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    ZNF843 zinc finger protein 843 [ Homo sapiens (human) ]

    Gene ID: 283933, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF843provided by HGNC
    Official Full Name
    zinc finger protein 843provided by HGNC
    Primary source
    HGNC:HGNC:28710
    See related
    Ensembl:ENSG00000176723 AllianceGenome:HGNC:28710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See ZNF843 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (31435434..31443160, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31822848..31830569, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31446755..31454481, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha D Neighboring gene cytochrome c oxidase subunit 6A2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31446802-31447302 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:31447884-31448054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31453737-31454532 Neighboring gene Sharpr-MPRA regulatory region 15326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31464004-31464776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31464777-31465548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31468736-31469304 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:31469952-31470492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7419 Neighboring gene armadillo repeat containing 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31483812-31484352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:31486867-31487599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31487600-31488331 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:31488332-31489064 Neighboring gene transforming growth factor beta 1 induced transcript 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Taipale M, et al. Cell, 2014 Jul 17. PMID 25036637, Free PMC Article
    2. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Taipale M, et al. Cell, 2012 Aug 31. PMID 22939624, Free PMC Article
    3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46336

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 843

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136509.3 → NP_001129981.1  zinc finger protein 843

      See identical proteins and their annotated locations for NP_001129981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC026471, AK096248, AK291063, BC036762
      Consensus CDS
      CCDS45471.1
      UniProtKB/Swiss-Prot
      A8K4U8, Q8N446
      Related
      ENSP00000322899.5, ENST00000315678.10
      Conserved Domains (2) summary
      sd00017
      Location:35 → 55
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl26464
      Location:163 → 334
      Atrophin-1; Atrophin-1 family

    2. NM_001353381.1 → NP_001340310.1  zinc finger protein 843

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to isoform 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC036762
      Consensus CDS
      CCDS45471.1
      UniProtKB/Swiss-Prot
      A8K4U8, Q8N446
      Related
      ENSP00000483573.1, ENST00000618063.1
      Conserved Domains (2) summary
      sd00017
      Location:35 → 55
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl26464
      Location:163 → 334
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      31435434..31443160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      31822848..31830569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N446.1 GenPept UniProtKB/Swiss-Prot:Q8N446

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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