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    Sec24CD Secretory 24CD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec24CDprovided by FlyBase
    Official Full Name
    Secretory 24CDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262126
    Locus tag
    Dmel_CG10882
    See related
    AllianceGenome:FB:FBgn0262126
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP05220; CG10882; Dmel\CG10882; FBgn0031408; gho; Gho; sec24; Sec24; sfb3; sten; Sten
    Summary
    Predicted to enable SNARE binding activity and zinc ion binding activity. Involved in several processes, including protein localization to cell surface; regulation of tube diameter, open tracheal system; and secretion by cell. Acts upstream of with a positive effect on chitin-based cuticle development and lumen formation, open tracheal system. Located in endoplasmic reticulum exit site. Part of COPII vesicle coat. Is expressed in several structures, including circulatory system primordium; embryonic/larval midgut primordium; epithelium; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to several human genes including SEC24D (SEC24 homolog D, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sec24CD in Genome Data Viewer
    Location:
    22D4-22D5; 2-5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2231106..2236844, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2231106..2236844, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44114 Neighboring gene sauron Neighboring gene antisense RNA:CR44115 Neighboring gene Testis EndoG-Like 3 Neighboring gene Testis EndoG-Like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Conserved Di-Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export. Kumichel A, et al. Traffic, 2015 Jun. PMID 25753515, Free PMC Article
    2. Cut, via CrebA, transcriptionally regulates the COPII secretory pathway to direct dendrite development in Drosophila. Iyer SC, et al. J Cell Sci, 2013 Oct 15. PMID 23902691, Free PMC Article
    3. The apical plasma membrane of chitin-synthesizing epithelia. Moussian B. Insect Sci, 2013 Apr. PMID 23955854
    4. Drosophila Embryos as a Model for Wound-Induced Transcriptional Dynamics: Genetic Strategies to Achieve a Localized Wound Response. Juarez MT. Adv Wound Care (New Rochelle), 2016 Jun 1. PMID 27274436, Free PMC Article
    5. Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation. Norum M, et al. PLoS One, 2010 May 24. PMID 20520821, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII-coated vesicle cargo loading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_positive_effect chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix constituent secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_positive_effect lumen formation, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube diameter, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPII vesicle coat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of COPII vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretory 24CD
    Names
    CG10882-PA
    CG10882-PB
    CG10882-PC
    Sec24CD ortholog
    Sec24CD-PA
    Sec24CD-PB
    Sec24CD-PC
    ghost
    stenosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2231106..2236844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272988.1 → NP_001259917.1  secretory 24CD, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259917.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960I6, Q9VQ94
      Conserved Domains (6) summary
      COG5028
      Location:395 → 1190
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:599 → 847
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:1061 → 1135
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:522 → 559
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:950 → 1043
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:848 → 932
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    2. NM_001272989.1 → NP_001259918.1  secretory 24CD, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC99
      Conserved Domains (6) summary
      COG5028
      Location:395 → 1190
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:599 → 847
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:1061 → 1135
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:522 → 559
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:950 → 1043
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:848 → 932
      Sec23_BS; Sec23/Sec24 beta-sandwich domain

    3. NM_134820.3 → NP_608664.2  secretory 24CD, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608664.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960I6, Q9VQ94
      Related
      FBpp0077487
      Conserved Domains (6) summary
      COG5028
      Location:395 → 1190
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:599 → 847
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:1061 → 1135
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:522 → 559
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:950 → 1043
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:848 → 932
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC99 M9PC99
    Q9VQ94 Q9VQ94

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