SIR1 Sir1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: SIR1
Official Full Name: Sir1p
Primary source: SGD:S000001809
Locus tag: YKR101W
See related: AllianceGenome:SGD:S000001809; FungiDB:YKR101W; VEuPathDB:YKR101W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in silent mating-type cassette heterochromatin formation. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See SIR1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (640540..642504)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

silencing requires Sir2, a highly-conserved NAD(+)-dependent histone deacetylase. At locations other than the rDNA, silencing also requires additional Sir proteins, Sir1, Sir3, and Sir4 that together form a repressive heterochromatin-like structure termed silent chromatin.
Title: The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.
data provide the most complete picture to date of how the earliest SIR1-containing SIR silencing complex functioned and the evolutionary trajectories it may have followed
Title: Evolution and Functional Trajectory of Sir1 in Gene Silencing.
The functional specialization of Sir3,as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions.
Title: Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.
The functional duality might contribute to Sir1's selectivity for silencer-bound origin recognition complex in vivo.
Title: Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1.
The role for Ku in silencing both HMR and HML was masked by SIR1.
Title: The Ku complex in silencing the cryptic mating-type loci of Saccharomyces cerevisiae.
Epistatic interaction between the K-homology domain protein HEK2 and SIR1 at HMR and telomeres in yeast.
Title: Epistatic interaction between the K-homology domain protein HEK2 and SIR1 at HMR and telomeres in yeast.
SIR1 plays role in the origin recognition complex dependent silencing for origin firing at silent mating type loci
Title: Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin silencing complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Sir1p

NP_013027.4

Protein involved in silencing at mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin