Camta Calmodulin-binding transcription activator [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Camtaprovided by FlyBase
Official Full Name: Calmodulin-binding transcription activatorprovided by FlyBase
Primary source: FLYBASE:FBgn0287478
Locus tag: Dmel_CG42332
See related: AllianceGenome:FB:FBgn0287478
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: camta; CG13952; CG13953; CG42332; CG8809; cro; dCAMTA; DmCAMTA; Dmel\CG42332; tes
Old locus tag: Dmel_CG13952; Dmel_CG13953; Dmel_CG8809
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; calmodulin binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to calcium ion; negative regulation of opsin-mediated signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic Malpighian tubule; ganglia; and gut section. Human ortholog(s) of this gene implicated in nonprogressive cerebellar ataxia with mental retardation. Orthologous to several human genes including CAMTA2 (calmodulin binding transcription activator 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 45D8-45E1; 2-60 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9446046..9480076)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5333551..5367581)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal calmodulin levels are controlled by CAMTA transcription factors.
Title: Neuronal calmodulin levels are controlled by CAMTA transcription factors.
Study presented evidence that the polycyclic distortion of pulse song in cro mutant males originates from defects in the fru-labeled circuit underlying male courtship behavior.
Title: Calmodulin-binding transcription factor shapes the male courtship song in Drosophila.
dCAMTA may function as a dimer during fly visual regulation and that the CG-1 domain may mediate dimerization of CAMTA transcription factors
Title: A potential dimerization region of dCAMTA is critical for termination of fly visual response.
Calmodulin/CAMTA/Fbxl4 may mediate a long-term feedback regulation of the activity of Ca(2+)-stimulating G protein-coupled receptor, which could prevent cell damage due to extra Ca(2+) influx.
Title: The fly CAMTA transcription factor potentiates deactivation of rhodopsin, a G protein-coupled light receptor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Calmodulin-binding transcription activator

Names: CG42332-PB; CG42332-PD; CG42332-PE; CG42332-PF; CG42332-PG; CG42332-PH; CG42332-PI; Calmodulin-binding transcription factor; Camta-PB; Camta-PD; Camta-PE; Camta-PF; Camta-PG; Camta-PH; Camta-PI; calmodulin-binding transcription activator; croaker

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

9446046..9480076

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144152.2 → NP_001137624.1 Calmodulin-binding transcription activator, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137624.1

Status: REVIEWED

UniProtKB/TrEMBL

A0SQK5, B7YZU4

Conserved Domains (5) summary

smart01076
Location:422 → 538

CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues

cd00204
Location:1405 → 1497

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam01833
Location:1242 → 1319

TIG; IPT/TIG domain

pfam12796
Location:1410 → 1500

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1405 → 1447

ANK; ANK repeat [structural motif]
NM_001144153.2 → NP_001137625.1 Calmodulin-binding transcription activator, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137625.1

Status: REVIEWED

UniProtKB/TrEMBL

A0SQK5, B7YZU5

Conserved Domains (5) summary

smart01076
Location:422 → 538

CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues

cd00204
Location:1405 → 1497

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam01833
Location:1242 → 1319

TIG; IPT/TIG domain

pfam12796
Location:1410 → 1500

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1405 → 1447

ANK; ANK repeat [structural motif]
NM_001299321.1 → NP_001286250.1 Calmodulin-binding transcription activator, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286250.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LF15, A0SQK5

Conserved Domains (5) summary

smart01076
Location:422 → 538

CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues

cd00204
Location:1404 → 1496

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam01833
Location:1241 → 1318

TIG; IPT/TIG domain

pfam12796
Location:1409 → 1499

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1404 → 1446

ANK; ANK repeat [structural motif]
NM_001169627.2 → NP_001163098.1 Calmodulin-binding transcription activator, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163098.1

Status: REVIEWED

UniProtKB/TrEMBL

A0SQK5, E1JH18

Conserved Domains (5) summary

smart01076
Location:422 → 538

CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues

cd00204
Location:1404 → 1496

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam01833
Location:1241 → 1318

TIG; IPT/TIG domain

pfam12796
Location:1409 → 1499

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1404 → 1446

ANK; ANK repeat [structural motif]
NM_136647.5 → NP_610491.4 Calmodulin-binding transcription activator, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610491.4

Status: REVIEWED

UniProtKB/TrEMBL

A1Z7V0

Conserved Domains (5) summary

smart01076
Location:259 → 375

CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues

cd00204
Location:1242 → 1334

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam01833
Location:1079 → 1156

TIG; IPT/TIG domain

pfam12796
Location:1247 → 1337

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1242 → 1284

ANK; ANK repeat [structural motif]
NM_001144154.2 → NP_001137626.1 Calmodulin-binding transcription activator, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137626.1

Status: REVIEWED

UniProtKB/TrEMBL

B7YZS4

Conserved Domains (5) summary

smart01076
Location:259 → 375

CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues

cd00204
Location:1242 → 1334

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam01833
Location:1079 → 1156

TIG; IPT/TIG domain

pfam12796
Location:1247 → 1337

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1242 → 1284

ANK; ANK repeat [structural motif]
NM_001299320.1 → NP_001286249.1 Calmodulin-binding transcription activator, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286249.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LF06

Conserved Domains (5) summary

smart01076
Location:54 → 170

CG-1; CG-1 domains are highly conserved domains of about 130 amino-acid residues

cd00204
Location:1036 → 1128

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam01833
Location:873 → 950

TIG; IPT/TIG domain

pfam12796
Location:1041 → 1131

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1036 → 1078

ANK; ANK repeat [structural motif]

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4LF06		A0A0B4LF06
A0A0B4LF15		A0A0B4LF15
A0SQK5		A0SQK5
A1Z7V0		A1Z7V0
B7YZS4		B7YZS4
B7YZU4		B7YZU4
B7YZU5		B7YZU5
E1JH18		E1JH18
Q95RQ6		Q95RQ6