NCOA6 nuclear receptor coactivator 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NCOA6provided by HGNC
Official Full Name: nuclear receptor coactivator 6provided by HGNC
Primary source: HGNC:HGNC:15936
See related: Ensembl:ENSG00000198646 MIM:605299; AllianceGenome:HGNC:15936
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NRC; AIB3; ASC2; PRIP; TRBP; RAP250
Summary: The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Expression: Ubiquitous expression in testis (RPKM 8.8), thyroid (RPKM 7.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.22

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (34714774..34825651, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (36435437..36546294, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (33302578..33413454, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis.
Title: Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis.
Multiomics analyses and machine learning of nuclear receptor coactivator 6 reveal its essential role in hepatocellular carcinoma.
Title: Multiomics analyses and machine learning of nuclear receptor coactivator 6 reveal its essential role in hepatocellular carcinoma.
Nuclear receptor coactivator-6 is essential for the morphological change of human uterine stromal cell decidualization via regulating actin fiber reorganization.
Title: Nuclear receptor coactivator-6 is essential for the morphological change of human uterine stromal cell decidualization via regulating actin fiber reorganization.
Application of WES Towards Molecular Investigation of Congenital Cataracts: Identification of Novel Alleles and Genes in a Hospital-Based Cohort of South India.
Title: Application of WES Towards Molecular Investigation of Congenital Cataracts: Identification of Novel Alleles and Genes in a Hospital-Based Cohort of South India.
Nuclear receptor coactivator 6 promotes HTR-8/SVneo cell invasion and migration by activating NF-kappaB-mediated MMP9 transcription.
Title: Nuclear receptor coactivator 6 promotes HTR-8/SVneo cell invasion and migration by activating NF-κB-mediated MMP9 transcription.
NCOA6 associates with the GREB1 promoter and enhancer in an E2-independent manner and that NCOA6 knockout reduces chromatin looping, enhancer-promoter interactions, and basal GREB1 expression in the absence of estradiol.
Title: The transcriptional co-activator NCOA6 promotes estrogen-induced GREB1 transcription by recruiting ERα and enhancing enhancer-promoter interactions.
The retinoid x receptor does not interact with the NR box-1 of ASC-2, but functions as an allosteric activator of LXR binding to NR box-2 of ASC-2.
Title: RXR heterodimerization allosterically activates LXR binding to the second NR box of activating signal co-integrator-2.
diverse physiological function of NCOA6 may be mediated by multiple isoforms expressed in different tissues and localized in different subcellular compartments
Title: Identification and characterization of the alternatively spliced nuclear receptor coactivator-6 isoforms.
NCOA6 is responsible for the synergistic activation of CYP2C9 by HNF4alpha and pregnane X receptor and NCOA6 differentially regulates CYP2C9 and CYP3A4 gene expression though both the genes are regulated by the same nuclear receptors.
Title: NCOA6 differentially regulates the expression of the CYP2C9 and CYP3A4 genes.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of nuclear receptor coactivator 6 (NCOA6) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A008I23 (e-PCR)
- UniSTS:63006

GDB:314031 (e-PCR)
- UniSTS:64556

RH78465 (e-PCR)
- UniSTS:74599

NCOA6_3104.2 (e-PCR)
- UniSTS:471680

G18125 (e-PCR)
- UniSTS:65459

RH25395 (e-PCR)
- UniSTS:81593

D20S712E (e-PCR)
- UniSTS:153808

1444 (e-PCR)
- UniSTS:21242

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	TAS Traceable Author Statement more info	PubMed
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear retinoid X receptor binding	TAS Traceable Author Statement more info	PubMed
enables nuclear thyroid hormone receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of MLL3/4 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
part_of histone methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: nuclear receptor coactivator 6

Names: NRC RAP250; PPAR-interacting protein; activating signal cointegrator-2; amplified in breast cancer protein 3; amplified in breast cancer-3 protein; cancer-amplified transcriptional coactivator ASC-2; nuclear receptor coactivator RAP250; nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor interacting protein; thyroid hormone receptor binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242539.2 → NP_001229468.1 nuclear receptor coactivator 6 isoform 2

See identical proteins and their annotated locations for NP_001229468.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon in the central coding region, compared to variant 3. The encoded isoform (2, also known as NCOA6-beta) is shorter than isoform 1.

Source sequence(s)

AF208227, AI498955, AL109824, BC069829, JF707637

Consensus CDS

CCDS74720.1

UniProtKB/TrEMBL

F6M2K2, F6M2K4

Conserved Domains (2) summary

pfam09606
Location:392 → 803

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
NM_001318240.1 → NP_001305169.1 nuclear receptor coactivator 6 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1, also known as NCOA6-alpha). Variants 1 and 3 encode the same isoform.

Source sequence(s)

AF208227, AL049709, AL109824

Consensus CDS

CCDS13241.1

UniProtKB/Swiss-Prot

A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86

Related

ENSP00000363929.2, ENST00000374796.6

Conserved Domains (2) summary

pfam09606
Location:392 → 803

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
NM_014071.5 → NP_054790.2 nuclear receptor coactivator 6 isoform 1

See identical proteins and their annotated locations for NP_054790.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 encode the same isoform (1, also known as NCOA6-alpha).

Source sequence(s)

AI498955, AL049709, AL109824, BC069829, CR749037

Consensus CDS

CCDS13241.1

UniProtKB/Swiss-Prot

A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86

Related

ENSP00000351894.2, ENST00000359003.7

Conserved Domains (2) summary

pfam09606
Location:392 → 803

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

34714774..34825651 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047440068.1 → XP_047296024.1 nuclear receptor coactivator 6 isoform X33
XM_047440055.1 → XP_047296011.1 nuclear receptor coactivator 6 isoform X15
XM_017027744.3 → XP_016883233.1 nuclear receptor coactivator 6 isoform X13
XM_047440067.1 → XP_047296023.1 nuclear receptor coactivator 6 isoform X32
XM_047440059.1 → XP_047296015.1 nuclear receptor coactivator 6 isoform X19
XM_047440054.1 → XP_047296010.1 nuclear receptor coactivator 6 isoform X14
XM_047440052.1 → XP_047296008.1 nuclear receptor coactivator 6 isoform X12
XM_047440064.1 → XP_047296020.1 nuclear receptor coactivator 6 isoform X29

Related

ENSP00000481935.1, ENST00000616167.1
XM_017027751.2 → XP_016883240.1 nuclear receptor coactivator 6 isoform X28

UniProtKB/TrEMBL

F6M2K2, F6M2K4

Related

ENSP00000481177.1, ENST00000612493.4

Conserved Domains (2) summary

pfam09606
Location:392 → 803

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_047440057.1 → XP_047296013.1 nuclear receptor coactivator 6 isoform X17
XM_047440050.1 → XP_047296006.1 nuclear receptor coactivator 6 isoform X7
XM_017027742.3 → XP_016883231.1 nuclear receptor coactivator 6 isoform X3
XM_047440066.1 → XP_047296022.1 nuclear receptor coactivator 6 isoform X31
XM_011528727.4 → XP_011527029.1 nuclear receptor coactivator 6 isoform X10

Conserved Domains (2) summary

pfam09606
Location:427 → 855

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 195

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_047440065.1 → XP_047296021.1 nuclear receptor coactivator 6 isoform X30
XM_047440058.1 → XP_047296014.1 nuclear receptor coactivator 6 isoform X18
XM_047440051.1 → XP_047296007.1 nuclear receptor coactivator 6 isoform X11
XM_011528726.4 → XP_011527028.1 nuclear receptor coactivator 6 isoform X9

Conserved Domains (2) summary

pfam09606
Location:427 → 856

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 195

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_047440063.1 → XP_047296019.1 nuclear receptor coactivator 6 isoform X27
XM_047440056.1 → XP_047296012.1 nuclear receptor coactivator 6 isoform X16
XM_047440048.1 → XP_047296004.1 nuclear receptor coactivator 6 isoform X5
XM_011528721.4 → XP_011527023.1 nuclear receptor coactivator 6 isoform X4

See identical proteins and their annotated locations for XP_011527023.1

Conserved Domains (2) summary

pfam09606
Location:427 → 867

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 195

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_047440061.1 → XP_047296017.1 nuclear receptor coactivator 6 isoform X25
XM_017027750.3 → XP_016883239.1 nuclear receptor coactivator 6 isoform X24

UniProtKB/TrEMBL

F6M2K4
XM_017027748.2 → XP_016883237.1 nuclear receptor coactivator 6 isoform X23
XM_017027743.3 → XP_016883232.1 nuclear receptor coactivator 6 isoform X8
XM_017027741.2 → XP_016883230.1 nuclear receptor coactivator 6 isoform X2
XM_017027739.2 → XP_016883228.1 nuclear receptor coactivator 6 isoform X1
XM_047440053.1 → XP_047296009.1 nuclear receptor coactivator 6 isoform X13
XM_047440049.1 → XP_047296005.1 nuclear receptor coactivator 6 isoform X6

UniProtKB/Swiss-Prot

A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86
XM_047440047.1 → XP_047296003.1 nuclear receptor coactivator 6 isoform X1
XM_047440062.1 → XP_047296018.1 nuclear receptor coactivator 6 isoform X26
XM_047440060.1 → XP_047296016.1 nuclear receptor coactivator 6 isoform X22
XM_006723755.4 → XP_006723818.1 nuclear receptor coactivator 6 isoform X21

See identical proteins and their annotated locations for XP_006723818.1

UniProtKB/TrEMBL

F6M2K3

Conserved Domains (2) summary

pfam09606
Location:392 → 803

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_017027746.2 → XP_016883235.1 nuclear receptor coactivator 6 isoform X20

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

36435437..36546294 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054323279.1 → XP_054179254.1 nuclear receptor coactivator 6 isoform X33
XM_054323261.1 → XP_054179236.1 nuclear receptor coactivator 6 isoform X15
XM_054323258.1 → XP_054179233.1 nuclear receptor coactivator 6 isoform X13
XM_054323278.1 → XP_054179253.1 nuclear receptor coactivator 6 isoform X32
XM_054323265.1 → XP_054179240.1 nuclear receptor coactivator 6 isoform X19
XM_054323260.1 → XP_054179235.1 nuclear receptor coactivator 6 isoform X14
XM_054323257.1 → XP_054179232.1 nuclear receptor coactivator 6 isoform X12
XM_054323275.1 → XP_054179250.1 nuclear receptor coactivator 6 isoform X29
XM_054323274.1 → XP_054179249.1 nuclear receptor coactivator 6 isoform X28

UniProtKB/TrEMBL

F6M2K2
XM_054323263.1 → XP_054179238.1 nuclear receptor coactivator 6 isoform X17
XM_054323252.1 → XP_054179227.1 nuclear receptor coactivator 6 isoform X7
XM_054323248.1 → XP_054179223.1 nuclear receptor coactivator 6 isoform X3
XM_054323277.1 → XP_054179252.1 nuclear receptor coactivator 6 isoform X31
XM_054323255.1 → XP_054179230.1 nuclear receptor coactivator 6 isoform X10
XM_054323276.1 → XP_054179251.1 nuclear receptor coactivator 6 isoform X30
XM_054323264.1 → XP_054179239.1 nuclear receptor coactivator 6 isoform X18
XM_054323256.1 → XP_054179231.1 nuclear receptor coactivator 6 isoform X11
XM_054323254.1 → XP_054179229.1 nuclear receptor coactivator 6 isoform X9
XM_054323273.1 → XP_054179248.1 nuclear receptor coactivator 6 isoform X27
XM_054323262.1 → XP_054179237.1 nuclear receptor coactivator 6 isoform X16
XM_054323250.1 → XP_054179225.1 nuclear receptor coactivator 6 isoform X5
XM_054323249.1 → XP_054179224.1 nuclear receptor coactivator 6 isoform X4
XM_054323271.1 → XP_054179246.1 nuclear receptor coactivator 6 isoform X25
XM_054323270.1 → XP_054179245.1 nuclear receptor coactivator 6 isoform X24
XM_054323269.1 → XP_054179244.1 nuclear receptor coactivator 6 isoform X23
XM_054323253.1 → XP_054179228.1 nuclear receptor coactivator 6 isoform X8
XM_054323247.1 → XP_054179222.1 nuclear receptor coactivator 6 isoform X2
XM_054323245.1 → XP_054179220.1 nuclear receptor coactivator 6 isoform X1
XM_054323259.1 → XP_054179234.1 nuclear receptor coactivator 6 isoform X13
XM_054323251.1 → XP_054179226.1 nuclear receptor coactivator 6 isoform X6

UniProtKB/Swiss-Prot

A6NLF1, B2RMN5, E1P5P7, Q14686, Q9NTZ9, Q9UH74, Q9UK86
XM_054323246.1 → XP_054179221.1 nuclear receptor coactivator 6 isoform X1
XM_054323272.1 → XP_054179247.1 nuclear receptor coactivator 6 isoform X26
XM_054323268.1 → XP_054179243.1 nuclear receptor coactivator 6 isoform X22
XM_054323267.1 → XP_054179242.1 nuclear receptor coactivator 6 isoform X21

UniProtKB/TrEMBL

F6M2K3
XM_054323266.1 → XP_054179241.1 nuclear receptor coactivator 6 isoform X20