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    Zfp574 zinc finger protein 574 [ Mus musculus (house mouse) ]

    Gene ID: 232976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp574provided by MGI
    Official Full Name
    zinc finger protein 574provided by MGI
    Primary source
    MGI:MGI:2442951
    See related
    Ensembl:ENSMUSG00000045252 AllianceGenome:MGI:2442951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf574; A630056B21Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and limb. Orthologous to human ZNF574 (zinc finger protein 574). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 59.4), ovary adult (RPKM 14.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp574 in Genome Data Viewer
    Location:
    7 A3; 7 13.73 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24775099..24782917)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25075674..25083492)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4905 Neighboring gene microRNA 7046 Neighboring gene Rab acceptor 1 (prenylated) Neighboring gene ATPase, Na+/K+ transporting, alpha 3 polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25785259-25785485 Neighboring gene microRNA 7047 Neighboring gene glutamate receptor, ionotropic, kainate 5 (gamma 2) Neighboring gene STARR-seq mESC enhancer starr_18288 Neighboring gene STARR-positive B cell enhancer ABC_E3704 Neighboring gene POU domain, class 2, transcription factor 2 Neighboring gene microRNA 6537 Neighboring gene STARR-seq mESC enhancer starr_18291 Neighboring gene STARR-positive B cell enhancer ABC_E2225 Neighboring gene STARR-positive B cell enhancer ABC_E6522 Neighboring gene STARR-positive B cell enhancer ABC_E3705 Neighboring gene RIKEN cDNA D930028M14 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Zhong X, et al. Proc Natl Acad Sci U S A, 2024 Jul 30. PMID 39047044,
    2. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
      Title: Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 574

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168506.2 → NP_001161978.1  zinc finger protein 574

      See identical proteins and their annotated locations for NP_001161978.1

      Status: VALIDATED

      Source sequence(s)
      AC125468, AK143997, BC059044
      Consensus CDS
      CCDS20971.1
      UniProtKB/Swiss-Prot
      Q3TDE5, Q3UNU1, Q8BKB5, Q8BY46
      Conserved Domains (2) summary
      COG5048
      Location:498 → 852
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_175477.5 → NP_780686.1  zinc finger protein 574

      See identical proteins and their annotated locations for NP_780686.1

      Status: VALIDATED

      Source sequence(s)
      AC125468, AK143997, BC059044, BY087218
      Consensus CDS
      CCDS20971.1
      UniProtKB/Swiss-Prot
      Q3TDE5, Q3UNU1, Q8BKB5, Q8BY46
      Related
      ENSMUSP00000057817.10, ENSMUST00000053410.11
      Conserved Domains (2) summary
      COG5048
      Location:498 → 852
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24775099..24782917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539850.3 → XP_006539913.1  zinc finger protein 574 isoform X1

      Conserved Domains (2) summary
      COG5048
      Location:541 → 895
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:543 → 563
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006539852.5 → XP_006539915.1  zinc finger protein 574 isoform X2

      See identical proteins and their annotated locations for XP_006539915.1

      UniProtKB/Swiss-Prot
      Q3TDE5, Q3UNU1, Q8BKB5, Q8BY46
      Conserved Domains (2) summary
      COG5048
      Location:498 → 852
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BY46.1 GenPept UniProtKB/Swiss-Prot:Q8BY46

    Gene LinkOut

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