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    Taok2 TAO kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 381921, updated on 9-Dec-2024

    Summary

    Official Symbol
    Taok2provided by MGI
    Official Full Name
    TAO kinase 2provided by MGI
    Primary source
    MGI:MGI:1915919
    See related
    Ensembl:ENSMUSG00000059981 AllianceGenome:MGI:1915919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSK; PSK1; TAO1; TAO2; MAP3K17; mKIAA0881; B230344N16; 1110033K02Rik
    Summary
    Enables neuropilin binding activity. Involved in neuron projection morphogenesis; positive regulation of JNK cascade; and regulation of actin cytoskeleton organization. Located in axonal growth cone and dendritic growth cone. Colocalizes with actin cytoskeleton. Is expressed in central nervous system and retina. Orthologous to human TAOK2 (TAO kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 32.8), ovary adult (RPKM 27.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Taok2 in Genome Data Viewer
    Location:
    7 F3; 7 69.25 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126464848..126485468, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126865674..126886296, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene double C2, alpha Neighboring gene INO80 complex subunit E Neighboring gene STARR-positive B cell enhancer ABC_E8843 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134005673-134005856 Neighboring gene HIRA interacting protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E2849 Neighboring gene transmembrane protein 219 Neighboring gene predicted gene, 23445 Neighboring gene STARR-positive B cell enhancer ABC_E10477 Neighboring gene potassium channel tetramerisation domain containing 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation
    • Transgenic (1) 

    Interactions

    General gene information

    Clone Names

    • KIAA0881

    Gene Ontology Provided by MGI

    Items 1 - 25 of 31
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables MAP kinase kinase kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables mitogen-activated protein kinase kinase binding  
    enables mitogen-activated protein kinase kinase binding  
    enables neuropilin binding PubMed 
    enables neuropilin binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 31
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in MAPK cascade  
    involved_in MAPK cascade  
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in axonogenesis PubMed 
    involved_in axonogenesis PubMed 
    involved_in axonogenesis  
    involved_in basal dendrite arborization PubMed 
    involved_in basal dendrite arborization  
    involved_in basal dendrite morphogenesis PubMed 
    involved_in basal dendrite morphogenesis  
    involved_in chromatin remodeling  
    involved_in focal adhesion assembly  
    involved_in focal adhesion assembly  
    involved_in mitotic G2 DNA damage checkpoint signaling  
    involved_in mitotic G2 DNA damage checkpoint signaling  
    involved_in neuron projection morphogenesis  
    involved_in positive regulation of JNK cascade PubMed 
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of stress-activated MAPK cascade  
    involved_in positive regulation of stress-activated MAPK cascade  
    involved_in regulation of MAPK cascade  
    involved_in regulation of actin cytoskeleton organization PubMed 
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    involved_in regulation of postsynapse organization  
    involved_in regulation of synaptic membrane adhesion  
    involved_in stress-activated MAPK cascade  
    involved_in stress-activated MAPK cascade  
    Items 1 - 25 of 32
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton PubMed 
    located_in axon PubMed 
    located_in axonal growth cone PubMed 
    is_active_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle membrane  
    located_in cytosol  
    located_in cytosol  
    located_in dendritic growth cone PubMed 
    is_active_in glutamatergic synapse  
    located_in neuron projection PubMed 
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in postsynapse  
    part_of receptor complex PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase TAO2
    Names
    TAO kinase 2TAO kinase 2
    thousand and one amino acid protein 2
    NP_001157246.1
    NP_001157247.1
    XP_030098581.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163774.2NP_001157246.1  serine/threonine-protein kinase TAO2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AC122863, AC124505
      Consensus CDS
      CCDS52404.1
      UniProtKB/Swiss-Prot
      Q6ZQ29
      Related
      ENSMUSP00000071246.5, ENSMUST00000071268.11
      Conserved Domains (2) summary
      COG0419
      Location:481920
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06634
      Location:12319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2
    2. NM_001163775.2NP_001157247.1  serine/threonine-protein kinase TAO2 isoform 2

      See identical proteins and their annotated locations for NP_001157247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AC122863, AC124505
      Consensus CDS
      CCDS52403.1
      UniProtKB/Swiss-Prot
      Q6ZQ29, Q7TSS8
      Related
      ENSMUSP00000112963.2, ENSMUST00000117394.2
      Conserved Domains (2) summary
      smart00220
      Location:28281
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06634
      Location:12319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126464848..126485468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242721.2XP_030098581.1  serine/threonine-protein kinase TAO2 isoform X1

      Conserved Domains (2) summary
      COG0419
      Location:481920
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06634
      Location:12319
      STKc_TAO2; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2

    RNA

    1. XR_001785578.3 RNA Sequence

    2. XR_003946498.1 RNA Sequence

    3. XR_001785580.1 RNA Sequence

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