U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Brf Brf RNA polymerase III subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42087, updated on 27-Dec-2024

    Summary

    Official Symbol
    Brfprovided by FlyBase
    Official Full Name
    Brf RNA polymerase III subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038499
    Locus tag
    Dmel_CG31256
    See related
    AllianceGenome:FB:FBgn0038499
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    brf; BRF; Brf1; BRF1; CG31256; CG4155; CG5419; Dmel\CG31256; TFIIIB
    Summary
    Enables RNA polymerase III type 3 promoter sequence-specific DNA binding activity and TBP-class protein binding activity. Contributes to core promoter sequence-specific DNA binding activity. Involved in transcription by RNA polymerase III. Part of transcription factor TFIIIB complex. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and larval nervous system. Human ortholog(s) of this gene implicated in cerebellofaciodental syndrome. Orthologous to human BRF1 (BRF1 general transcription factor IIIB subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Brf in Genome Data Viewer
    Location:
    90A3-90A5; 3-60 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17374833..17391337, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13200555..13217059, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beaten path IIa Neighboring gene long non-coding RNA:CR44256 Neighboring gene long non-coding RNA:CR43196 Neighboring gene lute Neighboring gene antisense RNA:CR44160 Neighboring gene sds22 Neighboring gene Cellular Repressor of E1A-stimulated Genes

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in nucleus  
    part_of transcription factor TFIIIB complex  
    part_of transcription factor TFIIIB complex PubMed 
    part_of transcription preinitiation complex  
    part_of transcription regulator complex PubMed 

    General protein information

    Preferred Names
    Brf RNA polymerase III subunit
    Names
    Brf-PA
    Brf-PB
    CG31256-PA
    CG31256-PB
    RNA Pol III transcription factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17374833..17391337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142359.3 → NP_650616.2  Brf RNA polymerase III subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650616.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960W2, Q9NG52, Q9VEL2
      Related
      FBpp0082893
      Conserved Domains (5) summary
      COG1405
      Location:6 → 270
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      cd00043
      Location:183 → 268
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam07741
      Location:441 → 531
      BRF1; Brf1-like TBP-binding domain
      pfam08271
      Location:5 → 44
      TF_Zn_Ribbon; TFIIB zinc-binding
      cl00050
      Location:108 → 164
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    2. NM_001170165.2 → NP_001163636.1  Brf RNA polymerase III subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163636.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960W2, Q9NG52, Q9VEL2
      Conserved Domains (5) summary
      COG1405
      Location:6 → 270
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      cd00043
      Location:183 → 268
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam07741
      Location:441 → 531
      BRF1; Brf1-like TBP-binding domain
      pfam08271
      Location:5 → 44
      TF_Zn_Ribbon; TFIIB zinc-binding
      cl00050
      Location:108 → 164
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    External link. Please review our privacy policy.