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    BTT1 CCR4-NOT core subunit BTT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851839, updated on 9-Dec-2024

    Summary

    Official Symbol
    BTT1
    Official Full Name
    CCR4-NOT core subunit BTT1
    Primary source
    SGD:S000002660
    Locus tag
    YDR252W
    See related
    AllianceGenome:SGD:S000002660; FungiDB:YDR252W; VEuPathDB:YDR252W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in cotranslational protein targeting to membrane. Part of CCR4-NOT core complex and nascent polypeptide-associated complex. Orthologous to human BTF3 (basic transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See BTT1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (963412..963861)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pam1p Neighboring gene Met32p Neighboring gene Chl4p

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    part_of CCR4-NOT core complex PubMed 
    located_in cytoplasm  
    is_active_in cytosol  
    part_of nascent polypeptide-associated complex  
    part_of nascent polypeptide-associated complex PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    CCR4-NOT core subunit BTT1
    NP_010538.1
    • Heterotrimeric nascent polypeptide-associated complex beta3 subunit; complex binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3; BTT1 has a paralog, EGD1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      963412..963861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180560.1 → NP_010538.1  TPA: CCR4-NOT core subunit BTT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010538.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZYK4, D6VSN2, P40314
      UniProtKB/TrEMBL
      B3LG38, C7GTI7, C8Z5G4, G2WAZ5, N1P6P4
      Conserved Domains (1) summary
      cd22055
      Location:9 → 125
      NAC_BTF3; basal transcription factor BTF3
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