Lrrc8a leucine rich repeat containing 8 VRAC subunit A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrc8aprovided by RGD
Official Full Name: leucine rich repeat containing 8 VRAC subunit Aprovided by RGD
Primary source: RGD:1311690
See related: EnsemblRapid:ENSRNOG00000025296 AllianceGenome:RGD:1311690
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lrrc8
Summary: Enables volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; response to osmotic stress; and taurine transmembrane transport. Predicted to be located in cell surface and lysosomal membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 164.1), Heart (RPKM 148.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (33902299..33934989)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13509577..13537174)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8801544..8829506)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRRC8A is essential for volume-regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension.
Title: LRRC8A is essential for volume-regulated anion channel in smooth muscle cells contributing to cerebrovascular remodeling during hypertension.
LRRC8A plays an essential role in the progression of AFC in LPS-induced acute lung injury
Title: Novel insights into the role of LRRC8A in ameliorating alveolar fluid clearance in LPS induced acute lung injury.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclic-GMP-AMP transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cyclic-GMP-AMP transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info
enables volume-sensitive anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables volume-sensitive anion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables volume-sensitive anion channel activity	ISO Inferred from Sequence Orthology more info
enables volume-sensitive anion channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biological_process	ND No biological Data available more info
involved_in cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic anion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic anion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic anion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in pre-B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in pre-B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein hexamerization	ISO Inferred from Sequence Orthology more info
involved_in protein hexamerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in taurine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of monoatomic ion channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of monoatomic ion channel complex	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: volume-regulated anion channel subunit LRRC8A

Names: leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8A; leucine-rich repeat-containing 8; leucine-rich repeat-containing protein 8A; swelling protein 1 SWELL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024782.1 → NP_001019953.1 volume-regulated anion channel subunit LRRC8A

See identical proteins and their annotated locations for NP_001019953.1

Status: PROVISIONAL

Source sequence(s)

BC097371

UniProtKB/Swiss-Prot

Q4V8I7

UniProtKB/TrEMBL

A0A8L2R553, A6JTW3

Related

ENSRNOP00000031726.4, ENSRNOT00000033934.7

Conserved Domains (3) summary

COG4886
Location:510 → 767

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:546 → 568

LRR_RI; leucine-rich repeat [structural motif]

pfam12534
Location:1 → 340

Pannexin_like; Pannexin-like TM region of LRRC8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

33902299..33934989

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105233.2 → XP_038961161.1 volume-regulated anion channel subunit LRRC8A isoform X1

UniProtKB/Swiss-Prot

Q4V8I7

UniProtKB/TrEMBL

A0A8L2R553, A6JTW3

Conserved Domains (3) summary

COG4886
Location:510 → 767

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:546 → 568

LRR_RI; leucine-rich repeat [structural motif]

pfam12534
Location:1 → 340

Pannexin_like; Pannexin-like TM region of LRRC8
XM_063283945.1 → XP_063140015.1 volume-regulated anion channel subunit LRRC8A isoform X1

UniProtKB/Swiss-Prot

Q4V8I7

UniProtKB/TrEMBL

A0A8L2R553, A6JTW3
XM_017591840.3 → XP_017447329.1 volume-regulated anion channel subunit LRRC8A isoform X1

UniProtKB/Swiss-Prot

Q4V8I7

UniProtKB/TrEMBL

A0A8L2R553, A6JTW3

Conserved Domains (3) summary

COG4886
Location:510 → 767

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:546 → 568

LRR_RI; leucine-rich repeat [structural motif]

pfam12534
Location:1 → 340

Pannexin_like; Pannexin-like TM region of LRRC8
XM_063283944.1 → XP_063140014.1 volume-regulated anion channel subunit LRRC8A isoform X1

UniProtKB/Swiss-Prot

Q4V8I7

UniProtKB/TrEMBL

A0A8L2R553, A6JTW3
XM_017591841.3 → XP_017447330.1 volume-regulated anion channel subunit LRRC8A isoform X1

UniProtKB/Swiss-Prot

Q4V8I7

UniProtKB/TrEMBL

A0A8L2R553, A6JTW3

Conserved Domains (3) summary

COG4886
Location:510 → 767

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:546 → 568

LRR_RI; leucine-rich repeat [structural motif]

pfam12534
Location:1 → 340

Pannexin_like; Pannexin-like TM region of LRRC8
XM_063283942.1 → XP_063140012.1 volume-regulated anion channel subunit LRRC8A isoform X1

UniProtKB/Swiss-Prot

Q4V8I7

UniProtKB/TrEMBL

A0A8L2R553, A6JTW3
XM_039105234.2 → XP_038961162.1 volume-regulated anion channel subunit LRRC8A isoform X1

UniProtKB/Swiss-Prot

Q4V8I7

UniProtKB/TrEMBL

A0A8L2R553, A6JTW3

Conserved Domains (3) summary

COG4886
Location:510 → 767

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:546 → 568

LRR_RI; leucine-rich repeat [structural motif]

pfam12534
Location:1 → 340

Pannexin_like; Pannexin-like TM region of LRRC8
XM_063283946.1 → XP_063140016.1 volume-regulated anion channel subunit LRRC8A isoform X1

UniProtKB/Swiss-Prot

Q4V8I7

UniProtKB/TrEMBL

A0A8L2R553, A6JTW3
XM_017591842.3 → XP_017447331.1 volume-regulated anion channel subunit LRRC8A isoform X1

UniProtKB/Swiss-Prot

Q4V8I7

UniProtKB/TrEMBL

A0A8L2R553, A6JTW3

Conserved Domains (3) summary

COG4886
Location:510 → 767

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:546 → 568

LRR_RI; leucine-rich repeat [structural motif]

pfam12534
Location:1 → 340

Pannexin_like; Pannexin-like TM region of LRRC8