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    DCTN3-p24 Dynactin 3, p24 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DCTN3-p24provided by FlyBase
    Official Full Name
    Dynactin 3, p24 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010622
    Locus tag
    Dmel_CG9893
    See related
    AllianceGenome:FB:FBgn0010622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9893; DCTN3; Dmel\CG9893; l(2)06 496; l(2)06496; p22/p24; p24; P24
    Summary
    Involved in regulation of hemocyte proliferation. Predicted to be part of dynactin complex. Is expressed in organism. Orthologous to human DCTN3 (dynactin subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DCTN3-p24 in Genome Data Viewer
    Location:
    59C2-59C3; 2-102 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23061420..23062593, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18948943..18950116, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene twist Neighboring gene uncharacterized protein Neighboring gene Fatty acid transport protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Prophenoloxidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein. Hammesfahr B, et al. BMC Evol Biol, 2012 Jun 22. PMID 22726940, Free PMC Article
    2. Lissencephaly-1 promotes the recruitment of dynein and dynactin to transported mRNAs. Dix CI, et al. J Cell Biol, 2013 Aug 5. PMID 23918939, Free PMC Article
    3. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Eckley DM, et al. Mol Biol Cell, 2003 Jul. PMID 12857853, Free PMC Article
    4. Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam. Yang JS, et al. PLoS One, 2008. PMID 18946501, Free PMC Article
    5. Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. Wilczynski B, et al. PLoS Comput Biol, 2012. PMID 23236268, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynactin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynactin 3, p24 subunit
    Names
    CG9893-PA
    CG9893-PB
    DCTN3-p24-PA
    DCTN3-p24-PB
    Dynactin3 p24
    dynactin, p24 subunit
    lethal (2) 06496
    lethal-(2)06 496

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23061420..23062593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274219.1 → NP_001261148.1  dynactin 3, p24 subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261148.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0AQB0, A0AQB7, Q9W1V8
      Conserved Domains (1) summary
      pfam07426
      Location:7 → 174
      Dynactin_p22; Dynactin subunit p22

    2. NM_143779.4 → NP_652036.1  dynactin 3, p24 subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652036.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0AQB0, A0AQB7, Q9W1V8
      Related
      FBpp0071894
      Conserved Domains (1) summary
      pfam07426
      Location:7 → 174
      Dynactin_p22; Dynactin subunit p22
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1V8 Q9W1V8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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