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    ZNF776 zinc finger protein 776 [ Homo sapiens (human) ]

    Gene ID: 284309, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZNF776provided by HGNC
    Official Full Name
    zinc finger protein 776provided by HGNC
    Primary source
    HGNC:HGNC:26765
    See related
    Ensembl:ENSG00000152443 AllianceGenome:HGNC:26765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 5.3), lymph node (RPKM 4.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF776 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57746815..57758148)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60843753..60855084)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58258183..58269516)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904783 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58238691-58239191 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58239145-58239370 Neighboring gene zinc finger protein 671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15157 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58280768-58281307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15159 Neighboring gene zinc finger protein 586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58297126-58297745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58297746-58298364 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58300764-58300910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58309809-58310356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15160 Neighboring gene Sharpr-MPRA regulatory region 649 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58314953-58315566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58322897-58323548 Neighboring gene zinc finger protein 552

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ30886, FLJ38288, DKFZp781G1213, DKFZp686K10134

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052796.1 RefSeqGene

      Range
      5020..16353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348007.2NP_001334936.1  zinc finger protein 776 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice structure in its 3' coding region, resulting in a translational frameshift and shorter 3' UTR, compared to variant 1. The encoded isoform (2) is substantially shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK127764, AK299680, BX105932, DA534001
      UniProtKB/Swiss-Prot
      Q68DI1
      UniProtKB/TrEMBL
      B4DSC6
      Conserved Domains (1) summary
      pfam01352
      Location:1354
      KRAB; KRAB box
    2. NM_173632.4NP_775903.3  zinc finger protein 776 isoform 1

      See identical proteins and their annotated locations for NP_775903.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI446541, AK127764, AK299680, BC136753, CR936802
      Consensus CDS
      CCDS12962.2
      UniProtKB/Swiss-Prot
      Q68DI1, Q6ZS36, Q8N968
      Related
      ENSP00000321812.5, ENST00000317178.10
      Conserved Domains (5) summary
      smart00349
      Location:1455
      KRAB; krueppel associated box
      COG5048
      Location:291439
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:322342
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam13465
      Location:390415
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_145326.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon structure near its 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK127764, AK299680, BX105932, DA534001
    2. NR_145327.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon structure near its 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK127764, AK299680, BX105932, CR936802, DA534001
    3. NR_145328.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AK127764, BX105932, HY045891

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57746815..57758148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60843753..60855084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)