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    RPL24 ribosomal protein L24 [ Homo sapiens (human) ]

    Gene ID: 6152, updated on 9-Dec-2024

    Summary

    Official Symbol
    RPL24provided by HGNC
    Official Full Name
    ribosomal protein L24provided by HGNC
    Primary source
    HGNC:HGNC:10325
    See related
    Ensembl:ENSG00000114391 MIM:604180; AllianceGenome:HGNC:10325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L24; eL24; HEL-S-310
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24E family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as ribosomal protein L30 because the encoded protein shares amino acid identity with the L30 ribosomal proteins from S. cerevisiae; however, its official name is ribosomal protein L24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 885.8), endometrium (RPKM 419.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RPL24 in Genome Data Viewer
    Location:
    3q12.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (101681091..101686718, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (104393768..104399383, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101399935..101405562, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 11 Neighboring gene RNY1 pseudogene 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:101392720-101393220 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101395114-101395668 Neighboring gene endogenous retrovirus group K member 5 Gag polyprotein Neighboring gene ZBTB11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20173 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:101405139-101406338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101406769-101407322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101407323-101407876 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:101418343-101419102 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:101419863-101420622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:101420623-101421381 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:101421445-101422644 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101422701-101423652 Neighboring gene uncharacterized LOC124909402 Neighboring gene PDCL3 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L24 (RPL24), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L24 (RPL24), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L24 (RPL24), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L24 (RPL24), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables cadherin binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in exit from mitosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in optic nerve development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retinal ganglion cell axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosomal large subunit assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    large ribosomal subunit protein eL24
    Names
    60S ribosomal protein L24
    60S ribosomal protein L30
    epididymis secretory protein Li 310
    ribosomal protein L30

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000986.4NP_000977.1  large ribosomal subunit protein eL24

      See identical proteins and their annotated locations for NP_000977.1

      Status: REVIEWED

      Source sequence(s)
      BU754101, CD513036, M94314
      Consensus CDS
      CCDS33809.1
      UniProtKB/Swiss-Prot
      B2R4Y3, P38663, P83731, Q6IBS3
      UniProtKB/TrEMBL
      A0A994J4A5, V9HW01
      Related
      ENSP00000377640.3, ENST00000394077.8
      Conserved Domains (1) summary
      pfam01246
      Location:264
      Ribosomal_L24e; Ribosomal protein L24e

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      101681091..101686718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      104393768..104399383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)