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    ND-B14 NADH dehydrogenase (ubiquinone) B14 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36159, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-B14provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) B14 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033570
    Locus tag
    Dmel_CG7712
    See related
    AllianceGenome:FB:FBgn0033570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE25411; CG7712; Dmel\CG7712; dNDUFA6; NB4M; NDUFA6
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly and response to oxidative stress. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; anterior endoderm; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 33. Orthologous to human NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-B14 in Genome Data Viewer
    Location:
    47C6-47C6; 2-63 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10897144..10897885, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6784649..6785390, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-1008 stem loop Neighboring gene uncharacterized protein Neighboring gene cag Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II, I and III subunit E Neighboring gene polyphemus

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model. Yu J, et al. Proc Natl Acad Sci U S A, 2022 Oct 11. PMID 36191230, Free PMC Article
    2. orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control. Fernandez-Acosta M, et al. BMC Biol, 2022 Oct 21. PMID 36266680, Free PMC Article
    3. Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. Yin S, et al. PLoS One, 2013. PMID 24069262, Free PMC Article
    4. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
    5. An antibody toolbox to track complex I assembly defines AIF's mitochondrial function. Murari A, et al. J Cell Biol, 2020 Oct 5. PMID 32936885, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) B14 subunit
    Names
    CG7712-PA
    CG7712-PB
    FBpp0087333
    NADH ubiquinone oxidoreductase B14
    NADH-ubiquinone oxidoreductase B14 subunit
    NADH:ubiquinone oxidoreductase B14 subunit
    ND-B14-PA
    ND-B14-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10897144..10897885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273948.1 → NP_001260877.1  NADH dehydrogenase (ubiquinone) B14 subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZK1
      Conserved Domains (1) summary
      cd20266
      Location:22 → 96
      Complex1_LYR_NDUFA6_LYRM6; LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) and similar proteins

    2. NM_136785.3 → NP_610629.1  NADH dehydrogenase (ubiquinone) B14 subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610629.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZK1
      Related
      FBpp0087333
      Conserved Domains (1) summary
      cd20266
      Location:22 → 96
      Complex1_LYR_NDUFA6_LYRM6; LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (NDUFA6) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JZK1 Q7JZK1

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