
      cl00437
      Location:126282
      Zip; ZIP Zinc transporter
    3. XM_006501936.5XP_006501999.1  metal cation symporter ZIP8 isoform X3

      Conserved Domains (1) summary
      cl00437
      Location:126283
      Zip; ZIP Zinc transporter
    4. XM_036163248.1XP_036019141.1  metal cation symporter ZIP8 isoform X4

      Conserved Domains (1) summary
      pfam02535
      Location:1246
      Zip; ZIP Zinc transporter