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    SIN3 transcriptional regulator SIN3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854158, updated on 27-Dec-2024

    Summary

    Official Symbol
    SIN3
    Official Full Name
    transcriptional regulator SIN3
    Primary source
    SGD:S000005364
    Locus tag
    YOL004W
    See related
    AllianceGenome:SGD:S000005364; FungiDB:YOL004W; VEuPathDB:YOL004W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CPE1; GAM2; RPD1; SDI1; SDS16; UME4
    Summary
    Enables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including G2/M transition of mitotic cell cycle; rDNA chromatin condensation; and regulation of macromolecule metabolic process. Part of Rpd3L complex and Rpd3S complex. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A) and SIN3B (SIN3 transcription regulator family member B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See SIN3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (316938..321548)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase 1 Neighboring gene DNA-directed RNA polymerase II core subunit RPB11 Neighboring gene palmitoyltransferase PFA4 Neighboring gene PAQR-type receptor

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle PubMed 
    involved_in cell division  
    involved_in cellular response to heat PubMed 
    involved_in chromatin organization  
    involved_in double-strand break repair via nonhomologous end joining PubMed 
    involved_in meiotic cell cycle PubMed 
    involved_in negative regulation of rDNA heterochromatin formation PubMed 
    involved_in negative regulation of silent mating-type cassette heterochromatin formation PubMed 
    involved_in negative regulation of transcription by RNA polymerase I PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in nucleophagy PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in rDNA chromatin condensation PubMed 
    involved_in regulation of DNA-templated DNA replication initiation PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L complex PubMed 
    part_of Rpd3L complex PubMed 
    part_of Rpd3L-Expanded complex PubMed 
    part_of Rpd3S complex PubMed 
    part_of Sin3-type complex  
    part_of Sin3-type complex PubMed 
    located_in chromatin  
    located_in nucleus  

    General protein information

    Preferred Names
    transcriptional regulator SIN3
    NP_014639.1
    • Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      316938..321548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183258.1 → NP_014639.1  TPA: transcriptional regulator SIN3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W263, P22579, Q08049
      UniProtKB/TrEMBL
      A6ZNK2, C7GJV6
      Conserved Domains (4) summary
      COG5602
      Location:75 → 1493
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:240 → 284
      PAH; Paired amphipathic helix repeat
      pfam08295
      Location:749 → 844
      Sin3_corepress; Sin3 family co-repressor
      pfam16879
      Location:1138 → 1410
      Sin3a_C; C-terminal domain of Sin3a protein
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