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    MXR1 peptide-methionine-S-sulfoxide reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856765, updated on 9-Dec-2024

    Summary

    Official Symbol
    MXR1
    Official Full Name
    peptide-methionine-S-sulfoxide reductase
    Primary source
    SGD:S000000844
    Locus tag
    YER042W
    See related
    AllianceGenome:SGD:S000000844; FungiDB:YER042W; VEuPathDB:YER042W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables peptide-methionine (S)-S-oxide reductase activity. Involved in cellular response to oxidative stress. Located in cytoplasm. Orthologous to human MSRA (methionine sulfoxide reductase A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See MXR1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (234937..235491)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene nitrogen-responsive transcriptional regulator GLN3 Neighboring gene crossover junction endodeoxyribonuclease Neighboring gene adenosylhomocysteinase Neighboring gene Erg28p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    peptide-methionine-S-sulfoxide reductase
    NP_010960.1
    • Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      234937..235491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178933.1 → NP_010960.1  TPA: peptide-methionine-S-sulfoxide reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010960.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLU2, P40029
      UniProtKB/TrEMBL
      A6ZQZ1, B3LS55, C7GSI9, C8Z745, G2WCS5, N1PA37
      Conserved Domains (1) summary
      TIGR00401
      Location:17 → 171
      msrA; methionine-S-sulfoxide reductase
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