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    MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens (human) ]

    Gene ID: 5599, updated on 3-Dec-2024

    Summary

    Official Symbol
    MAPK8provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 8provided by HGNC
    Primary source
    HGNC:HGNC:6881
    See related
    Ensembl:ENSG00000107643 MIM:601158; AllianceGenome:HGNC:6881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in brain (RPKM 9.4), thyroid (RPKM 7.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAPK8 in Genome Data Viewer
    Location:
    10q11.22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (48306677..48439360)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (49155699..49288442)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (49514720..49647403)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:49394772-49395971 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49397051-49398006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3329 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49441449-49441950 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49450548-49450771 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:49455107-49455608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49495838-49496338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2355 Neighboring gene ribosomal protein S6 pseudogene 14 Neighboring gene Sharpr-MPRA regulatory region 12210 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:49607374-49608116 Neighboring gene Sharpr-MPRA regulatory region 2186 Neighboring gene Sharpr-MPRA regulatory region 5880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49653211-49654112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49662087-49663064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49668057-49668559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49671373-49672306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49672307-49673238 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49674919-49675115 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49678026-49678908 Neighboring gene Rho GTPase activating protein 22 Neighboring gene Sharpr-MPRA regulatory region 4601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49686951-49687608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49687609-49688265 Neighboring gene Sharpr-MPRA regulatory region 14185 Neighboring gene ARHGAP22 intronic transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49716013-49716998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49725473-49726106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49727221-49727810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49727811-49728398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2356 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:49741600-49742140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49750999-49751784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49763487-49763987 Neighboring gene NANOG hESC enhancer GRCh37_chr10:49782573-49783074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3331 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:49802653-49803477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49807300-49807800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49812539-49813269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3336 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:49887725-49887989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49893168-49893708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49953319-49953863 Neighboring gene WDFY family member 4 Neighboring gene ribosomal protein L13a pseudogene 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env gp120 upregulates MAPK8 (JNK) in SVGA cells, human fetal astrocytes, and the prefrontal cortex of gp120 transgenic mice PubMed
    env HIV-1 gp120-induced upregulation of APP protein production involves JNK MAPK signaling pathway in human cells PubMed
    env Pretreatment of CD4+ T cells with HIV-1 gp120 followed by stimulation with jacalin results in marked inhibition of phosphorylation of ERK2 as well as JNK PubMed
    env NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response PubMed
    env HIV-1 Env-pseudotyped virus-infected MDM cells induce cellular apoptosis through reactive oxygen species (ROS) generation and JNK phosphorylation PubMed
    env CCR5 and CXCR4 coreceptor engagement by HIV-1 gp120 in primary macrophages activates 2 members of the mitogen-activated protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase and p38 MAPK PubMed
    env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
    env HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells PubMed
    env Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB PubMed
    env HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in primary human central nervous system (CNS) cells with an early peak of activation at 2 to 5 minutes PubMed
    Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
    env Pre-incubation of CD4+ T lymphocytes with anti-CD4 mAb or HIV-1 gp160 inhibits the activation of c-Jun N-terminal kinases (JNK) and extracellular signal-regulated protein kinase 2 (ERK2) in response to phorbol 12-myristate 13-acetate and ionomycin PubMed
    Nef nef HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 PubMed
    nef HIV-1 Nef inhibits ASK1-induced phosphorylation of p54/p46 JNK in cells. Nef mutant (152DEVGEANN/AAAAAAAA159) abolishes its inhibitory activity PubMed
    nef HIV-1 Nef activates c-jun nuclear kinase (JNK) in human glial cells and the resulting activation promotes cell proliferation PubMed
    nef The interaction between HIV-1 Nef and Vav leads to the activation of c-Jun N-terminal kinase (JNK) PubMed
    nef Using genetic and immunohistochemical studies in Drosophila transgenic lines, wild-type HIV-1 Nef demonstrates induction of JNK activation and apoptotic activities PubMed
    Tat tat HIV-1 Tat induces phosphorylation of MAPK8 (JNK) in CRT-MG human astroglioma cells PubMed
    tat HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes PubMed
    tat Pretreatment of microglia with HIV-1 Tat followed by treatment with CX3CL1 results in inhibition of CX3CL1-mediated activation of ERK1/2 and JNK MAPKs compared to cells not treated with Tat PubMed
    tat HIV-1 Tat-induced MAPK (ERK, JNK, and p38) activation is required for MMP-9 expression in human astrocytes PubMed
    tat Treatment with HIV-1 Tat induces phosphorylation of ERK1/2 and JNK in brain micro vascular endothelial cells (BMEC) and astrocytes, which mediates Tat-induced multidrug resistance-associated protein 1 (MRP1) expression PubMed
    tat Exposure of human umbilical vein endothelial cells to HIV-1 Tat causes broad activation of the unfolded-protein response in ER with phosphorylation of PERK, eIF2alpha, and JNK and induction of Grp78/BiP PubMed
    tat HIV-1 Tat activates c-jun (Activator Protein-1; AP-1) through the activation of JNK, an effect mediated through the activation of p56lck PubMed
    tat Extracellular HIV-1 Tat upregulates the expression of human beta-defensin 2 (hBD-2) via JNK/NF-KappaB/AP-1-dependent pathways in human B cells PubMed
    tat Knocking down Nox2 by siRNA decreases HIV-1 Tat-induced NF-KappaB activation as well as activation of MAP kinases including ERK, JNK, and p38 PubMed
    tat HIV-1 Tat and morphine-induced apoptosis in human neuroblastoma cells involves ERK1/2 and JNK activation PubMed
    tat Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat PubMed
    tat HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1) PubMed
    tat Sulfated polymannuroguluronate (SPMG) blocks the Tat-induced extracellular-signal regulated kinase 1/2- and c-jun amino-terminal kinase-mediated signalling pathways PubMed
    tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
    tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
    tat Activation of JNK by HIV-1 Tat is mediated by TRAF4 PubMed
    Vpr vpr HIV-1 Vpr-mediated regulation of IL6 involves MAPK8 (JnK-MAPK8) in astrocytes PubMed
    vpr Vpr-mediated CXCL8 (IL8) secretion from astrocytes involves MAPK8 (Jnk-MAPK) PubMed
    vpr Vpr-mediated CXCL8 (IL8) mRNA expression involves MAPK8 (Jnk-MAPK) in astrocytes PubMed
    vpr Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages. PubMed
    integrase gag-pol Cellular JNK1 phosphorylates HIV-1 IN on Ser57, leading to efficient HIV-1 infection and integration in primary human T lymphocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables JUN kinase activity TAS
    Traceable Author Statement
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within JUN phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in JUN phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular senescence TAS
    Traceable Author Statement
    more info
     
    involved_in energy homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of cell killing TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of establishment of protein localization to mitochondrion TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of macroautophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in basal dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase 8
    Names
    JUN N-terminal kinase
    MAP kinase 8
    c-Jun N-terminal kinase 1
    stress-activated protein kinase 1
    stress-activated protein kinase 1c
    NP_001265476.1
    NP_001265477.1
    NP_001310231.1
    NP_001310249.1
    NP_001310250.1
    NP_001310251.1
    NP_001310252.1
    NP_001310253.1
    NP_001310254.1
    NP_001310255.1
    NP_001310256.1
    NP_001310257.1
    NP_001310258.1
    NP_001310259.1
    NP_001310260.1
    NP_620634.1
    NP_620637.1
    XP_024303847.1
    XP_024303848.1
    XP_047281436.1
    XP_047281437.1
    XP_047281438.1
    XP_047281440.1
    XP_054222274.1
    XP_054222275.1
    XP_054222276.1
    XP_054222277.1
    XP_054222278.1
    XP_054222279.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029053.2 RefSeqGene

      Range
      5039..137722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001278547.2NP_001265476.1  mitogen-activated protein kinase 8 isoform beta2

      See identical proteins and their annotated locations for NP_001265476.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (JNK1-b2) encodes the longer of the two JNK1 beta isoforms (JNK1 beta2). The JNK1-b2 variant differs from the JNK1-a2 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 beta2 isoform is the same length as JNK1 alpha2 isoform, with a few aa difference in an internal protein segment. Variants JNK1-b2, 8, 9, and 16 all encode isoform beta2.
      Source sequence(s)
      AA808177, AC016397, AK292523, DA159335
      Consensus CDS
      CCDS7223.1
      UniProtKB/TrEMBL
      A0A286YES9, A1L4K2
      Related
      ENSP00000378974.4, ENST00000395611.7
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. NM_001278548.2NP_001265477.1  mitogen-activated protein kinase 8 isoform 5

      See identical proteins and their annotated locations for NP_001265477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame segment and uses a different acceptor splice site in the last coding exon compared to transcript variant JNK1-b2, resulting in a frameshift and a shorter isoform (5) with a different C-terminus compared to isoform JNK1 beta2.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS60527.1
      UniProtKB/TrEMBL
      B5BUB8
      Related
      ENSP00000353483.4, ENST00000360332.7
      Conserved Domains (1) summary
      cl21453
      Location:25284
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001323302.2NP_001310231.1  mitogen-activated protein kinase 8 isoform alpha1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (JNK1-a1) uses a different acceptor splice site in the last coding exon compared to transcript variant JNK1-a2, resulting in a frameshift and a shorter isoform (JNK1 alpha1) with a different C-terminus, compared to isoform JNK1 alpha2. The JNK1-a1 variant differs from the JNK1-b1 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 alpha1 isoform is the same length as JNK1 beta1 isoform, with a few aa difference in an internal protein segment. Variants JNK1-a1, 10, 12, and 13 all encode isoform alpha1.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7225.1
      UniProtKB/TrEMBL
      B5BUB8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    4. NM_001323320.2NP_001310249.1  mitogen-activated protein kinase 8 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC074325
      UniProtKB/TrEMBL
      A0A286YES9
    5. NM_001323321.2NP_001310250.1  mitogen-activated protein kinase 8 isoform beta1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), along with variants JNK1-b1 and 11, encodes isoform beta1.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7226.1
      UniProtKB/TrEMBL
      B5BUB8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    6. NM_001323322.2NP_001310251.1  mitogen-activated protein kinase 8 isoform beta2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), along with variants JNK1-b2, 9, and 16, encodes isoform beta2.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7223.1
      UniProtKB/TrEMBL
      A0A286YES9, A1L4K2
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    7. NM_001323323.2NP_001310252.1  mitogen-activated protein kinase 8 isoform beta2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), along with variants JNK1-b2, 8, and 16, encodes isoform beta2.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7223.1
      UniProtKB/TrEMBL
      A0A286YES9, A1L4K2
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    8. NM_001323324.2NP_001310253.1  mitogen-activated protein kinase 8 isoform alpha1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), along with variants JNK1-a1, 12, and 13, encodes isoform alpha1.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7225.1
      UniProtKB/TrEMBL
      B5BUB8
      Related
      ENSP00000363297.3, ENST00000374182.7
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    9. NM_001323325.2NP_001310254.1  mitogen-activated protein kinase 8 isoform beta1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), along with variants JNK1-b1 and 7, encodes isoform beta1.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7226.1
      UniProtKB/TrEMBL
      B5BUB8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    10. NM_001323326.2NP_001310255.1  mitogen-activated protein kinase 8 isoform alpha1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), along with variants JNK1-a1, 10, and 13, encodes isoform alpha1.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7225.1
      UniProtKB/TrEMBL
      B5BUB8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    11. NM_001323327.2NP_001310256.1  mitogen-activated protein kinase 8 isoform alpha1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), along with variants JNK1-a1, 10, and 12, encodes isoform alpha1.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7225.1
      UniProtKB/TrEMBL
      B5BUB8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    12. NM_001323328.2NP_001310257.1  mitogen-activated protein kinase 8 isoform alpha2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), along with variants JNK1-a2, 15, and 17, encodes isoform alpha2.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7224.1
      UniProtKB/Swiss-Prot
      B5BTZ5, B7ZLV4, D3DX88, D3DX92, P45983, Q15709, Q15712, Q15713, Q308M2
      UniProtKB/TrEMBL
      A0A286YEN5
      Conserved Domains (2) summary
      smart00220
      Location:26321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    13. NM_001323329.2NP_001310258.1  mitogen-activated protein kinase 8 isoform alpha2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), along with variants JNK1-a2, 14, and 17, encodes isoform alpha2.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7224.1
      UniProtKB/Swiss-Prot
      B5BTZ5, B7ZLV4, D3DX88, D3DX92, P45983, Q15709, Q15712, Q15713, Q308M2
      UniProtKB/TrEMBL
      A0A286YEN5
      Related
      ENSP00000363304.1, ENST00000374189.6
      Conserved Domains (2) summary
      smart00220
      Location:26321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    14. NM_001323330.2NP_001310259.1  mitogen-activated protein kinase 8 isoform beta2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), along with variants JNK1-b2, 8, and 9, encodes isoform beta2.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7223.1
      UniProtKB/TrEMBL
      A0A286YES9, A1L4K2
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    15. NM_001323331.2NP_001310260.1  mitogen-activated protein kinase 8 isoform alpha2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), along with variants JNK1-a2, 14, and 15, encodes isoform alpha2.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7224.1
      UniProtKB/Swiss-Prot
      B5BTZ5, B7ZLV4, D3DX88, D3DX92, P45983, Q15709, Q15712, Q15713, Q308M2
      UniProtKB/TrEMBL
      A0A286YEN5
      Conserved Domains (2) summary
      smart00220
      Location:26321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    16. NM_139046.4NP_620634.1  mitogen-activated protein kinase 8 isoform beta1

      See identical proteins and their annotated locations for NP_620634.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (JNK1-b1) uses a different acceptor splice site in the last coding exon compared to transcript variant JNK1-b2, resulting in a frameshift and a shorter isoform (JNK1 beta1) with a different C-terminus, compared to isoform JNK1 beta2. The JNK1-b1 variant differs from the JNK1-a1 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 beta1 isoform is the same length as JNK1 alpha1 isoform, with a few aa difference in an internal protein segment. Variants JNK1-b1, 7, and 11 all encode isoform beta1.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7226.1
      UniProtKB/TrEMBL
      B5BUB8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    17. NM_139049.4NP_620637.1  mitogen-activated protein kinase 8 isoform alpha2

      See identical proteins and their annotated locations for NP_620637.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (JNK1-a2) encodes the longer of the two JNK1 alpha isoforms (JNK1 alpha2). The JNK1-a2 variant differs from the JNK1-b2 variant in the use of an alternate internal coding exon of the same length. Thus, JNK1 alpha2 isoform is the same length as JNK1 beta2 isoform, with a few aa difference in an internal protein segment. Variants JNK1-a2, 14, 15 and 17 all encode isoform alpha2.
      Source sequence(s)
      AC016397, AC074325
      Consensus CDS
      CCDS7224.1
      UniProtKB/Swiss-Prot
      B5BTZ5, B7ZLV4, D3DX88, D3DX92, P45983, Q15709, Q15712, Q15713, Q308M2
      UniProtKB/TrEMBL
      A0A286YEN5
      Conserved Domains (2) summary
      smart00220
      Location:26321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RNA

    1. NR_136583.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC074325
    2. NR_136584.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC074325
    3. NR_136585.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016397, AC074325

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      48306677..48439360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425482.1XP_047281438.1  mitogen-activated protein kinase 8 isoform X2

      UniProtKB/TrEMBL
      B5BUB8
      Related
      ENSP00000363294.3, ENST00000374179.8
    2. XM_047425480.1XP_047281436.1  mitogen-activated protein kinase 8 isoform X1

      UniProtKB/TrEMBL
      A0A286YES9, A1L4K2
    3. XM_047425484.1XP_047281440.1  mitogen-activated protein kinase 8 isoform X2

      UniProtKB/TrEMBL
      B5BUB8
    4. XM_024448079.2XP_024303847.1  mitogen-activated protein kinase 8 isoform X1

      UniProtKB/TrEMBL
      A0A286YES9, A1L4K2
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    5. XM_024448080.2XP_024303848.1  mitogen-activated protein kinase 8 isoform X2

      UniProtKB/TrEMBL
      B5BUB8
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    6. XM_047425481.1XP_047281437.1  mitogen-activated protein kinase 8 isoform X1

      UniProtKB/TrEMBL
      A0A286YES9, A1L4K2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      49155699..49288442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366303.1XP_054222278.1  mitogen-activated protein kinase 8 isoform X2

      UniProtKB/TrEMBL
      B5BUB8
    2. XM_054366299.1XP_054222274.1  mitogen-activated protein kinase 8 isoform X1

      UniProtKB/TrEMBL
      A0A286YES9, A1L4K2
    3. XM_054366304.1XP_054222279.1  mitogen-activated protein kinase 8 isoform X2

      UniProtKB/TrEMBL
      B5BUB8
    4. XM_054366300.1XP_054222275.1  mitogen-activated protein kinase 8 isoform X1

      UniProtKB/TrEMBL
      A0A286YES9, A1L4K2
    5. XM_054366302.1XP_054222277.1  mitogen-activated protein kinase 8 isoform X2

      UniProtKB/TrEMBL
      B5BUB8
    6. XM_054366301.1XP_054222276.1  mitogen-activated protein kinase 8 isoform X1

      UniProtKB/TrEMBL
      A0A286YES9, A1L4K2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_002750.3: Suppressed sequence

      Description
      NM_002750.3: This RefSeq was removed because the 5' UTR was partial.