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    MST1R macrophage stimulating 1 receptor [ Homo sapiens (human) ]

    Gene ID: 4486, updated on 10-Dec-2024

    Summary

    Official Symbol
    MST1Rprovided by HGNC
    Official Full Name
    macrophage stimulating 1 receptorprovided by HGNC
    Primary source
    HGNC:HGNC:7381
    See related
    Ensembl:ENSG00000164078 MIM:600168; AllianceGenome:HGNC:7381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RON; SEA; PTK8; CD136; NPCA3; CDw136; p185-Ron
    Summary
    This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in skin (RPKM 17.5), stomach (RPKM 16.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MST1R in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (49887002..49903873, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (49916899..49933769, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49924435..49941306, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49905159-49906091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49906092-49907023 Neighboring gene RNA, 7SL, cytoplasmic 217, pseudogene Neighboring gene CaM kinase like vesicle associated Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49921589-49922090 Neighboring gene actin like 11, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49934943-49935443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49939657-49940330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:49940331-49941004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49941679-49942351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49949147-49949724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14377 Neighboring gene MON1 homolog A, secretory trafficking associated Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49977213-49977735 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49977736-49978257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14379 Neighboring gene RNA binding motif protein 6 Neighboring gene NANOG hESC enhancer GRCh37_chr3:50050258-50050926

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (11 hits/1294 screens)

    Associated conditions

    Description Tests
    Nasopharyngeal carcinoma, susceptibility to, 3
    MedGen: C4310729 OMIM: 617075 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Tat trans activation domain and the integrity of the kinase domain of RON receptor are required for Tat-mediated degradation of RON PubMed
    tat Tat decreases cell surface RON expression in HIV-infected monocytic cells, and this Tat-mediated degradation of RON protein is blocked by inhibitors of proteasome activity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables enzyme binding PubMed 
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein tyrosine kinase collagen receptor activity  
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell migration  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in defense response PubMed 
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in innate immune response  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in multicellular organism development  
    involved_in nervous system development  
    involved_in phagocytosis  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of MAP kinase activity PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in response to virus PubMed 
    involved_in signal transduction PubMed 
    involved_in single fertilization PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    part_of receptor complex  
    located_in stress fiber  
    located_in vacuole  

    General protein information

    Preferred Names
    macrophage-stimulating protein receptor
    Names
    MSP receptor
    PTK8 protein tyrosine kinase 8
    S13 avian erythroblastosis oncogene homolog
    S13 erythroblastosis oncogene homolog
    c-met-related tyrosine kinase
    NP_001231866.1
    NP_001305842.1
    NP_002438.2
    XP_005265227.2
    XP_011532041.1
    XP_011532042.1
    XP_011532043.1
    XP_011532044.1
    XP_011532045.1
    XP_011532046.1
    XP_047304118.1
    XP_047304119.1
    XP_047304120.1
    XP_047304121.1
    XP_047304122.1
    XP_047304123.1
    XP_047304124.1
    XP_047304125.1
    XP_047304126.1
    XP_047304127.1
    XP_047304128.1
    XP_047304129.1
    XP_047304130.1
    XP_047304131.1
    XP_047304132.1
    XP_047304133.1
    XP_047304134.1
    XP_047304135.1
    XP_047304136.1
    XP_054202561.1
    XP_054202562.1
    XP_054202563.1
    XP_054202564.1
    XP_054202565.1
    XP_054202566.1
    XP_054202567.1
    XP_054202568.1
    XP_054202569.1
    XP_054202570.1
    XP_054202571.1
    XP_054202572.1
    XP_054202573.1
    XP_054202574.1
    XP_054202575.1
    XP_054202576.1
    XP_054202577.1
    XP_054202578.1
    XP_054202579.1
    XP_054202580.1
    XP_054202581.1
    XP_054202582.1
    XP_054202583.1
    XP_054202584.1
    XP_054202585.1
    XP_054202586.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030322.1 RefSeqGene

      Range
      5001..21872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001244937.3 → NP_001231866.1  macrophage-stimulating protein receptor isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as isoform delta-Ron) missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC105935, AK303234, BU542597, CA503122, EU826584, X70040
      Consensus CDS
      CCDS58833.1
      UniProtKB/TrEMBL
      H7C3Z8
      Related
      ENSP00000341325.4, ENST00000344206.8
      Conserved Domains (7) summary
      smart00219
      Location:1036 → 1289
      TyrKc; Tyrosine kinase, catalytic domain
      cd11279
      Location:27 → 523
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:769 → 859
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:684 → 768
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:569 → 683
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1037 → 1298
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:526 → 565
      PSI; Plexin repeat
    2. NM_001318913.2 → NP_001305842.1  macrophage-stimulating protein receptor isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 1.
      Source sequence(s)
      AC105935, CA503122, JN983806
      Consensus CDS
      CCDS82777.1
      UniProtKB/TrEMBL
      G9JXB8
      Related
      ENSP00000482642.1, ENST00000621387.4
      Conserved Domains (7) summary
      smart00219
      Location:979 → 1232
      TyrKc; Tyrosine kinase, catalytic domain
      smart00429
      Location:663 → 753
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:578 → 662
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:463 → 577
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:980 → 1241
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:420 → 459
      PSI; Plexin repeat
      cl15693
      Location:27 → 426
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    3. NM_002447.4 → NP_002438.2  macrophage-stimulating protein receptor isoform 1 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as isoform Ron).
      Source sequence(s)
      AC105935, CA503122, X70040
      Consensus CDS
      CCDS2807.1
      UniProtKB/Swiss-Prot
      A0A087WZG2, B5A944, B5A945, B5A946, B5A947, Q04912
      UniProtKB/TrEMBL
      H7C3Z8
      Related
      ENSP00000296474.3, ENST00000296474.8
      Conserved Domains (6) summary
      cd11279
      Location:27 → 523
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:769 → 859
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:684 → 768
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:569 → 683
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1086 → 1347
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:526 → 565
      PSI; Plexin repeat

    RNA

    1. NR_134919.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105935, CA503122, HQ908652, JN983806
      Related
      ENST00000714252.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      49887002..49903873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448174.1 → XP_047304130.1  macrophage-stimulating protein receptor isoform X20

      UniProtKB/TrEMBL
      G9JXB8
    2. XM_047448176.1 → XP_047304132.1  macrophage-stimulating protein receptor isoform X22

      UniProtKB/TrEMBL
      G9JXB8
    3. XM_047448177.1 → XP_047304133.1  macrophage-stimulating protein receptor isoform X23

      UniProtKB/TrEMBL
      G9JXB8
    4. XM_047448173.1 → XP_047304129.1  macrophage-stimulating protein receptor isoform X19

      UniProtKB/TrEMBL
      G9JXB8
    5. XM_047448175.1 → XP_047304131.1  macrophage-stimulating protein receptor isoform X21

      UniProtKB/TrEMBL
      G9JXB8
    6. XM_011533744.3 → XP_011532046.1  macrophage-stimulating protein receptor isoform X11

      UniProtKB/TrEMBL
      G9JXB8
      Conserved Domains (7) summary
      smart00219
      Location:980 → 1233
      TyrKc; Tyrosine kinase, catalytic domain
      smart00429
      Location:663 → 754
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:578 → 662
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:463 → 577
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:981 → 1242
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:420 → 459
      PSI; Plexin repeat
      cl15693
      Location:27 → 426
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    7. XM_047448168.1 → XP_047304124.1  macrophage-stimulating protein receptor isoform X14

      UniProtKB/TrEMBL
      H7C3Z8
    8. XM_047448170.1 → XP_047304126.1  macrophage-stimulating protein receptor isoform X16

      UniProtKB/TrEMBL
      H7C3Z8
    9. XM_047448166.1 → XP_047304122.1  macrophage-stimulating protein receptor isoform X12

      UniProtKB/TrEMBL
      H7C3Z8
    10. XM_047448162.1 → XP_047304118.1  macrophage-stimulating protein receptor isoform X3

      UniProtKB/TrEMBL
      H7C3Z8
    11. XM_047448171.1 → XP_047304127.1  macrophage-stimulating protein receptor isoform X17

      UniProtKB/TrEMBL
      H7C3Z8
    12. XM_047448163.1 → XP_047304119.1  macrophage-stimulating protein receptor isoform X6

      UniProtKB/TrEMBL
      H7C074, H7C3Z8
      Related
      ENSP00000393294.2, ENST00000434765.6
    13. XM_047448165.1 → XP_047304121.1  macrophage-stimulating protein receptor isoform X10

      UniProtKB/TrEMBL
      H7C3Z8
    14. XM_047448164.1 → XP_047304120.1  macrophage-stimulating protein receptor isoform X8

      UniProtKB/TrEMBL
      H7C3Z8
    15. XM_047448167.1 → XP_047304123.1  macrophage-stimulating protein receptor isoform X13

      UniProtKB/TrEMBL
      H7C3Z8
    16. XM_047448172.1 → XP_047304128.1  macrophage-stimulating protein receptor isoform X18

      UniProtKB/TrEMBL
      H7C3Z8
    17. XM_047448169.1 → XP_047304125.1  macrophage-stimulating protein receptor isoform X15

      UniProtKB/TrEMBL
      H7C3Z8
    18. XM_011533740.3 → XP_011532042.1  macrophage-stimulating protein receptor isoform X4

      UniProtKB/TrEMBL
      H7C3Z8
      Conserved Domains (7) summary
      smart00219
      Location:1037 → 1290
      TyrKc; Tyrosine kinase, catalytic domain
      cd11279
      Location:27 → 523
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:769 → 860
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:684 → 768
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:569 → 683
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1038 → 1299
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:526 → 565
      PSI; Plexin repeat
    19. XM_011533739.3 → XP_011532041.1  macrophage-stimulating protein receptor isoform X2

      UniProtKB/TrEMBL
      H7C3Z8
      Conserved Domains (7) summary
      smart00219
      Location:1046 → 1299
      TyrKc; Tyrosine kinase, catalytic domain
      cd11279
      Location:27 → 523
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:769 → 860
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:684 → 768
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:569 → 683
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1047 → 1308
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:526 → 565
      PSI; Plexin repeat
    20. XM_011533741.3 → XP_011532043.1  macrophage-stimulating protein receptor isoform X5

      UniProtKB/TrEMBL
      H7C3Z8
      Conserved Domains (7) summary
      smart00219
      Location:1021 → 1270
      TyrKc; Tyrosine kinase, catalytic domain
      cd11279
      Location:27 → 523
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:769 → 860
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:684 → 768
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:569 → 683
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1021 → 1279
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:526 → 565
      PSI; Plexin repeat
    21. XM_011533743.3 → XP_011532045.1  macrophage-stimulating protein receptor isoform X9

      UniProtKB/TrEMBL
      H7C3Z8
      Conserved Domains (6) summary
      cd11279
      Location:27 → 523
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:769 → 860
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:684 → 768
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:569 → 683
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:526 → 565
      PSI; Plexin repeat
      cl21453
      Location:1087 → 1247
      PKc_like; Protein Kinases, catalytic domain
    22. XM_011533742.3 → XP_011532044.1  macrophage-stimulating protein receptor isoform X7

      UniProtKB/TrEMBL
      H7C3Z8
      Conserved Domains (6) summary
      cd11279
      Location:27 → 523
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:769 → 860
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:684 → 768
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:569 → 683
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:526 → 565
      PSI; Plexin repeat
      cl21453
      Location:1087 → 1271
      PKc_like; Protein Kinases, catalytic domain
    23. XM_005265170.5 → XP_005265227.2  macrophage-stimulating protein receptor isoform X1

      UniProtKB/TrEMBL
      H7C3Z8
      Conserved Domains (7) summary
      smart00219
      Location:1086 → 1339
      TyrKc; Tyrosine kinase, catalytic domain
      cd11279
      Location:27 → 523
      Sema_RON; The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase
      smart00429
      Location:769 → 860
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:684 → 768
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:569 → 683
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1087 → 1348
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:526 → 565
      PSI; Plexin repeat
    24. XM_047448178.1 → XP_047304134.1  macrophage-stimulating protein receptor isoform X24

      UniProtKB/TrEMBL
      A0AAQ5BHX4
      Related
      ENSP00000407926.2, ENST00000411578.6
    25. XM_047448179.1 → XP_047304135.1  macrophage-stimulating protein receptor isoform X25

      UniProtKB/TrEMBL
      J3KQS7
    26. XM_047448180.1 → XP_047304136.1  macrophage-stimulating protein receptor isoform X26

      UniProtKB/TrEMBL
      J3KQS7
      Related
      ENST00000468525.5

    RNA

    1. XR_001740155.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      49916899..49933769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346605.1 → XP_054202580.1  macrophage-stimulating protein receptor isoform X20

      UniProtKB/TrEMBL
      G9JXB8
    2. XM_054346607.1 → XP_054202582.1  macrophage-stimulating protein receptor isoform X22

      UniProtKB/TrEMBL
      G9JXB8
    3. XM_054346608.1 → XP_054202583.1  macrophage-stimulating protein receptor isoform X23

      UniProtKB/TrEMBL
      G9JXB8
    4. XM_054346604.1 → XP_054202579.1  macrophage-stimulating protein receptor isoform X19

      UniProtKB/TrEMBL
      G9JXB8
    5. XM_054346606.1 → XP_054202581.1  macrophage-stimulating protein receptor isoform X21

      UniProtKB/TrEMBL
      G9JXB8
    6. XM_054346596.1 → XP_054202571.1  macrophage-stimulating protein receptor isoform X11

      UniProtKB/TrEMBL
      G9JXB8
    7. XM_054346599.1 → XP_054202574.1  macrophage-stimulating protein receptor isoform X14

      UniProtKB/TrEMBL
      H7C3Z8
    8. XM_054346601.1 → XP_054202576.1  macrophage-stimulating protein receptor isoform X16

      UniProtKB/TrEMBL
      H7C3Z8
    9. XM_054346597.1 → XP_054202572.1  macrophage-stimulating protein receptor isoform X12

      UniProtKB/TrEMBL
      H7C3Z8
    10. XM_054346588.1 → XP_054202563.1  macrophage-stimulating protein receptor isoform X3

      UniProtKB/TrEMBL
      H7C3Z8
    11. XM_054346602.1 → XP_054202577.1  macrophage-stimulating protein receptor isoform X17

      UniProtKB/TrEMBL
      H7C3Z8
    12. XM_054346591.1 → XP_054202566.1  macrophage-stimulating protein receptor isoform X6

      UniProtKB/TrEMBL
      H7C3Z8
    13. XM_054346595.1 → XP_054202570.1  macrophage-stimulating protein receptor isoform X10

      UniProtKB/TrEMBL
      H7C3Z8
    14. XM_054346593.1 → XP_054202568.1  macrophage-stimulating protein receptor isoform X8

      UniProtKB/TrEMBL
      H7C3Z8
    15. XM_054346598.1 → XP_054202573.1  macrophage-stimulating protein receptor isoform X13

      UniProtKB/TrEMBL
      H7C3Z8
    16. XM_054346603.1 → XP_054202578.1  macrophage-stimulating protein receptor isoform X18

      UniProtKB/TrEMBL
      H7C3Z8
    17. XM_054346600.1 → XP_054202575.1  macrophage-stimulating protein receptor isoform X15

      UniProtKB/TrEMBL
      H7C3Z8
    18. XM_054346587.1 → XP_054202562.1  macrophage-stimulating protein receptor isoform X2

      UniProtKB/TrEMBL
      H7C3Z8
    19. XM_054346594.1 → XP_054202569.1  macrophage-stimulating protein receptor isoform X9

      UniProtKB/TrEMBL
      H7C3Z8
    20. XM_054346592.1 → XP_054202567.1  macrophage-stimulating protein receptor isoform X7

      UniProtKB/TrEMBL
      H7C3Z8
    21. XM_054346589.1 → XP_054202564.1  macrophage-stimulating protein receptor isoform X4

      UniProtKB/TrEMBL
      H7C3Z8
    22. XM_054346590.1 → XP_054202565.1  macrophage-stimulating protein receptor isoform X5

      UniProtKB/TrEMBL
      H7C3Z8
    23. XM_054346586.1 → XP_054202561.1  macrophage-stimulating protein receptor isoform X1

      UniProtKB/TrEMBL
      H7C3Z8
    24. XM_054346609.1 → XP_054202584.1  macrophage-stimulating protein receptor isoform X24

      UniProtKB/TrEMBL
      A0AAQ5BHX4
    25. XM_054346610.1 → XP_054202585.1  macrophage-stimulating protein receptor isoform X25

      UniProtKB/TrEMBL
      J3KQS7
    26. XM_054346611.1 → XP_054202586.1  macrophage-stimulating protein receptor isoform X26

      UniProtKB/TrEMBL
      J3KQS7

    RNA

    1. XR_008486718.1 RNA Sequence

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