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    COX6AL Cytochrome c oxidase subunit 6A-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX6ALprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 6A-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050093
    Locus tag
    Dmel_CG30093
    See related
    AllianceGenome:FB:FBgn0050093
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30093; COXD; COXE; Dmel\CG30093; NEST:bs02a12
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 18. Orthologous to human COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See COX6AL in Genome Data Viewer
    Location:
    52D3-52D4; 2-76 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15944028..15944567)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11831533..11832072)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene bunker gear Neighboring gene Myelodysplasia/myeloid leukemia factor Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4aa1 Neighboring gene mir-4919 stem loop Neighboring gene Stretchin-Mlck Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sexually Antagonistic Mitonuclear Coevolution in Duplicate Oxidative Phosphorylation Genes. Havird JC, et al. Integr Comp Biol, 2019 Oct 1. PMID 30942855
    2. Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster. Iyer J, et al. Nat Commun, 2018 Jun 29. PMID 29959322, Free PMC Article
    3. Drosophila Charcot-Marie-Tooth Disease Models. Yamaguchi M, et al. Adv Exp Med Biol, 2018. PMID 29951817
    4. Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. Walls SM Jr, et al. PLoS Genet, 2013. PMID 24339790, Free PMC Article
    5. Recent Advances in Drosophila Models of Charcot-Marie-Tooth Disease. Kitani-Morii F, et al. Int J Mol Sci, 2020 Oct 8. PMID 33049996, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 6A-like
    Names
    CG30093-PA
    COX6AL-PA
    cytochrome c oxidase polypeptide VIA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15944028..15944567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166124.4 → NP_725504.1  cytochrome c oxidase subunit 6A-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725504.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QPY7
      Related
      FBpp0086341
      Conserved Domains (1) summary
      cd00925
      Location:14 → 87
      Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QPY7 Q4QPY7

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