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    mcm-2 DNA replication licensing factor MCM2 [ Caenorhabditis elegans ]

    Gene ID: 174841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mcm-2
    Official Full Name
    DNA replication licensing factor MCM2
    Primary source
    WormBase:WBGene00003154
    Locus tag
    CELE_Y17G7B.5
    See related
    AllianceGenome:WB:WBGene00003154
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable single-stranded DNA binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication; double-strand break repair via break-induced replication; and mitotic DNA replication initiation. Located in condensed chromosome and pronucleus. Is expressed in excretory cell; intestine; nervous system; reproductive system; and seam cell. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mcm-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (12001509..12006625, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene B30.2/SPRY domain-containing protein;Set1/Ash2 histone methyltransferase complex subunit ash-2 Neighboring gene hydroxyacylglutathione hydrolase Neighboring gene Deoxyhypusine synthase Neighboring gene Activin_recp domain-containing protein;DUF281 domain-containing protein Neighboring gene Globin domain-containing protein Neighboring gene ncRNA Neighboring gene RNA exonuclease 4 Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Minichromosome maintenance protein 5 homologue in Caenorhabditis elegans plays essential role for postembryonic development. Wang X, et al. Biochem Biophys Res Commun, 2007 Aug 10. PMID 17568563
    2. Http://C. elegans: mining the functional genomic landscape. Kim SK. Nat Rev Genet, 2001 Sep. PMID 11533717
    3. RbAp46/48LIN-53 and HAT-1 are required for initial CENP-AHCP-3 deposition and de novo holocentromere formation on artificial chromosomes in Caenorhabditis elegans embryos. Lin Z, et al. Nucleic Acids Res, 2021 Sep 20. PMID 33872374, Free PMC Article
    4. The dynamics of replication licensing in live Caenorhabditis elegans embryos. Sonneville R, et al. J Cell Biol, 2012 Jan 23. PMID 22249291, Free PMC Article
    5. PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo. Benkemoun L, et al. J Cell Biol, 2014 May 26. PMID 24841566, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MCM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM2
    NP_001022416.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12001509..12006625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027245.8 → NP_001022416.1  DNA replication licensing factor MCM2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022416.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XXI9
      Conserved Domains (4) summary
      cd00009
      Location:461 → 639
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00350
      Location:270 → 777
      MCM; minichromosome maintenance proteins
      pfam12619
      Location:48 → 103
      MCM2_N; Mini-chromosome maintenance protein 2
      pfam14551
      Location:171 → 286
      MCM_N; MCM N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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