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    RPN1 ribophorin I [ Homo sapiens (human) ]

    Gene ID: 6184, updated on 9-Dec-2024

    Summary

    Official Symbol
    RPN1provided by HGNC
    Official Full Name
    ribophorin Iprovided by HGNC
    Primary source
    HGNC:HGNC:10381
    See related
    Ensembl:ENSG00000163902 MIM:180470; AllianceGenome:HGNC:10381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OST1; RBPH1
    Summary
    This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 116.8), placenta (RPKM 79.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPN1 in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (128619969..128650818, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (131361936..131392788, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128338812..128369661, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1565 Neighboring gene uncharacterized LOC124909430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128309380-128309880 Neighboring gene Sharpr-MPRA regulatory region 3129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128321651-128322150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20484 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:128336746-128337257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128363771-128364272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:128364273-128364772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20489 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:128384140-128385070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20490 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:128399363-128400055 Neighboring gene POU class 5 homeobox 1 pseudogene 6 Neighboring gene small nucleolar RNA SNORA24

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic variation associated with circulating monocyte count in the eMERGE Network.
    EBI GWAS Catalog
    Multiple loci are associated with white blood cell phenotypes.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribophorin I (RPN1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of ribophorin I (RPN1) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686B16177

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of oligosaccharyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of oligosaccharyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of oligosaccharyltransferase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in rough endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
    Names
    RPN-I
    dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit
    oligosaccharyltransferase 1 homolog
    oligosaccharyltransferase complex subunit (non-catalytic)
    ribophorin-1
    NP_002941.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002950.4NP_002941.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor

      See identical proteins and their annotated locations for NP_002941.1

      Status: REVIEWED

      Source sequence(s)
      AC079945, BC010839
      Consensus CDS
      CCDS3051.1
      UniProtKB/Swiss-Prot
      B2R5Z0, D3DNB6, P04843, Q68DT1
      UniProtKB/TrEMBL
      Q53EP4
      Related
      ENSP00000296255.3, ENST00000296255.8
      Conserved Domains (1) summary
      pfam04597
      Location:32457
      Ribophorin_I; Ribophorin I

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      128619969..128650818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      131361936..131392788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)