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    Prkca protein kinase C, alpha [ Mus musculus (house mouse) ]

    Gene ID: 18750, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prkcaprovided by MGI
    Official Full Name
    protein kinase C, alphaprovided by MGI
    Primary source
    MGI:MGI:97595
    See related
    Ensembl:ENSMUSG00000050965 AllianceGenome:MGI:97595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pkca
    Summary
    Enables calcium,diacylglycerol-dependent serine/threonine kinase activity; integrin binding activity; and lipid binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of bone resorption; and positive regulation of dense core granule biogenesis. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of signal transduction; and regulation of protein phosphorylation. Located in several cellular components, including cone photoreceptor outer segment; intercalated disc; and ooplasm. Part of alphav-beta3 integrin-PKCalpha complex. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 19.9), cortex adult (RPKM 11.1) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Prkca in Genome Data Viewer
    Location:
    11 E1; 11 70.8 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (107824213..108237360, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (107933387..108343888, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 4 Neighboring gene predicted gene 11650 Neighboring gene calcium channel, voltage-dependent, gamma subunit 5 Neighboring gene STARR-seq mESC enhancer starr_30997 Neighboring gene STARR-seq mESC enhancer starr_30998 Neighboring gene predicted gene 11657 Neighboring gene microRNA 7223 Neighboring gene predicted gene, 51922 Neighboring gene predicted gene 11655 Neighboring gene STARR-seq mESC enhancer starr_31000 Neighboring gene STARR-seq mESC enhancer starr_31001 Neighboring gene predicted gene, 36709 Neighboring gene apolipoprotein H

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity PubMed 
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity PubMed 
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity  
    enables diacylglycerol-dependent serine/threonine kinase activity PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity  
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity  
    enables enzyme binding  
    enables histone H3T6 kinase activity  
    enables integrin binding PubMed 
    enables lipid binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables zinc ion binding  
    Items 1 - 25 of 75
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in cell adhesion  
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within cellular response to carbohydrate stimulus PubMed 
    involved_in central nervous system neuron axonogenesis  
    acts_upstream_of_or_within chondrocyte differentiation PubMed 
    involved_in desmosome assembly  
    acts_upstream_of_or_within induction of positive chemotaxis PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis PubMed 
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway PubMed 
    involved_in learning or memory  
    acts_upstream_of_or_within muscle cell cellular homeostasis PubMed 
    acts_upstream_of_or_within negative regulation of D-glucose import PubMed 
    acts_upstream_of_or_within negative regulation of MAPK cascade PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of glial cell apoptotic process  
    involved_in negative regulation of glial cell apoptotic process  
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of protein kinase activity PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation PubMed 
    involved_in negative regulation of translation  
    acts_upstream_of_or_within neutrophil chemotaxis PubMed 
    acts_upstream_of_or_within peptidyl-serine autophosphorylation PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiotensin-activated signaling pathway  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of bone resorption PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of dense core granule biogenesis PubMed 
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of exocytosis  
    acts_upstream_of_or_within positive regulation of inflammatory response PubMed 
    involved_in positive regulation of lipopolysaccharide-mediated signaling pathway  
    involved_in positive regulation of lipopolysaccharide-mediated signaling pathway  
    involved_in positive regulation of macrophage differentiation PubMed 
    involved_in positive regulation of mitotic cell cycle  
    involved_in positive regulation of mitotic cell cycle  
    acts_upstream_of_or_within positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of synapse assembly  
    involved_in post-translational protein modification  
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    acts_upstream_of protein phosphorylation PubMed 
    acts_upstream_of protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    acts_upstream_of_or_within regulation of muscle contraction PubMed 
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in regulation of platelet aggregation PubMed 
    involved_in regulation of platelet aggregation  
    involved_in regulation of receptor-mediated endocytosis  
    involved_in regulation of synaptic vesicle exocytosis PubMed 
    involved_in regulation of synaptic vesicle exocytosis PubMed 
    acts_upstream_of_or_within regulation of the force of heart contraction PubMed 
    involved_in response to estradiol  
    involved_in response to ethanol  
    involved_in response to interleukin-1  
    involved_in response to reactive oxygen species  
    acts_upstream_of_or_within stem cell differentiation PubMed 
    Items 1 - 25 of 75
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    part_of alphav-beta3 integrin-PKCalpha complex PubMed 
    located_in apical part of cell PubMed 
    located_in axon PubMed 
    is_active_in calyx of Held PubMed 
    is_active_in calyx of Held PubMed 
    is_active_in ciliary basal body  
    located_in cone photoreceptor outer segment PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in endoplasmic reticulum  
    located_in intercalated disc PubMed 
    located_in membrane PubMed 
    located_in mitochondrial membrane  
    located_in mitochondrion PubMed 
    located_in neuronal cell body PubMed 
    located_in nucleus PubMed 
    located_in ooplasm PubMed 
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    is_active_in presynaptic cytosol PubMed 
    part_of protein-containing complex PubMed 
    part_of protein-containing complex  
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    protein kinase C alpha type
    Names
    PKC-A
    PKC-alpha
    protein kinase c-alpha
    NP_035231.2
    XP_036012317.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011101.3NP_035231.2  protein kinase C alpha type

      See identical proteins and their annotated locations for NP_035231.2

      Status: VALIDATED

      Source sequence(s)
      AK147084, AL645535, BF455952
      Consensus CDS
      CCDS25573.1
      UniProtKB/Swiss-Prot
      P20444
      UniProtKB/TrEMBL
      Q4VA93
      Related
      ENSMUSP00000062392.5, ENSMUST00000059595.11
      Conserved Domains (4) summary
      cd04026
      Location:159289
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05615
      Location:328668
      STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
      cd20833
      Location:3592
      C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cd20836
      Location:102155
      C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      107824213..108237360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156424.1XP_036012317.1  protein kinase C alpha type isoform X1

      UniProtKB/Swiss-Prot
      P20444
      Conserved Domains (4) summary
      cd04026
      Location:159289
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05615
      Location:328684
      STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
      cd20833
      Location:3592
      C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cd20836
      Location:102155
      C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
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