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    POTEF POTE ankyrin domain family member F [ Homo sapiens (human) ]

    Gene ID: 728378, updated on 10-Dec-2024

    Summary

    Official Symbol
    POTEFprovided by HGNC
    Official Full Name
    POTE ankyrin domain family member Fprovided by HGNC
    Primary source
    HGNC:HGNC:33905
    See related
    Ensembl:ENSG00000196604 AllianceGenome:HGNC:33905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACTB; A26C1B; POTEACTIN; POTE2alpha
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in axonogenesis and cell motility. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 2.4), prostate (RPKM 1.0) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See POTEF in Genome Data Viewer
    Location:
    2q21.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130073535..130129222, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (130496742..130563302, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (130831108..130886795, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fatty acyl-CoA reductase 2 pseudogene 1 Neighboring gene Kruppel like factor 2 pseudogene 1 Neighboring gene cytochrome P450 family 4 subfamily F member 27, pseudogene Neighboring gene RNA, U6 small nuclear 1049, pseudogene Neighboring gene POTEF antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:130886707-130887281 Neighboring gene mediator complex subunit 15 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16521 Neighboring gene coiled-coil domain containing 74B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:130917957-130918586 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:130921824-130922007 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:130938087-130938883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11953 Neighboring gene mitotic spindle organizing protein 2B

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human POTE ankyrin domain family, member F (POTEF) at amino acid residues 7-8 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of postsynaptic actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in postsynaptic actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in blood microparticle HDA PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    POTE ankyrin domain family member F
    Names
    ANKRD26-like family C member 1B
    POTE-2 alpha-actin
    beta actin
    chimeric POTE-actin protein
    prostate, ovary, testis expressed protein on chromosome 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099771.2NP_001093241.1  POTE ankyrin domain family member F

      See identical proteins and their annotated locations for NP_001093241.1

      Status: VALIDATED

      Source sequence(s)
      AC018804, AC018865
      Consensus CDS
      CCDS46409.1
      UniProtKB/Swiss-Prot
      A5A3E0, A6NC34
      Related
      ENSP00000386786.2, ENST00000409914.7
      Conserved Domains (6) summary
      smart00268
      Location:7051074
      ACTIN; Actin
      cd00204
      Location:167292
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:177269
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:143193
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:238269
      ANK; ANK repeat [structural motif]
      cl17037
      Location:7011075
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      130073535..130129222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047445721.1XP_047301677.1  POTE ankyrin domain family member F isoform X2

      UniProtKB/Swiss-Prot
      A5A3E0, A6NC34
    2. XM_017004833.2XP_016860322.1  POTE ankyrin domain family member F isoform X1

    3. XM_017004834.2XP_016860323.1  POTE ankyrin domain family member F isoform X3

    4. XM_017004835.2XP_016860324.1  POTE ankyrin domain family member F isoform X4

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791762.1 Reference GRCh38.p14 PATCHES

      Range
      241401..305918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332885.1XP_054188860.1  POTE ankyrin domain family member F isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      130496742..130563302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343706.1XP_054199681.1  POTE ankyrin domain family member F isoform X2

    2. XM_054343705.1XP_054199680.1  POTE ankyrin domain family member F isoform X5

      UniProtKB/TrEMBL
      A0A087X187