PUM2 pumilio RNA binding family member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PUM2provided by HGNC
Official Full Name: pumilio RNA binding family member 2provided by HGNC
Primary source: HGNC:HGNC:14958
See related: Ensembl:ENSG00000055917 MIM:607205; AllianceGenome:HGNC:14958
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PUMH2; PUML2
Summary: This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression: Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p24.1

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (20248691..20352253, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (20282228..20385776, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (20448452..20552014, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p.
Title: RNA-binding protein PUM2 promotes T-cell acute lymphoblastic leukemia via competitively binding to RBM5 3'UTR with miR-28-5p.
Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.
Title: Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.
Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.
Title: Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.
CAFs-Derived Exosomal miRNA-130a Confers Cisplatin Resistance of NSCLC Cells Through PUM2-Dependent Packaging.
Title: CAFs-Derived Exosomal miRNA-130a Confers Cisplatin Resistance of NSCLC Cells Through PUM2-Dependent Packaging.
RNA-binding protein PUM2 regulates mesenchymal stem cell fate via repression of JAK2 and RUNX2 mRNAs.
Title: RNA-binding protein PUM2 regulates mesenchymal stem cell fate via repression of JAK2 and RUNX2 mRNAs.
Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.
Title: Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.
LncRNA TUG1 aggravates the progression of cervical cancer by binding PUM2.
Title: LncRNA TUG1 aggravates the progression of cervical cancer by binding PUM2.
The results suggest that PUM1-2 affects the expression of pluripotency genes as well as the efficiency of the cardiac differentiation process.
Title: Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.
circ_0075932 directly bound with the RNA-binding protein PUM2, which was reported to positively regulated AuroraA kinase, thus activating the NF-kappaB pathway. Moreover, either silencing PUM2, silencing AuroraA, or blockade of NF-kappaB activation, could abrogate the promoting effect of adipocyte-derived exosomal circ_0075932 on cell inflammation and apoptosis.
Title: Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-κB pathway.
A transcriptome-wide approach was used to determine the binding profiles and inter-dependencies of Argonaute2 (AGO2), Pumilio (PUM1 and PUM2) sites on mRNA 3' untranslated regions (3'UTRs).
Title: Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with pumilio homolog 2 (PUM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH79823 (e-PCR)
- UniSTS:91657

38994323 (e-PCR)
- UniSTS:497681

SHGC-106834 (e-PCR)
- UniSTS:170016

G09500 (e-PCR)
- UniSTS:1825

Pum2 (e-PCR), detects polymorphism
- UniSTS:479021

G16351 (e-PCR)
- UniSTS:29764

RH12096 (e-PCR)
- UniSTS:3421

EST24F7 (e-PCR)
- UniSTS:263267

RH12262 (e-PCR)
- UniSTS:19045

SHGC-31204 (e-PCR)
- UniSTS:1411

G19793 (e-PCR)
- UniSTS:44933

A001Y33 (e-PCR)
- UniSTS:44934

SHGC-58462 (e-PCR)
- UniSTS:94348

RH122597 (e-PCR)
- UniSTS:138660

RH25440 (e-PCR)
- UniSTS:78056

Clone Names

FLJ36528, KIAA0235, MGC138251, MGC138253

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables lncRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	TAS Traceable Author Statement more info	PubMed
enables miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables pumilio-response element binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	TAS Traceable Author Statement more info	PubMed
involved_in adipose tissue development	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in hair follicle development	IEA Inferred from Electronic Annotation more info
involved_in miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RIG-I signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sprouting of injured axon	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-transcriptional regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chromosome segregation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of intracellular mRNA localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA stability	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of miRNA-mediated gene silencing	TAS Traceable Author Statement more info	PubMed
involved_in regulation of postsynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in skeletal system development	IEA Inferred from Electronic Annotation more info
involved_in stress granule assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pumilio homolog 2

Names: pumilio-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282752.3 → NP_001269681.1 pumilio homolog 2 isoform 2

Status: REVIEWED

Source sequence(s)

AC007041, AF315591, AK304198, BG717417

UniProtKB/TrEMBL

A0A0C4DG68

Conserved Domains (1) summary

cd07920
Location:665 → 986

Pumilio; Pumilio-family RNA binding domain
NM_001282790.2 → NP_001269719.1 pumilio homolog 2 isoform 3

Status: REVIEWED

Source sequence(s)

AC007041, AF315591, BC143550, BX094307

UniProtKB/TrEMBL

A0A0C4DG68, B7ZL34

Conserved Domains (1) summary

cd07920
Location:642 → 963

Pumilio; Pumilio-family RNA binding domain
NM_001282791.2 → NP_001269720.1 pumilio homolog 2 isoform 4

Status: REVIEWED

Source sequence(s)

AC007041, AF272350, AF315591, BC143552, BX094307

UniProtKB/TrEMBL

A0A0C4DG68

Related

ENSP00000409905.1, ENST00000440577.5

Conserved Domains (1) summary

cd07920
Location:586 → 907

Pumilio; Pumilio-family RNA binding domain
NM_001352917.3 → NP_001339846.1 pumilio homolog 2 isoform 5

Status: REVIEWED

Source sequence(s)

AC007041

Consensus CDS

CCDS92717.1

UniProtKB/Swiss-Prot

B3KSL0, B4E2B6, D6W527, O00234, Q53TV7, Q8TB72, Q8WY43, Q9HAN2

Related

ENSP00000516061.1, ENST00000704930.1

Conserved Domains (1) summary

cd07920
Location:721 → 1044

Pumilio; Pumilio-family RNA binding domain
NM_001352918.2 → NP_001339847.1 pumilio homolog 2 isoform 1

Status: REVIEWED

Source sequence(s)

AC007041

Consensus CDS

CCDS1698.1

UniProtKB/TrEMBL

A0A0C4DG68

Conserved Domains (1) summary

cd07920
Location:721 → 1042

Pumilio; Pumilio-family RNA binding domain
NM_001352919.3 → NP_001339848.1 pumilio homolog 2 isoform 1

Status: REVIEWED

Source sequence(s)

AC007041

Consensus CDS

CCDS1698.1

UniProtKB/TrEMBL

A0A0C4DG68

Related

ENSP00000338173.5, ENST00000338086.9

Conserved Domains (1) summary

cd07920
Location:721 → 1042

Pumilio; Pumilio-family RNA binding domain
NM_001352920.3 → NP_001339849.1 pumilio homolog 2 isoform 6

Status: REVIEWED

Source sequence(s)

AC007041

UniProtKB/TrEMBL

A0A0C4DG68

Conserved Domains (1) summary

cd07920
Location:642 → 965

Pumilio; Pumilio-family RNA binding domain
NM_001352923.3 → NP_001339852.1 pumilio homolog 2 isoform 6

Status: REVIEWED

Source sequence(s)

AC007041

UniProtKB/TrEMBL

A0A0C4DG68

Conserved Domains (1) summary

cd07920
Location:642 → 965

Pumilio; Pumilio-family RNA binding domain
NM_001352925.3 → NP_001339854.1 pumilio homolog 2 isoform 3

Status: REVIEWED

Source sequence(s)

AC007041

UniProtKB/TrEMBL

A0A0C4DG68, B7ZL34

Conserved Domains (1) summary

cd07920
Location:642 → 963

Pumilio; Pumilio-family RNA binding domain
NM_001352926.2 → NP_001339855.1 pumilio homolog 2 isoform 3

Status: REVIEWED

Source sequence(s)

AC007041

UniProtKB/TrEMBL

A0A0C4DG68, B7ZL34

Conserved Domains (1) summary

cd07920
Location:642 → 963

Pumilio; Pumilio-family RNA binding domain
NM_001352927.3 → NP_001339856.1 pumilio homolog 2 isoform 3

Status: REVIEWED

Source sequence(s)

AC007041

UniProtKB/TrEMBL

A0A0C4DG68, B7ZL34

Conserved Domains (1) summary

cd07920
Location:642 → 963

Pumilio; Pumilio-family RNA binding domain
NM_001352928.3 → NP_001339857.1 pumilio homolog 2 isoform 3

Status: REVIEWED

Source sequence(s)

AC007041

UniProtKB/TrEMBL

A0A0C4DG68, B7ZL34

Conserved Domains (1) summary

cd07920
Location:642 → 963

Pumilio; Pumilio-family RNA binding domain
NM_001352929.3 → NP_001339858.1 pumilio homolog 2 isoform 4

Status: REVIEWED

Source sequence(s)

AC007041

UniProtKB/TrEMBL

A0A0C4DG68

Conserved Domains (1) summary

cd07920
Location:586 → 907

Pumilio; Pumilio-family RNA binding domain
NM_001352930.3 → NP_001339859.1 pumilio homolog 2 isoform 7

Status: REVIEWED

Source sequence(s)

AC007041

UniProtKB/TrEMBL

A0A0C4DG68

Conserved Domains (1) summary

cd07920
Location:495 → 816

Pumilio; Pumilio-family RNA binding domain
NM_015317.5 → NP_056132.1 pumilio homolog 2 isoform 1

Status: REVIEWED

Source sequence(s)

AC007041, AF315591, AK093847, BG717417

Consensus CDS

CCDS1698.1

UniProtKB/TrEMBL

A0A0C4DG68

Related

ENSP00000354370.4, ENST00000361078.7

Conserved Domains (1) summary

cd07920
Location:721 → 1042

Pumilio; Pumilio-family RNA binding domain