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    Dpp8 dipeptidylpeptidase 8 [ Mus musculus (house mouse) ]

    Gene ID: 74388, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dpp8provided by MGI
    Official Full Name
    dipeptidylpeptidase 8provided by MGI
    Primary source
    MGI:MGI:1921638
    See related
    Ensembl:ENSMUSG00000032393 AllianceGenome:MGI:1921638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DP8; DPP VIII; 2310004I03Rik; 4932434F09Rik
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; immune system; limb mesenchyme; metanephros; and skin. Orthologous to human DPP8 (dipeptidyl peptidase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 15.6), cerebellum adult (RPKM 15.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dpp8 in Genome Data Viewer
    Location:
    9 C; 9 35.06 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64939688..64991785)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65032406..65084503)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene STARR-positive B cell enhancer ABC_E9330 Neighboring gene predicted gene, 39362 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24441 Neighboring gene immunoglobulin superfamily, DCC subclass, member 4 Neighboring gene immunoglobulin superfamily, DCC subclass, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dipeptidyl-peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dipeptidyl peptidase 8
    Names
    dipeptidyl peptidase VIII
    NP_001388065.1
    NP_083182.2
    XP_006511580.1
    XP_030100547.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401136.1NP_001388065.1  dipeptidyl peptidase 8

      Status: VALIDATED

      Source sequence(s)
      AC122463
      UniProtKB/Swiss-Prot
      Q80YA7, Q9D4G6
      Related
      ENSMUSP00000126065.2, ENSMUST00000167773.2
    2. NM_028906.3NP_083182.2  dipeptidyl peptidase 8

      See identical proteins and their annotated locations for NP_083182.2

      Status: VALIDATED

      Source sequence(s)
      AC122463
      Consensus CDS
      CCDS23285.1
      UniProtKB/Swiss-Prot
      Q80YA7, Q9D4G6
      Related
      ENSMUSP00000034960.7, ENSMUST00000034960.14
      Conserved Domains (2) summary
      pfam00326
      Location:680885
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:169589
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64939688..64991785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511517.5XP_006511580.1  dipeptidyl peptidase 8 isoform X2

      Conserved Domains (2) summary
      pfam00326
      Location:671876
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:160579
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    2. XM_030244687.2XP_030100547.1  dipeptidyl peptidase 8 isoform X3

      Conserved Domains (2) summary
      pfam00326
      Location:267472
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:11175
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RNA

    1. XR_003948041.2 RNA Sequence