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    Dkk3 dickkopf WNT signaling pathway inhibitor 3 [ Mus musculus (house mouse) ]

    Gene ID: 50781, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dkk3provided by MGI
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 3provided by MGI
    Primary source
    MGI:MGI:1354952
    See related
    Ensembl:ENSMUSG00000030772 AllianceGenome:MGI:1354952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dkk-3; mDkk-3
    Summary
    Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in negative regulation of DNA-templated transcription; negative regulation of canonical Wnt signaling pathway; and negative regulation of steroid hormone biosynthetic process. Located in extracellular space. Is expressed in several structures, including brain; cardiovascular system; limb; sensory organ; and tooth. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 37.0), bladder adult (RPKM 29.9) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dkk3 in Genome Data Viewer
    Location:
    7 F1; 7 58.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (111715226..111758689, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (112116019..112159482, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3960 Neighboring gene ubiquitin specific peptidase 47 Neighboring gene STARR-positive B cell enhancer ABC_E10463 Neighboring gene STARR-seq mESC enhancer starr_19852 Neighboring gene STARR-positive B cell enhancer ABC_E6587 Neighboring gene predicted gene, 39071 Neighboring gene predicted gene, 39070

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables co-receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    dickkopf-related protein 3
    Names
    dickkopf homolog 3
    dickkopf-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360257.1NP_001347186.1  dickkopf-related protein 3 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC122343, FO707532
    2. NM_001360260.1NP_001347189.1  dickkopf-related protein 3 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC122343, AC166834
      Consensus CDS
      CCDS21752.1
      UniProtKB/Swiss-Prot
      Q9QUN9
      Conserved Domains (1) summary
      pfam04706
      Location:147196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    3. NM_001360261.1NP_001347190.1  dickkopf-related protein 3 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AC122343, AC166834
      Conserved Domains (1) summary
      pfam04706
      Location:119168
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    4. NM_015814.3NP_056629.1  dickkopf-related protein 3 isoform b precursor

      See identical proteins and their annotated locations for NP_056629.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC166834, AK004853
      Consensus CDS
      CCDS21752.1
      UniProtKB/Swiss-Prot
      Q9QUN9
      Related
      ENSMUSP00000033036.6, ENSMUST00000033036.7
      Conserved Domains (1) summary
      pfam04706
      Location:147196
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      111715226..111758689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)