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    IPA1 putative polyadenylation protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853606, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IPA1
    Official Full Name
    putative polyadenylation protein
    Primary source
    SGD:S000003902
    Locus tag
    YJR141W
    See related
    AllianceGenome:SGD:S000003902; FungiDB:YJR141W; VEuPathDB:YJR141W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin conjugating enzyme binding activity. Involved in negative regulation of protein ubiquitination; positive regulation of mRNA 3'-end processing; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleus. Orthologous to human UBE3D (ubiquitin protein ligase E3D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IPA1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (695906..696949)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene homoserine dehydrogenase Neighboring gene Hir3p Neighboring gene uncharacterized protein Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ipa1 Is an RNA Polymerase II Elongation Factor that Facilitates Termination by Maintaining Levels of the Poly(A) Site Endonuclease Ysh1. Pearson EL, et al. Cell Rep, 2019 Feb 12. PMID 30759400, Free PMC Article
    2. Proteasome Activity Is Influenced by the HECT_2 Protein Ipa1 in Budding Yeast. Lutz AP, et al. Genetics, 2018 May. PMID 29519818, Free PMC Article
    3. Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex. Hill CH, et al. Mol Cell, 2019 Mar 21. PMID 30737185, Free PMC Article
    4. Regulation of the Ysh1 endonuclease of the mRNA cleavage/polyadenylation complex by ubiquitin-mediated degradation. Lee SD, et al. RNA Biol, 2020 May. PMID 32009536, Free PMC Article
    5. An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast. Hansen KG, et al. Science, 2018 Sep 14. PMID 30213914

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative polyadenylation protein
    NP_012675.1
    • Protein implicated in pre-mRNA processing and proteasomal degradation; interacts physically and genetically with mRNA cleavage and polyadenylation factors; mutant is impaired in pre-mRNA cleavage and polyadenylation; associates with several Ub-conjugating enzymes and alters Ub-mediated proteasome activity; localizes to both the nucleus and cytosol; contains a HECT_2 domain; homologous to human ubiquitin-protein ligase, UBE3D, a gene implicated in age-related macular degeneration

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      695906..696949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181799.1 → NP_012675.1  TPA: putative polyadenylation protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012675.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWW0, P47172
      UniProtKB/TrEMBL
      B5VLT0, C7GM72, C8ZBU1, G2WHE4, N1P1B6
      Conserved Domains (1) summary
      COG5629
      Location:4 → 347
      COG5629; Predicted metal-binding protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47172.1

    Gene LinkOut

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