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    cyh-1 Cyclin-H [ Caenorhabditis elegans ]

    Gene ID: 190078, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyh-1
    Official Full Name
    Cyclin-H
    Primary source
    WormBase:WBGene00021714
    Locus tag
    CELE_Y49F6B.1
    See related
    AllianceGenome:WB:WBGene00021714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyh-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (3505017..3510597)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Cuticle collagen 71 Neighboring gene ncRNA Neighboring gene Fcf2 pre-rRNA processing C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene TransThyretin-Related family domain Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair. Thijssen KL, et al. Commun Biol, 2021 Nov 25. PMID 34824371, Free PMC Article
    2. Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos. Cowan CR, et al. Nat Cell Biol, 2006 Dec. PMID 17115027
    3. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-H
    NP_001379352.1
    • Partially confirmed by transcript evidence
    NP_001379353.1
    • Partially confirmed by transcript evidence
    NP_001379354.1
    • Confirmed by transcript evidence
    NP_001379355.1
    • Partially confirmed by transcript evidence
    NP_001379356.1
    • Partially confirmed by transcript evidence
    NP_494564.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      3505017..3510597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062163.5 → NP_494564.2  Cyclin-H [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494564.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4U0
      Conserved Domains (2) summary
      cd00043
      Location:64 → 147
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      pfam16899
      Location:159 → 270
      Cyclin_C_2; Cyclin C-terminal domain

    2. NM_001393040.1 → NP_001379352.1  Cyclin-H [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9SUL6
      Conserved Domains (2) summary
      cd20524
      Location:3 → 157
      CYCLIN_CCNH_rpt1; first cyclin box found in cyclin-H (CCNH) and similar proteins
      cd20525
      Location:160 → 310
      CYCLIN_CCNH_rpt2; second cyclin box found in cyclin-H (CCNH) and similar proteins

    3. NM_001393041.1 → NP_001379355.1  Cyclin-H [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9SUM0
      Conserved Domains (2) summary
      cd20524
      Location:3 → 157
      CYCLIN_CCNH_rpt1; first cyclin box found in cyclin-H (CCNH) and similar proteins
      cd20525
      Location:160 → 308
      CYCLIN_CCNH_rpt2; second cyclin box found in cyclin-H (CCNH) and similar proteins

    4. NM_001393042.1 → NP_001379353.1  Cyclin-H [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9SUI7
      Conserved Domains (2) summary
      cd20524
      Location:3 → 156
      CYCLIN_CCNH_rpt1; first cyclin box found in cyclin-H (CCNH) and similar proteins
      cd20525
      Location:159 → 309
      CYCLIN_CCNH_rpt2; second cyclin box found in cyclin-H (CCNH) and similar proteins

    5. NM_001393043.1 → NP_001379356.1  Cyclin-H [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9XND1
      Conserved Domains (2) summary
      cd20524
      Location:3 → 156
      CYCLIN_CCNH_rpt1; first cyclin box found in cyclin-H (CCNH) and similar proteins
      cd20525
      Location:159 → 307
      CYCLIN_CCNH_rpt2; second cyclin box found in cyclin-H (CCNH) and similar proteins

    6. NM_001393044.1 → NP_001379354.1  Cyclin-H [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9SW78
      Conserved Domains (2) summary
      cd20524
      Location:3 → 154
      CYCLIN_CCNH_rpt1; first cyclin box found in cyclin-H (CCNH) and similar proteins
      cd20525
      Location:157 → 307
      CYCLIN_CCNH_rpt2; second cyclin box found in cyclin-H (CCNH) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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