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    exc-1 IRG-type G domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    exc-1
    Official Full Name
    IRG-type G domain-containing protein
    Primary source
    WormBase:WBGene00001362
    Locus tag
    CELE_C46E1.3
    See related
    AllianceGenome:WB:WBGene00001362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Involved in epithelial cell development and regulation of tube size. Predicted to be located in membrane. Is expressed in amphid sheath cell and excretory canal. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See exc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (15470663..15477409, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CRAL-TRIO domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Soluble guanylate cyclase gcy-36 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Facilitation of Endosomal Recycling by an IRG Protein Homolog Maintains Apical Tubule Structure in Caenorhabditis elegans. Grussendorf KA, et al. Genetics, 2016 Aug. PMID 27334269, Free PMC Article
    2. CRIP homologues maintain apical cytoskeleton to regulate tubule size in C. elegans. Tong X, et al. Dev Biol, 2008 May 1. PMID 18384766, Free PMC Article
    3. Tubes and the single C. elegans excretory cell. Buechner M. Trends Cell Biol, 2002 Oct. PMID 12441252
    4. Cystic canal mutants in Caenorhabditis elegans are defective in the apical membrane domain of the renal (excretory) cell. Buechner M, et al. Dev Biol, 1999 Oct 1. PMID 10491271
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to other organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    IRG-type G domain-containing protein
    NP_001024474.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15470663..15477409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029303.2 → NP_001024474.1  IRG-type G domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024474.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTQ6
      Conserved Domains (2) summary
      cd00882
      Location:538 → 655
      Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)
      cl38936
      Location:245 → 377
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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