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    Mapkbp1 mitogen activated protein kinase binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362197, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mapkbp1provided by RGD
    Official Full Name
    mitogen activated protein kinase binding protein 1provided by RGD
    Primary source
    RGD:1307578
    See related
    EnsemblRapid:ENSRNOG00000007018 AllianceGenome:RGD:1307578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of defense response to bacterium; negative regulation of interleukin-8 production; and regulation of intracellular signal transduction. Predicted to be located in mitotic spindle pole; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nephronophthisis 20. Orthologous to human MAPKBP1 (mitogen-activated protein kinase binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 69.2), Testes (RPKM 62.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mapkbp1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127401612..127452152)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106947342..106998368)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111767126..111817103)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene GABA type A receptor-associated protein, pseudogene 2 Neighboring gene MAX dimerization protein MGA Neighboring gene phospholipase A2 group IVB Neighboring gene jumonji domain containing 7 Neighboring gene spectrin, beta, non-erythrocytic 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process. Lecat A, et al. J Biol Chem, 2012 Aug 24. PMID 22700971, Free PMC Article
    2. Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis. Macia MS, et al. Am J Hum Genet, 2017 Feb 2. PMID 28089251, Free PMC Article
    3. A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1. Koyano S, et al. FEBS Lett, 1999 Sep 3. PMID 10471813
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108589.2 → NP_001102059.1  mitogen-activated protein kinase-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001102059.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ADP4, A6HPH9
      Related
      ENSRNOP00000009430.6, ENSRNOT00000009430.8
      Conserved Domains (3) summary
      COG2319
      Location:244 → 736
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:485 → 520
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:350 → 732
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001434329.1 → NP_001421258.1  mitogen-activated protein kinase-binding protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127401612..127452152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234781.5 → XP_006234843.1  mitogen-activated protein kinase-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZPD2, D3ZSY0
      Conserved Domains (3) summary
      COG2319
      Location:229 → 730
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:479 → 514
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:344 → 726
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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