dally division abnormally delayed [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dallyprovided by FlyBase
Official Full Name: division abnormally delayedprovided by FlyBase
Primary source: FLYBASE:FBgn0263930
Locus tag: Dmel_CG4974
See related: AllianceGenome:FB:FBgn0263930
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-1.63; CG4974; clone 1.63; CT15952; Dally; Dmel\CG4974; gem; l(3)06464; l(3)SG18
Summary: Involved in several processes, including imaginal disc-derived appendage morphogenesis; regionalization; and regulation of signal transduction. Located in apical plasma membrane; basolateral plasma membrane; and external side of plasma membrane. Is expressed in several structures, including adult brain; compartment boundary; cuboidal/columnar epithelium; imaginal disc; and somatic cell of ovariole. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Orthologous to several human genes including GPC5 (glypican 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66E1-66E3; 3-27 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8827505..8891192)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8820605..8884292)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization.
Title: Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization.
Dally and Dally-like, are necessary for injury-induced thermal allodynia
Title: Glypicans Dally and Dally-like control injury-induced allodynia in Drosophila.
dally is essential for normal follicle stem cell maintenance.
Title: Drosophila Glypicans Regulate Follicle Stem Cell Maintenance and Niche Competition.
ECM over planar cell polarity mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cytonemes navigated in the Dally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer, requiring Dlp (but not Dally).
Title: Cells must express components of the planar cell polarity system and extracellular matrix to support cytonemes.
Autonomous and nonautonomous effects on Drosophila tissue growth rely on the up-regulation of the proteoglycan Dally. Dally also contributes to integrating nutrient sensing and organ scaling, the fitting of pattern to size.
Title: Dally Proteoglycan Mediates the Autonomous and Nonautonomous Effects on Tissue Growth Caused by Activation of the PI3K and TOR Pathways.
analysis of balancing between hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif
Title: Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif.
data suggest that Dally and Dlp are essential regulators for Upd distribution and JAK/STAT signaling activity in eye development
Title: Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development.
findings demonstrate that the glypican dally regulates formation of the follicular gradient of the Upd morphogen, Upd
Title: Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen.
Dally is necessary to sequester Hedgehog at the cell surface and to promote Hedgehog internalisation with its receptor.
Title: Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling.
DALLY regulates DPP signaling in trans by its effect on the stability of DPP protein on the surface of the contacting cells
Title: Novel contact-dependent bone morphogenetic protein (BMP) signaling mediated by heparan sulfate proteoglycans.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of protein localization to extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location in extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of semaphorin-plexin signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ boundary specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc anterior/posterior pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in perivitelline space	HDA more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: division abnormally delayed

Names: CG4974-PA; CG4974-PB; dally; dally-PA; dally-PB; genitalia missing; lethal (3) SG18

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8827505..8891192

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259756.2 → NP_001246685.1 division abnormally delayed, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246685.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24114, Q9VSQ8

UniProtKB/TrEMBL

Q53XG2, Q966V5

Conserved Domains (1) summary

pfam01153
Location:51 → 622

Glypican; Glypican
NM_079259.4 → NP_523983.1 division abnormally delayed, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523983.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24114, Q9VSQ8

UniProtKB/TrEMBL

Q53XG2, Q966V5

Related

FBpp0076310

Conserved Domains (1) summary

pfam01153
Location:51 → 622

Glypican; Glypican