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    T23B5.4 Prokaryotic-type class I peptide chain release factors domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565854, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T23B5.4
    Official Full Name
    Prokaryotic-type class I peptide chain release factors domain-containing protein
    Primary source
    WormBase:WBGene00011941
    Locus tag
    CELE_T23B5.4
    See related
    AllianceGenome:WB:WBGene00011941
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation release factor activity. Predicted to be involved in translational termination. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 7 and hereditary spastic paraplegia 55. Orthologous to human MTRFR (mitochondrial translation release factor in rescue). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T23B5.4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (12675000..12676004)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene WD repeat and FYVE domain-containing protein 3 Neighboring gene ncRNA Neighboring gene Transcriptional regulator Neighboring gene PRotein arginine MethylTransferase Neighboring gene C3H1-type domain-containing protein;Coiled-coil domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables translation release factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Prokaryotic-type class I peptide chain release factors domain-containing protein
    NP_001255660.1
    • Partially confirmed by transcript evidence
    NP_001255661.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12675000..12676004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268731.3 → NP_001255660.1  Prokaryotic-type class I peptide chain release factors domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255660.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E5QCJ3
      Conserved Domains (1) summary
      pfam00472
      Location:57 → 133
      RF-1; RF-1 domain

    2. NM_001268732.4 → NP_001255661.1  Prokaryotic-type class I peptide chain release factors domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YWT5
      Conserved Domains (1) summary
      pfam00472
      Location:41 → 117
      RF-1; RF-1 domain
    Nucleotide Protein
    Heading Accession and Version

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