U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    INA internexin neuronal intermediate filament protein alpha [ Homo sapiens (human) ]

    Gene ID: 9118, updated on 10-Dec-2024

    Summary

    Official Symbol
    INAprovided by HGNC
    Official Full Name
    internexin neuronal intermediate filament protein alphaprovided by HGNC
    Primary source
    HGNC:HGNC:6057
    See related
    Ensembl:ENSG00000148798 MIM:605338; AllianceGenome:HGNC:6057
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEF5; NF66; NF-66; TXBP-1
    Summary
    Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]
    Expression
    Biased expression in brain (RPKM 37.1) and adrenal (RPKM 7.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See INA in Genome Data Viewer
    Location:
    10q24.33
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (103277138..103290346)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (104165761..104178983)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (105036895..105050103)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ST13, Hsp70 interacting protein pseudogene 13 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:104990595-104991592 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:104991593-104992590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:105014513-105015012 Neighboring gene ribulose-5-phosphate-3-epimerase like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105037310-105037914 Neighboring gene polycomb group ring finger 6 Neighboring gene RNA, U11 small nuclear 3, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:105110125-105110630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2778 Neighboring gene NANOG hESC enhancer GRCh37_chr10:105114252-105114806 Neighboring gene Sharpr-MPRA regulatory region 5935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3957 Neighboring gene TATA-box binding protein associated factor 5 Neighboring gene ATP synthase membrane subunit k

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (8 hits/1251 screens)

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog
    Genome-wide association analysis identifies susceptibility loci for migraine without aura.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify internexin neuronal intermediate filament protein alpha unit (INA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify internexin neuronal intermediate filament protein alpha unit (INA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify internexin neuronal intermediate filament protein alpha unit (INA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify internexin neuronal intermediate filament protein alpha unit (INA), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • FLJ18662, FLJ57501, MGC12702

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse  
    is_active_in cytoplasm  
    located_in cytoplasmic ribonucleoprotein granule PubMed 
    located_in extracellular space PubMed 
    is_active_in intermediate filament  
    located_in neurofilament  
    is_active_in postsynaptic intermediate filament cytoskeleton  

    General protein information

    Preferred Names
    alpha-internexin
    Names
    66 kDa neurofilament protein
    alpha-Inx
    neurofilament 5 (66kD)
    neurofilament-66, tax-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012318.1 RefSeqGene

      Range
      4976..18184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_032727.4 → NP_116116.1  alpha-internexin

      See identical proteins and their annotated locations for NP_116116.1

      Status: REVIEWED

      Source sequence(s)
      AL591408, BC006359
      Consensus CDS
      CCDS7545.1
      UniProtKB/Swiss-Prot
      B1AQK0, Q16352, Q9BRC5
      Related
      ENSP00000358865.4, ENST00000369849.9
      Conserved Domains (2) summary
      pfam00038
      Location:93 → 406
      Filament; Intermediate filament protein
      pfam04732
      Location:10 → 92
      Filament_head; Intermediate filament head (DNA binding) region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      103277138..103290346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      104165761..104178983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.