snx-1 PX domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: snx-1
Official Full Name: PX domain-containing protein
Primary source: WormBase:WBGene00004927
Locus tag: CELE_C05D9.1
See related: AllianceGenome:WB:WBGene00004927
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in several processes, including mechanosensory behavior; phagosome-lysosome fusion involved in apoptotic cell clearance; and protein localization to postsynaptic membrane. Located in early endosome and early phagosome. Is expressed in several structures, including arcade cell; head; head mesodermal cell; pharynx; and reproductive system. Orthologous to human SNX1 (sorting nexin 1) and SNX2 (sorting nexin 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See snx-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (1128986..1132711)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

snx-1 functions cell autonomously within glia to promote sensory compartment growth, and SNX-1 protein is enriched near the surface of the sensory compartment.
Title: Some, but not all, retromer components promote morphogenesis of C. elegans sensory compartments.
LST-4 and SNX-1 promote the extension of phagosomal tubules to facilitate the docking and fusion of intracellular vesicles.
Title: Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05D9.1 (e-PCR)
- UniSTS:313472

STS6-220 (e-PCR)
- UniSTS:242606

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in early endosome to Golgi transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagolysosome assembly involved in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome maturation involved in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome-lysosome fusion involved in apoptotic cell clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagosome-lysosome fusion involved in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early phagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PX domain-containing protein

NP_508216.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

1128986..1132711

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075815.8 → NP_508216.1 PX domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508216.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9GYJ9

Conserved Domains (2) summary

cd07623
Location:243 → 468

BAR_SNX1_2; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 1 and 2

cl02563
Location:91 → 214

PX_domain; The Phox Homology domain, a phosphoinositide binding module