U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Orc4 origin recognition complex, subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 26428, updated on 3-Dec-2024

    Summary

    Official Symbol
    Orc4provided by MGI
    Official Full Name
    origin recognition complex, subunit 4provided by MGI
    Primary source
    MGI:MGI:1347043
    See related
    Ensembl:ENSMUSG00000026761 AllianceGenome:MGI:1347043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Orc4P; Orc4l; mMmORC4
    Summary
    Predicted to enable DNA replication origin binding activity and nucleotide binding activity. Involved in polar body extrusion after meiotic divisions and protein polymerization. Acts upstream of or within DNA replication. Is active in cytoplasm. Is expressed in brain; embryo; and pancreas epithelium. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 9.0), CNS E14 (RPKM 7.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Orc4 in Genome Data Viewer
    Location:
    2 C1.1; 2 28.42 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (48792836..48840287, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (48902824..48952902, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31324 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene activin receptor IIA Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:48804892-48805001 Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene predicted gene 13510 Neighboring gene adaptor-related protein complex 2, mu 1 subunit, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA replication origin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear origin of replication recognition complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nuclear origin of replication recognition complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    origin recognition complex subunit 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177313.2NP_001170784.1  origin recognition complex subunit 4 isoform 2

      See identical proteins and their annotated locations for NP_001170784.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons, but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1. Variants 2, 11, 12, and 13 all encode the same isoform (2).
      Source sequence(s)
      AL732317, AL845521
      Consensus CDS
      CCDS50582.1
      UniProtKB/TrEMBL
      Q9CZF7
      Related
      ENSMUSP00000088497.4, ENSMUST00000090976.10
      Conserved Domains (2) summary
      PRK00411
      Location:46130
      cdc6; ORC1-type DNA replication protein
      pfam13191
      Location:3582
      AAA_16; AAA ATPase domain
    2. NM_001355296.2NP_001342225.1  origin recognition complex subunit 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4, 7, and 8 all encode the same isoform (1).
      Source sequence(s)
      AL732317, AL845521
      Consensus CDS
      CCDS16022.1
      UniProtKB/Swiss-Prot
      O88708, Q91V62, Q9QYX1
      UniProtKB/TrEMBL
      Q8BN98, Q8C693
      Conserved Domains (2) summary
      COG1474
      Location:41223
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:225412
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
    3. NM_001421264.1NP_001408193.1  origin recognition complex subunit 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
      UniProtKB/Swiss-Prot
      O88708, Q91V62, Q9QYX1
      UniProtKB/TrEMBL
      Q8BN98, Q8C693
    4. NM_001421265.1NP_001408194.1  origin recognition complex subunit 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
      UniProtKB/Swiss-Prot
      O88708, Q91V62, Q9QYX1
      UniProtKB/TrEMBL
      Q8BN98, Q8C693
    5. NM_001421266.1NP_001408195.1  origin recognition complex subunit 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
      UniProtKB/TrEMBL
      Q8BN98, Q8C693
    6. NM_001421267.1NP_001408196.1  origin recognition complex subunit 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
      UniProtKB/TrEMBL
      Q8BTB0
      Related
      ENSMUSP00000119274.2, ENSMUST00000142851.8
    7. NM_001421268.1NP_001408197.1  origin recognition complex subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
      UniProtKB/TrEMBL
      Q9CZF7
    8. NM_001421269.1NP_001408198.1  origin recognition complex subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
      UniProtKB/TrEMBL
      Q9CZF7
    9. NM_001421270.1NP_001408199.1  origin recognition complex subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
      UniProtKB/TrEMBL
      Q9CZF7
    10. NM_011958.5NP_036088.3  origin recognition complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_036088.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, 7, and 8 all encode the same isoform (1).
      Source sequence(s)
      AL732317, AL845521
      Consensus CDS
      CCDS16022.1
      UniProtKB/Swiss-Prot
      O88708, Q91V62, Q9QYX1
      UniProtKB/TrEMBL
      Q8BN98, Q8C693
      Related
      ENSMUSP00000028098.5, ENSMUST00000028098.11
      Conserved Domains (2) summary
      COG1474
      Location:41223
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:225412
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

    RNA

    1. NR_033442.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment in the 3' CDS, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate and is probably not making a protein.
      Source sequence(s)
      AL732317, AL845521
    2. NR_149355.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
    3. NR_149356.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
    4. NR_185286.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
    5. NR_185287.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
      Related
      ENSMUST00000154784.8
    6. NR_185288.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521
    7. NR_185289.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732317, AL845521

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      48792836..48840287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498066.4XP_006498129.1  origin recognition complex subunit 4 isoform X2

      UniProtKB/TrEMBL
      Q8BN98, Q8C693
      Conserved Domains (2) summary
      COG1474
      Location:41190
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:195354
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
    2. XM_030251581.1XP_030107441.1  origin recognition complex subunit 4 isoform X2

      UniProtKB/TrEMBL
      Q8BN98, Q8C693
      Conserved Domains (2) summary
      COG1474
      Location:41190
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:195354
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus