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    asd aspartate-semialdehyde dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947939, updated on 3-Dec-2024

    Summary

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    Official Symbol
    asd
    Official Full Name
    aspartate-semialdehyde dehydrogenase
    Primary source
    ECOCYC:EG10088
    Locus tag
    b3433
    See related
    ASAP:ABE-0011211
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dap; ECK3419; hom
    Summary
    Aspartate semialdehyde dehydrogenase (Asd) carries out the middle step in the pathway of homoserine biosynthesis, generating L-aspartate-semialdehyde. [More information is available at EcoCyc: EG10088].
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    Genomic context

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    Sequence:
    NC_000913.3 (3573775..3574878, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene limit dextrin alpha-1,6-glucohydrolase Neighboring gene 1,4-alpha-glucan branching enzyme Neighboring gene protein YhgO Neighboring gene protein YhgP Neighboring gene MarC family putative inner membrane protein YhgN Neighboring gene low-affinity gluconate transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an essential cysteine in the reaction catalyzed by aspartate-beta-semialdehyde dehydrogenase from Escherichia coli. Karsten WE, et al. Biochim Biophys Acta, 1992 May 22. PMID 1350921
    2. Crystallization and preliminary crystallographic analysis of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli. Kryger G, et al. J Mol Biol, 1992 Nov 5. PMID 1360028
    3. Aspartate-semialdehyde dehydrogenase from Escherichia coli. Cohen GN. Methods Enzymol, 1985. PMID 2868399
    4. Multivalent repression of aspartic semialdehyde dehydrogenase in Escherichia coli K-12. Boy E, et al. J Bacteriol, 1972 Oct. PMID 4404058, Free PMC Article
    5. Aspartate-beta-semialdehyde dehydrogenase from Escherichia coli. Purification and general properties. Biellmann JF, et al. Eur J Biochem, 1980 Feb. PMID 6102909

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that a novel substrate binding interaction was discovered: hydrogen bonding between the substrate and aspartate semialdehyde dehydrogenase (ASADH).
      Title: Synthesis and evaluation of conformationally restricted inhibitors of aspartate semialdehyde dehydrogenase.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate-semialdehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aspartate-semialdehyde dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' L-methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in diaminopimelate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homoserine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lysine biosynthetic process via diaminopimelate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aspartate-semialdehyde dehydrogenase
    NP_417891.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3573775..3574878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417891.1 aspartate-semialdehyde dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417891.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7L7EDZ2
      Conserved Domains (1) summary
      PRK06598
      Location:1 → 366
      PRK06598; aspartate-semialdehyde dehydrogenase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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