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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_027748.2 RefSeqGene
- Range
-
5002..86077
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001130438.3 → NP_001123910.1 spectrin alpha chain, non-erythrocytic 1 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
AL356481
- Consensus CDS
-
CCDS48036.1
- UniProtKB/TrEMBL
-
A0A994J4G5
- Related
- ENSP00000361824.4, ENST00000372739.7
- Conserved Domains (5) summary
-
- cd11808
Location:971 → 1023
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2332 → 2400
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:679 → 890
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam08726
Location:2407 → 2475
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam00435
Location:1663 → 1765
- Spectrin; Spectrin repeat
-
NM_001195532.2 → NP_001182461.1 spectrin alpha chain, non-erythrocytic 1 isoform 3
See identical proteins and their annotated locations for NP_001182461.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
- Source sequence(s)
-
AL356481
- Consensus CDS
-
CCDS75914.1
- UniProtKB/TrEMBL
- A0A384P5S9, A0A994J4G5
- Related
- ENSP00000350882.6, ENST00000358161.9
- Conserved Domains (5) summary
-
- cd11808
Location:971 → 1023
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2307 → 2375
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:679 → 890
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam00435
Location:1638 → 1742
- Spectrin; Spectrin repeat
- pfam08726
Location:2382 → 2450
- EFhand_Ca_insen; Ca2+ insensitive EF hand
-
NM_001363759.2 → NP_001350688.1 spectrin alpha chain, non-erythrocytic 1 isoform 4
Status: REVIEWED
- Source sequence(s)
-
AL356481
- Consensus CDS
-
CCDS87695.1
- UniProtKB/TrEMBL
- A0A0D9SGF6, A0A994J4G5
- Related
- ENSP00000487444.1, ENST00000630866.2
- Conserved Domains (5) summary
-
- cd11808
Location:971 → 1023
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2353 → 2421
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:679 → 890
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam00435
Location:1663 → 1767
- Spectrin; Spectrin repeat
- pfam08726
Location:2428 → 2496
- EFhand_Ca_insen; Ca2+ insensitive EF hand
-
NM_001363765.2 → NP_001350694.1 spectrin alpha chain, non-erythrocytic 1 isoform 5
Status: REVIEWED
- Source sequence(s)
-
AL356481
- Consensus CDS
-
CCDS87696.1
- UniProtKB/TrEMBL
- A0A0D9SF54, A0A994J4G5
- Related
- ENSP00000486308.1, ENST00000630804.2
- Conserved Domains (5) summary
-
- cd11808
Location:971 → 1023
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2312 → 2380
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:679 → 890
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam08726
Location:2387 → 2455
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam00435
Location:1643 → 1745
- Spectrin; Spectrin repeat
-
NM_001375310.1 → NP_001362239.1 spectrin alpha chain, non-erythrocytic 1 isoform 6
Status: REVIEWED
- Source sequence(s)
-
AL356481
- Consensus CDS
-
CCDS94501.1
- UniProtKB/TrEMBL
- A0A994J4G5, A0A994J6W3
- Related
- ENSP00000515764.1, ENST00000704202.1
- Conserved Domains (5) summary
-
- cd11808
Location:971 → 1023
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2361 → 2429
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:679 → 890
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam08726
Location:2436 → 2504
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam00435
Location:1663 → 1765
- Spectrin; Spectrin repeat
-
NM_001375311.2 → NP_001362240.1 spectrin alpha chain, non-erythrocytic 1 isoform 1
Status: REVIEWED
- Source sequence(s)
-
AL356481
- Consensus CDS
-
CCDS48036.1
- UniProtKB/TrEMBL
-
A0A994J4G5
- Related
- ENSP00000516412.1, ENST00000706487.1
- Conserved Domains (5) summary
-
- cd11808
Location:971 → 1023
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2332 → 2400
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:679 → 890
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam08726
Location:2407 → 2475
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam00435
Location:1663 → 1765
- Spectrin; Spectrin repeat
-
NM_001375312.2 → NP_001362241.2 spectrin alpha chain, non-erythrocytic 1 isoform 8
Status: REVIEWED
- Source sequence(s)
-
AL356481
- Consensus CDS
-
CCDS94500.1
- UniProtKB/TrEMBL
- A0A0D9SFF6, A0A994J4G5
- Related
- ENSP00000515765.1, ENST00000704203.1
- Conserved Domains (5) summary
-
- cd11808
Location:983 → 1035
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2344 → 2412
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:691 → 902
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam08726
Location:2419 → 2487
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam00435
Location:1675 → 1777
- Spectrin; Spectrin repeat
-
NM_001375313.1 → NP_001362242.1 spectrin alpha chain, non-erythrocytic 1 isoform 7
Status: REVIEWED
- Source sequence(s)
-
AL356481
- UniProtKB/TrEMBL
-
A0A994J4G5
- Conserved Domains (5) summary
-
- cd11808
Location:971 → 1023
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2326 → 2394
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:679 → 890
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam08726
Location:2401 → 2469
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam00435
Location:1663 → 1765
- Spectrin; Spectrin repeat
-
NM_001375314.2 → NP_001362243.1 spectrin alpha chain, non-erythrocytic 1 isoform 5
Status: REVIEWED
- Source sequence(s)
-
AL356481
- Consensus CDS
-
CCDS87696.1
- UniProtKB/TrEMBL
- A0A0D9SF54, A0A994J4G5
- Conserved Domains (5) summary
-
- cd11808
Location:971 → 1023
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2312 → 2380
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:679 → 890
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam08726
Location:2387 → 2455
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam00435
Location:1643 → 1745
- Spectrin; Spectrin repeat
-
NM_001375318.1 → NP_001362247.1 spectrin alpha chain, non-erythrocytic 1 isoform 9
Status: REVIEWED
- Source sequence(s)
-
AL356481
- UniProtKB/TrEMBL
-
A0A994J4G5
- Conserved Domains (5) summary
-
- cd11808
Location:983 → 1035
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2365 → 2433
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:691 → 902
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam08726
Location:2440 → 2508
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam00435
Location:1675 → 1777
- Spectrin; Spectrin repeat
-
NM_003127.4 → NP_003118.2 spectrin alpha chain, non-erythrocytic 1 isoform 2
See identical proteins and their annotated locations for NP_003118.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
- Source sequence(s)
-
AL356481
- Consensus CDS
-
CCDS6905.1
- UniProtKB/Swiss-Prot
- Q13186, Q13813, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0
- UniProtKB/TrEMBL
-
A0A994J4G5
- Related
- ENSP00000361816.4, ENST00000372731.8
- Conserved Domains (6) summary
-
- cd11808
Location:971 → 1023
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2327 → 2395
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:679 → 890
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam00435
Location:1658 → 1762
- Spectrin; Spectrin repeat
- pfam08726
Location:2402 → 2470
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam13499
Location:2330 → 2395
- EF-hand_7; EF-hand domain pair
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000009.12 Reference GRCh38.p14 Primary Assembly
- Range
-
128552587..128633662
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047423783.1 → XP_047279739.1 spectrin alpha chain, non-erythrocytic 1 isoform X1
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423787.1 → XP_047279743.1 spectrin alpha chain, non-erythrocytic 1 isoform X5
- UniProtKB/TrEMBL
- A0A0D9SFF6, A0A994J4G5
- Related
- ENSP00000486547.2, ENST00000627441.3
-
XM_047423790.1 → XP_047279746.1 spectrin alpha chain, non-erythrocytic 1 isoform X8
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423784.1 → XP_047279740.1 spectrin alpha chain, non-erythrocytic 1 isoform X2
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423789.1 → XP_047279745.1 spectrin alpha chain, non-erythrocytic 1 isoform X7
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423791.1 → XP_047279747.1 spectrin alpha chain, non-erythrocytic 1 isoform X9
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423786.1 → XP_047279742.1 spectrin alpha chain, non-erythrocytic 1 isoform X4
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423794.1 → XP_047279750.1 spectrin alpha chain, non-erythrocytic 1 isoform X12
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_017015060.2 → XP_016870549.1 spectrin alpha chain, non-erythrocytic 1 isoform X15
- UniProtKB/TrEMBL
-
A0A994J4G5
- Conserved Domains (5) summary
-
- PTZ00184
Location:2311 → 2460
- PTZ00184; calmodulin; Provisional
- smart00150
Location:1658 → 1758
- SPEC; Spectrin repeats
- cd11808
Location:983 → 1035
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2318 → 2386
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:691 → 902
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
-
XM_047423788.1 → XP_047279744.1 spectrin alpha chain, non-erythrocytic 1 isoform X6
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423796.1 → XP_047279752.1 spectrin alpha chain, non-erythrocytic 1 isoform X14
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423797.1 → XP_047279753.1 spectrin alpha chain, non-erythrocytic 1 isoform X16
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423785.1 → XP_047279741.1 spectrin alpha chain, non-erythrocytic 1 isoform X3
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423795.1 → XP_047279751.1 spectrin alpha chain, non-erythrocytic 1 isoform X13
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_006717251.3 → XP_006717314.1 spectrin alpha chain, non-erythrocytic 1 isoform X10
- UniProtKB/TrEMBL
-
A0A994J4G5
- Related
- ENSP00000515766.1, ENST00000704204.1
- Conserved Domains (6) summary
-
- cd11808
Location:971 → 1023
- SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
- cd00051
Location:2333 → 2401
- EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
- cd00176
Location:679 → 890
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
- pfam00435
Location:1643 → 1747
- Spectrin; Spectrin repeat
- pfam08726
Location:2408 → 2476
- EFhand_Ca_insen; Ca2+ insensitive EF hand
- pfam13499
Location:2336 → 2401
- EF-hand_7; EF-hand domain pair
-
XM_047423798.1 → XP_047279754.1 spectrin alpha chain, non-erythrocytic 1 isoform X17
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423793.1 → XP_047279749.1 spectrin alpha chain, non-erythrocytic 1 isoform X11
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_047423799.1 → XP_047279755.1 spectrin alpha chain, non-erythrocytic 1 isoform X18
- UniProtKB/TrEMBL
-
A0A994J4G5
Alternate T2T-CHM13v2.0
Genomic
-
NC_060933.1 Alternate T2T-CHM13v2.0
- Range
-
140759427..140840530
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054363628.1 → XP_054219603.1 spectrin alpha chain, non-erythrocytic 1 isoform X1
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363632.1 → XP_054219607.1 spectrin alpha chain, non-erythrocytic 1 isoform X5
- UniProtKB/TrEMBL
- A0A0D9SFF6, A0A994J4G5
-
XM_054363635.1 → XP_054219610.1 spectrin alpha chain, non-erythrocytic 1 isoform X8
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363629.1 → XP_054219604.1 spectrin alpha chain, non-erythrocytic 1 isoform X2
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363634.1 → XP_054219609.1 spectrin alpha chain, non-erythrocytic 1 isoform X7
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363636.1 → XP_054219611.1 spectrin alpha chain, non-erythrocytic 1 isoform X9
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363631.1 → XP_054219606.1 spectrin alpha chain, non-erythrocytic 1 isoform X4
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363639.1 → XP_054219614.1 spectrin alpha chain, non-erythrocytic 1 isoform X12
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363642.1 → XP_054219617.1 spectrin alpha chain, non-erythrocytic 1 isoform X15
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363633.1 → XP_054219608.1 spectrin alpha chain, non-erythrocytic 1 isoform X6
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363641.1 → XP_054219616.1 spectrin alpha chain, non-erythrocytic 1 isoform X14
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363643.1 → XP_054219618.1 spectrin alpha chain, non-erythrocytic 1 isoform X16
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363630.1 → XP_054219605.1 spectrin alpha chain, non-erythrocytic 1 isoform X3
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363640.1 → XP_054219615.1 spectrin alpha chain, non-erythrocytic 1 isoform X13
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363637.1 → XP_054219612.1 spectrin alpha chain, non-erythrocytic 1 isoform X10
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363644.1 → XP_054219619.1 spectrin alpha chain, non-erythrocytic 1 isoform X17
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363638.1 → XP_054219613.1 spectrin alpha chain, non-erythrocytic 1 isoform X11
- UniProtKB/TrEMBL
-
A0A994J4G5
-
XM_054363645.1 → XP_054219620.1 spectrin alpha chain, non-erythrocytic 1 isoform X18
- UniProtKB/TrEMBL
-
A0A994J4G5