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    sick sickie [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35277, updated on 9-Dec-2024

    Summary

    Official Symbol
    sickprovided by FlyBase
    Official Full Name
    sickieprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263873
    Locus tag
    Dmel_CG43720
    See related
    AllianceGenome:FB:FBgn0263873
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10662; CG13958; CG13959; CG13960; CG13961; CG13964; CG33316; CG34343; CG42589; CG43720; Dmel\CG43720; Dm_2L:104545
    Old locus tag
    CG10662; CG33316; Dmel_CG10662; Dmel_CG13958; Dmel_CG13964; Dmel_CG33316; Dmel_CG34343; Dmel_CG42589
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in several processes, including actin filament organization; defense response to Gram-negative bacterium; and positive regulation of peptidoglycan recognition protein signaling pathway. Is expressed in several structures, including adult heart; alpha/beta Kenyon cell; brain; larval imaginal tissue; and sensory nervous system primordium. Used to study cerebellar hypoplasia. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to several human genes including NAV2 (neuron navigator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See sick in Genome Data Viewer
    Location:
    38A3-38A8; 2-54 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19796365..19958424)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19796365..19958424)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cd GTPase activating protein-related Neighboring gene female sterile (2) ltoPP43 Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U5 at 38AB a Neighboring gene small nuclear RNA U2 at 38AB b Neighboring gene small nuclear RNA U4 at 38AB Neighboring gene small nuclear RNA U2 at 38AB a Neighboring gene small nuclear RNA U5 at 38AB b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43097 Neighboring gene long non-coding RNA:CR43828 Neighboring gene long non-coding RNA:CR43827 Neighboring gene long non-coding RNA:CR45183 Neighboring gene Turandot F Neighboring gene Turandot E Neighboring gene uncharacterized protein Neighboring gene Cytochrome c oxidase subunit 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    mobile_element

    • Loc: 19813239-19813515 mobile_element_type = transposon:INE-1{}4025
    • Loc: 19816785-19816819 mobile_element_type = transposon:INE-1{}4026

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  

    General protein information

    Preferred Names
    sickie
    Names
    CG43720-PB
    CG43720-PD
    CG43720-PE
    CG43720-PF
    CG43720-PG
    CG43720-PH
    CG43720-PI
    CG43720-PJ
    CG43720-PK
    CG43720-PL
    CG43720-PM
    CG43720-PN
    sick-PB
    sick-PD
    sick-PE
    sick-PF
    sick-PG
    sick-PH
    sick-PI
    sick-PJ
    sick-PK
    sick-PL
    sick-PM
    sick-PN

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19796365..19958424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273674.1 → NP_001260603.1  sickie, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260603.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBE4
      Conserved Domains (4) summary
      smart00033
      Location:21 → 122
      CH; Calponin homology domain
      smart00382
      Location:1867 → 2016
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1870 → 1961
      AAA_22; AAA domain
      pfam15688
      Location:240 → 332
      NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    2. NM_206008.4 → NP_995730.2  sickie, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995730.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VIQ9
      Conserved Domains (4) summary
      smart00033
      Location:5 → 106
      CH; Calponin homology domain
      smart00382
      Location:1851 → 2000
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1854 → 1945
      AAA_22; AAA domain
      pfam15688
      Location:224 → 316
      NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    3. NM_001273678.1 → NP_001260607.1  sickie, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA0
      Conserved Domains (3) summary
      smart00033
      Location:535 → 637
      CH; Calponin homology domain
      smart00382
      Location:2382 → 2531
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:2385 → 2476
      AAA_22; AAA domain
    4. NM_001273677.1 → NP_001260606.1  sickie, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260606.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA0
      Conserved Domains (3) summary
      smart00033
      Location:535 → 637
      CH; Calponin homology domain
      smart00382
      Location:2382 → 2531
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:2385 → 2476
      AAA_22; AAA domain
    5. NM_001273680.2 → NP_001260609.1  sickie, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD86
      Conserved Domains (4) summary
      smart00033
      Location:25 → 127
      CH; Calponin homology domain
      smart00382
      Location:1881 → 2030
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1884 → 1975
      AAA_22; AAA domain
      pfam15688
      Location:245 → 337
      NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    6. NM_206007.5 → NP_995729.2  sickie, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995729.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KT30, Q7KT31, Q9VIQ9
      Conserved Domains (4) summary
      smart00033
      Location:25 → 127
      CH; Calponin homology domain
      smart00382
      Location:1872 → 2021
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1875 → 1966
      AAA_22; AAA domain
      pfam15688
      Location:245 → 337
      NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    7. NM_001273681.1 → NP_001260610.1  sickie, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDS6
      Conserved Domains (3) summary
      smart00382
      Location:1668 → 1817
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1671 → 1762
      AAA_22; AAA domain
      pfam15688
      Location:41 → 133
      NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2
    8. NM_001273676.1 → NP_001260605.1  sickie, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260605.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDS2
      Conserved Domains (2) summary
      smart00382
      Location:1693 → 1842
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1696 → 1787
      AAA_22; AAA domain
    9. NM_001103713.4 → NP_001097183.1  sickie, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDS2
      Conserved Domains (2) summary
      smart00382
      Location:1693 → 1842
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1696 → 1787
      AAA_22; AAA domain
    10. NM_001273679.1 → NP_001260608.1  sickie, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBE5
      Conserved Domains (3) summary
      smart00382
      Location:1044 → 1193
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1047 → 1138
      AAA_22; AAA domain
      cl19863
      Location:657 → 768
      DUF935; Protein of unknown function (DUF935)
    11. NM_001273675.1 → NP_001260604.1  sickie, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260604.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIR0
      Conserved Domains (2) summary
      smart00382
      Location:1021 → 1170
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1024 → 1115
      AAA_22; AAA domain
    12. NM_136167.3 → NP_610011.2  sickie, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610011.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIR0
      Conserved Domains (2) summary
      smart00382
      Location:1021 → 1170
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1024 → 1115
      AAA_22; AAA domain
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