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    fln-2 Calponin-homology (CH) domain-containing protein;Filamin-A;ZM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181168, updated on 9-Dec-2024

    Summary

    Official Symbol
    fln-2
    Official Full Name
    Calponin-homology (CH) domain-containing protein;Filamin-A;ZM domain-containing protein
    Primary source
    WormBase:WBGene00016006
    Locus tag
    CELE_C23F12.1
    See related
    AllianceGenome:WB:WBGene00016006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in organelle. Is expressed in several structures, including anal depressor muscle; distal tip cell; excretory canal; hypodermis; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See fln-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    53
    Sequence:
    Chromosome: X; NC_003284.9 (9397701..9427247)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Zinc finger, CCHC-type Neighboring gene Transposase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene putative 3-hydroxyacyl-CoA dehydrogenase B0272.3

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in organelle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Calponin-homology (CH) domain-containing protein;Filamin-A;ZM domain-containing protein
    NP_001257074.2
    • Confirmed by transcript evidence
    NP_001257075.2
    • Confirmed by transcript evidence
    NP_001300321.1
    • Confirmed by transcript evidence
    NP_001300323.1
    • Confirmed by transcript evidence
    NP_001300324.1
    • Confirmed by transcript evidence
    NP_001300325.1
    • Confirmed by transcript evidence
    NP_001300326.1
    • Confirmed by transcript evidence
    NP_001300327.1
    • Confirmed by transcript evidence
    NP_001300328.1
    • Confirmed by transcript evidence
    NP_001300329.1
    • Confirmed by transcript evidence
    NP_001300330.1
    • Confirmed by transcript evidence
    NP_001300331.1
    • Confirmed by transcript evidence
    NP_001300332.1
    • Confirmed by transcript evidence
    NP_001359882.1
    • Confirmed by transcript evidence
    NP_001360405.1
    • Confirmed by transcript evidence
    NP_001360663.1
    • Confirmed by transcript evidence
    NP_001360664.1
    • Confirmed by transcript evidence
    NP_001360665.1
    • Confirmed by transcript evidence
    NP_001360666.1
    • Confirmed by transcript evidence
    NP_001360667.1
    • Confirmed by transcript evidence
    NP_001360668.1
    • Confirmed by transcript evidence
    NP_001368576.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9397701..9427247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373422.1NP_001359882.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0VWL6
      Conserved Domains (6) summary
      PTZ00121
      Location:15061928
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:34453539
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:29333019
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:25892652
      Filamin; Filamin/ABP280 repeat
    2. NM_001373425.2NP_001360405.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AT74
      Conserved Domains (5) summary
      PTZ00121
      Location:14751897
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:30603154
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:25482634
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    3. NM_001373423.2NP_001360663.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK09
      Conserved Domains (5) summary
      PTZ00121
      Location:15061928
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:30913185
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:25792665
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    4. NM_001373424.2NP_001360664.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKI4
      Conserved Domains (6) summary
      PTZ00121
      Location:14751897
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:34143508
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:29022988
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:25582621
      Filamin; Filamin/ABP280 repeat
    5. NM_001373426.2NP_001360665.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INA2
      Conserved Domains (6) summary
      PTZ00121
      Location:14781900
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:34173511
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:29052991
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:762826
      Filamin; Filamin/ABP280 repeat
    6. NM_001373427.2NP_001360666.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IN32
      Conserved Domains (6) summary
      PTZ00121
      Location:14781900
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:30633157
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:25512637
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:762826
      Filamin; Filamin/ABP280 repeat
    7. NM_001373428.2NP_001360667.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V6M3C1
      Conserved Domains (6) summary
      PTZ00121
      Location:14471869
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:33863480
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:28742960
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:762826
      Filamin; Filamin/ABP280 repeat
    8. NM_001373429.2NP_001360668.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK63
      Conserved Domains (6) summary
      PTZ00121
      Location:14471869
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:30323126
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:11242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      pfam00630
      Location:25202606
      Filamin; Filamin/ABP280 repeat
      cl00030
      Location:235327
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl27659
      Location:762826
      Filamin; Filamin/ABP280 repeat
    9. NM_001381052.2NP_001368576.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASM8
      Conserved Domains (3) summary
      PTZ00121
      Location:138560
      PTZ00121; MAEBL; Provisional
      smart00557
      Location:17231817
      IG_FLMN; Filamin-type immunoglobulin domains
      cl27659
      Location:12311304
      Filamin; Filamin/ABP280 repeat
    10. NM_001313394.3NP_001300323.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AW96
      Conserved Domains (3) summary
      smart00557
      Location:28732967
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:28702960
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:689879
      DUF4584; Domain of unknown function (DUF4584)
    11. NM_001313395.3NP_001300324.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AYH6
      Conserved Domains (2) summary
      smart00557
      Location:24882582
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:24852575
      Filamin; Filamin/ABP280 repeat
    12. NM_001313396.3NP_001300325.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AT80
      Conserved Domains (3) summary
      smart00557
      Location:26982792
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:26952785
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:514704
      DUF4584; Domain of unknown function (DUF4584)
    13. NM_001313397.3NP_001300326.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVH8
      Conserved Domains (2) summary
      smart00557
      Location:23132407
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:23102400
      Filamin; Filamin/ABP280 repeat
    14. NM_001270146.3NP_001257075.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0VWL8
      Conserved Domains (2) summary
      smart00557
      Location:22252319
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:22222312
      Filamin; Filamin/ABP280 repeat
    15. NM_001270145.4NP_001257074.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0VWL7
      Conserved Domains (3) summary
      smart00557
      Location:26102704
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:26072697
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:426616
      DUF4584; Domain of unknown function (DUF4584)
    16. NM_001313398.3NP_001300327.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASN4
      Conserved Domains (3) summary
      smart00557
      Location:25542648
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:25512641
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:370560
      DUF4584; Domain of unknown function (DUF4584)
    17. NM_001313399.3NP_001300328.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWA2
      Conserved Domains (2) summary
      smart00557
      Location:21692263
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:21662256
      Filamin; Filamin/ABP280 repeat
    18. NM_001313400.3NP_001300329.1  Filamin-A [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AYI1
      Conserved Domains (3) summary
      smart00557
      Location:24902584
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:24872577
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:306496
      DUF4584; Domain of unknown function (DUF4584)
    19. NM_001313401.3NP_001300330.1  Filamin-A [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AT86
      Conserved Domains (2) summary
      smart00557
      Location:21052199
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:21022192
      Filamin; Filamin/ABP280 repeat
    20. NM_001313402.3NP_001300331.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVI4
      Conserved Domains (3) summary
      smart00557
      Location:22492343
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:22462336
      Filamin; Filamin/ABP280 repeat
      pfam15223
      Location:65255
      DUF4584; Domain of unknown function (DUF4584)
    21. NM_001313403.3NP_001300332.1  ZM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASN9
      Conserved Domains (2) summary
      smart00557
      Location:18641958
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:18611951
      Filamin; Filamin/ABP280 repeat
    22. NM_001313392.3NP_001300321.1  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVH5
      Conserved Domains (2) summary
      smart00557
      Location:20772171
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:20742164
      Filamin; Filamin/ABP280 repeat

    RNA

    1. NR_132548.1 RNA Sequence

      Status: REVIEWED