EIF3K eukaryotic translation initiation factor 3 subunit K [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF3Kprovided by HGNC
Official Full Name: eukaryotic translation initiation factor 3 subunit Kprovided by HGNC
Primary source: HGNC:HGNC:24656
See related: Ensembl:ENSG00000178982 MIM:609596; AllianceGenome:HGNC:24656
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: M9; ARG134; PLAC24; PTD001; EIF3S12; HSPC029; MSTP001; PLAC-24; PRO1474; EIF3-p28
Summary: The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in heart (RPKM 136.4), duodenum (RPKM 100.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (38619188..38636954)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (41423166..41440932)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39109828..39127594)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Whereas the eIF3c knockdown reduces it, downregulation of eIF3k or eIF3l increases mRNA recruitment, suggesting that the latter subunits possess a regulatory potential. Altogether this study provides new insights into the role of human eIF3 in the initial assembly steps of the translational machinery
Title: Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.
eIF3K subunit interacts directly with the PML protein.
Title: The translation initiation factor 3 subunit eIF3K interacts with PML and associates with PML nuclear bodies.
eIF3k, originally identified as the smallest subunit of eukaryotic translation initiation factor 3 (eIF3) complexes, also localizes to keratin intermediate filaments and physically associates with K18 in epithelial cells.
Title: eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions.
eIF3k has three putative protein-binding surfaces and has potential RNA binding activity
Title: Crystal structure of human eIF3k, the first structure of eIF3 subunits.
cyclin D3 specifically interacted with eIF3k through its C-terminal domain; eIF3k distributed both in nucleus and cytoplasm and colocalized with cyclin D3
Title: Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3.
identification of a novel 24-kDa protein that binds directly to dynein intermediate chain [PLAC-24]
Title: PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pol	gag-pol	HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit K (EIF3K) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit K (EIF3K) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5S2421 (e-PCR)
- UniSTS:33292

RH91438 (e-PCR)
- UniSTS:85530

A008T17 (e-PCR)
- UniSTS:53925

RH45462 (e-PCR)
- UniSTS:55471

MARC_7311-7312:996687763:1 (e-PCR)
- UniSTS:269766

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to translation initiation factor activity	IC Inferred by Curator more info	PubMed
contributes_to translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in formation of cytoplasmic translation initiation complex	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IC Inferred by Curator more info	PubMed
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit K

Names: eIF-3 p28; eukaryotic translation initiation factor 3, subunit 12; muscle specific; muscle-specific gene M9 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001300992.2 → NP_001287921.1 eukaryotic translation initiation factor 3 subunit K isoform 2

See identical proteins and their annotated locations for NP_001287921.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

BG470776, BG943109, JX870647

Consensus CDS

CCDS74360.1

UniProtKB/TrEMBL

B4DVD7, K7ERF1

Related

ENSP00000468231.1, ENST00000592558.1

Conserved Domains (1) summary

cl24019
Location:61 → 163

CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
NM_001308393.2 → NP_001295322.1 eukaryotic translation initiation factor 3 subunit K isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus than isoform 1.

Source sequence(s)

AI054400, BG488547, BG943109

Consensus CDS

CCDS77293.1

UniProtKB/TrEMBL

B4DQ48, K7EK53

Related

ENSP00000465460.1, ENST00000593149.5

Conserved Domains (1) summary

cl24019
Location:1 → 102

CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
NM_013234.4 → NP_037366.1 eukaryotic translation initiation factor 3 subunit K isoform 1

See identical proteins and their annotated locations for NP_037366.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC001031, BG943109

Consensus CDS

CCDS12517.1

UniProtKB/Swiss-Prot

A8K0I9, B7ZAM9, Q96IQ0, Q9UBQ5, Q9Y6D1

UniProtKB/TrEMBL

B4DVD7

Related

ENSP00000248342.3, ENST00000248342.9

Conserved Domains (1) summary

pfam10075
Location:61 → 189

CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family