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    Prodh proline dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 19125, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prodhprovided by MGI
    Official Full Name
    proline dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:97770
    See related
    Ensembl:ENSMUSG00000003526 AllianceGenome:MGI:97770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pro1; Pro-1; Ym24d07
    Summary
    Predicted to enable FAD binding activity; amino acid binding activity; and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate and regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Located in mitochondrion. Is expressed in several structures, including adipose tissue; cardiovascular system; central nervous system; forelimb bud; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 99.9), kidney adult (RPKM 99.6) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Prodh in Genome Data Viewer
    Location:
    16 A3; 16 11.19 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17889593..17907147, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18071726..18089283, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 49580 Neighboring gene DiGeorge syndrome critical region gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18075403-18075586 Neighboring gene predicted gene, 52241 Neighboring gene reticulon 4 receptor Neighboring gene predicted gene, 53937

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Spontaneous (1)  1 citation
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC159030

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables amino acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proline dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    proline dehydrogenase 1, mitochondrial
    Names
    proline dehydrogenase, mitochondrial
    proline oxidase
    NP_035302.2
    XP_006521926.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011172.3NP_035302.2  proline dehydrogenase 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_035302.2

      Status: VALIDATED

      Source sequence(s)
      AC087064
      Consensus CDS
      CCDS37278.1
      UniProtKB/Swiss-Prot
      A0JLW6, Q3UNR4, Q9QX61, Q9WU79
      UniProtKB/TrEMBL
      A0A0R4J1T9
      Related
      ENSMUSP00000003620.6, ENSMUST00000003620.13
      Conserved Domains (2) summary
      PLN02681
      Location:47594
      PLN02681; proline dehydrogenase
      pfam01619
      Location:343570
      Pro_dh; Proline dehydrogenase

    RNA

    1. NR_189733.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087064

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17889593..17907147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521863.2XP_006521926.1  proline dehydrogenase 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006521926.1

      Conserved Domains (1) summary
      cl33545
      Location:88516
      PutA_N; Proline utilization A N-terminal domain

    RNA

    1. XR_001781795.1 RNA Sequence