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    RPL9 ribosomal protein L9 [ Homo sapiens (human) ]

    Gene ID: 6133, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RPL9provided by HGNC
    Official Full Name
    ribosomal protein L9provided by HGNC
    Primary source
    HGNC:HGNC:10369
    See related
    Ensembl:ENSG00000163682 MIM:603686; AllianceGenome:HGNC:10369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L9; uL6; NPC-A-16
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 1269.0), bone marrow (RPKM 646.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RPL9 in Genome Data Viewer
    Location:
    4p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (39454124..39458922, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (39423773..39428574, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (39455744..39460542, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 887, pseudogene Neighboring gene klotho beta Neighboring gene microRNA 5591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21458 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:39459543-39460293 Neighboring gene Sharpr-MPRA regulatory region 11886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21459 Neighboring gene lipoic acid synthetase Neighboring gene WD repeat domain 5C, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. A new human ribosomal protein sequence, homologue of rat L9. Hori N, et al. Nucleic Acids Res, 1993 Sep 11. PMID 8415001, Free PMC Article
    2. Investigating the folding mechanism of the N-terminal domain of ribosomal protein L9. Zhang H, et al. Proteins, 2021 Jul. PMID 33576138
    3. RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells. Li A, et al. Int J Oncol, 2024 Jun. PMID 38639179, Free PMC Article
    4. Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism. Lezzerini M, et al. Nucleic Acids Res, 2020 Jan 24. PMID 31799629, Free PMC Article
    5. Rabies virus phosphoprotein interacts with ribosomal protein L9 and affects rabies virus replication. Li Y, et al. Virology, 2016 Jan 15. PMID 26655239

    See all (224) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells.
      Title: RPL9 acts as an oncogene by shuttling miRNAs through exosomes in human hepatocellular carcinoma cells.
    2. Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis.
      Title: Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis.
    3. Investigating the folding mechanism of the N-terminal domain of ribosomal protein L9.
      Title: Investigating the folding mechanism of the N-terminal domain of ribosomal protein L9.
    4. Here we report an individual diagnosed with DBA carrying a variant in the 5'UTR of RPL9 (uL6). Additionally, we report two individuals from a family with multiple cancer incidences carrying a RPL9 missense variant
      Title: Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism.
    5. UNR could bind to the 3'UTR of PTEN and RPL9 in glioma cell lines, therefore promoting glioma cell migration and regulating the expression of RPL9.
      Title: RNA-binding Protein UNR Promotes Glioma Cell Migration and Regulates the Expression of Ribosomal Protein L9.
    6. High RPL9 expression is associated with colorectal carcinoma.
      Title: Knockdown of RPL9 expression inhibits colorectal carcinoma growth via the inactivation of Id-1/NF-κB signaling axis.
    7. The authors propose that during rabies virus infection, viral phosphoprotein P binds to ribosomal protein L9 that translocates from the nucleus to the cytoplasm, inhibiting the initial stage of viral transcription.
      Title: Rabies virus phosphoprotein interacts with ribosomal protein L9 and affects rabies virus replication.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L9 (RPL9) at amino acid residues 42-43 and 45-46 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ27456, MGC15545, DKFZp313J1510

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit HDA PubMed 
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL6
    Names
    60S ribosomal protein L9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052985.1 RefSeqGene

      Range
      5027..9825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1142

    mRNA and Protein(s)

    1. NM_000661.5 → NP_000652.2  large ribosomal subunit protein uL6

      See identical proteins and their annotated locations for NP_000652.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and the predominant variant. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC031906, BC066318, BM841336
      Consensus CDS
      CCDS3452.1
      UniProtKB/Swiss-Prot
      P32969
      UniProtKB/TrEMBL
      A0A024R9U2, D6RAN4, Q53Z07
      Related
      ENSP00000346022.7, ENST00000295955.14
      Conserved Domains (1) summary
      cl30086
      Location:1 → 191
      Ribosomal_L6; Ribosomal protein L6

    2. NM_001024921.4 → NP_001020092.1  large ribosomal subunit protein uL6

      See identical proteins and their annotated locations for NP_001020092.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternative splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL039355, AY376242, BC031906
      Consensus CDS
      CCDS3452.1
      UniProtKB/Swiss-Prot
      P32969
      UniProtKB/TrEMBL
      A0A024R9U2, D6RAN4, Q53Z07
      Related
      ENSP00000494697.1, ENST00000645496.2
      Conserved Domains (1) summary
      cl30086
      Location:1 → 191
      Ribosomal_L6; Ribosomal protein L6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      39454124..39458922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      39423773..39428574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32969.1 GenPept UniProtKB/Swiss-Prot:P32969

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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