U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Abca3 ATP binding cassette subfamily A member 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33103, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Abca3provided by FlyBase
    Official Full Name
    ATP binding cassette subfamily A member 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0031170
    Locus tag
    Dmel_CG1718
    See related
    AllianceGenome:FB:FBgn0031170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ABCA; CG1718; dABCA; DmCG1718; Dmel\CG1718
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head and organism. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human ABCA3 (ATP binding cassette subfamily A member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Abca3 in Genome Data Viewer
    Location:
    19F3-19F3; 1-65 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21292308..21306665, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21163335..21177692, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Membrane-bound Notch regulator Neighboring gene transfer RNA:Arginine-TCG 2-2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Tyrosine-GTA 1-1 Neighboring gene transfer RNA:Tyrosine-GTA 2-1 Neighboring gene mir-1007 stem loop Neighboring gene mir-2535b stem loop Neighboring gene uncharacterized protein Neighboring gene SRA stem-loop interacting RNA binding protein 1 Neighboring gene Regulatory particle triple-A ATPase 6 Neighboring gene anorexia

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Novel Drosophila model for psychiatric disorders including autism spectrum disorder by targeting of ATP-binding cassette protein A. Ueoka I, et al. Exp Neurol, 2018 Feb. PMID 29092799
    2. The ABC Transporter Eato Promotes Cell Clearance in the Drosophila melanogaster Ovary. Santoso CS, et al. G3 (Bethesda), 2018 Mar 2. PMID 29295819, Free PMC Article
    3. Novel genetic link between the ATP-binding cassette subfamily A gene and hippo gene in Drosophila. Ueoka I, et al. Exp Cell Res, 2020 Jan 15. PMID 31751555
    4. Induction of Apoptosis and Subsequent Phagocytosis of Virus-Infected Cells As an Antiviral Mechanism. Nainu F, et al. Front Immunol, 2017. PMID 29033939, Free PMC Article
    5. Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes. Moulton MJ, et al. Proc Natl Acad Sci U S A, 2021 Dec 28. PMID 34949639, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel genetic link between the ATP-binding cassette subfamily A gene and hippo gene in Drosophila has been documented.
      Title: Novel genetic link between the ATP-binding cassette subfamily A gene and hippo gene in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATP binding cassette subfamily A member 3
    Names
    ATP binding cassette subfamily A
    Abca3-PB
    Abca3-PC
    Abca3-PD
    CG1718-PB
    CG1718-PC
    CG1718-PD
    NP_001259764.1
    NP_001259765.1
    NP_608445.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21292308..21306665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134601.3 → NP_608445.2  ATP binding cassette subfamily A member 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608445.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRG4
      Conserved Domains (5) summary
      TIGR01188
      Location:1376 → 1702
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:538 → 755
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:538 → 843
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:913 → 1316
      ABC2_membrane_3; ABC-2 family transporter protein
      pfam12730
      Location:254 → 434
      ABC2_membrane_4; ABC-2 family transporter protein

    2. NM_001272836.1 → NP_001259765.1  ATP binding cassette subfamily A member 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259765.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHQ1
      Conserved Domains (5) summary
      TIGR01188
      Location:1354 → 1680
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:516 → 733
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:516 → 821
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:891 → 1294
      ABC2_membrane_3; ABC-2 family transporter protein
      pfam12730
      Location:232 → 412
      ABC2_membrane_4; ABC-2 family transporter protein

    3. NM_001272835.1 → NP_001259764.1  ATP binding cassette subfamily A member 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259764.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFD0
      Conserved Domains (5) summary
      TIGR01188
      Location:1354 → 1680
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:516 → 733
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      COG1131
      Location:516 → 821
      CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
      pfam12698
      Location:891 → 1294
      ABC2_membrane_3; ABC-2 family transporter protein
      pfam12730
      Location:232 → 412
      ABC2_membrane_4; ABC-2 family transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFD0 M9PFD0
    M9PHQ1 M9PHQ1
    Q9VRG4 Q9VRG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous