EIF3A eukaryotic translation initiation factor 3 subunit A [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF3Aprovided by HGNC
Official Full Name: eukaryotic translation initiation factor 3 subunit Aprovided by HGNC
Primary source: HGNC:HGNC:3271
See related: Ensembl:ENSG00000107581 MIM:602039; AllianceGenome:HGNC:3271
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EIF3; P167; p180; p185; TIF32; EIF3S10; eIF3-p170; eIF3-theta
Summary: Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thyroid (RPKM 51.4), fat (RPKM 50.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.11

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (119033670..119080817, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (119929080..119976262, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (120793182..120840329, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
Title: The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content.
Title: eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content.
Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation.
Title: Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation.
YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.
Title: YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.
eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage.
Title: eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage.
eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
Title: eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells.
Title: Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells.
The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
Title: The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway.
Title: LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway.
MicroRNA8755p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
Title: MicroRNA‑875‑5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pol	gag-pol	HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

EST20A11 (e-PCR)
- UniSTS:263210

PMC156606P4 (e-PCR)
- UniSTS:271411

D8S2279 (e-PCR)
- UniSTS:473907

WI-14638 (e-PCR)
- UniSTS:63065

D10S16 (e-PCR)
- UniSTS:155756

D10S2416 (e-PCR)
- UniSTS:40349

EIF3S10 (e-PCR)
- UniSTS:502947

RH25362 (e-PCR)
- UniSTS:84674

RH11315 (e-PCR)
- UniSTS:89029

RH64952 (e-PCR)
- UniSTS:92101

EIF3S10_439 (e-PCR)
- UniSTS:277196

RH98964 (e-PCR)
- UniSTS:88793

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	NAS Non-traceable Author Statement more info	PubMed
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to translation initiation factor activity	IC Inferred by Curator more info	PubMed
contributes_to translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in IRES-dependent viral translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in formation of cytoplasmic translation initiation complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in formation of cytoplasmic translation initiation complex	IDA Inferred from Direct Assay more info	PubMed
involved_in formation of cytoplasmic translation initiation complex	NAS Non-traceable Author Statement more info	PubMed
involved_in translation reinitiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IC Inferred by Curator more info	PubMed
involved_in viral translational termination-reinitiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of eukaryotic translation initiation factor 3 complex, eIF3e	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	HDA more info	PubMed
part_of multi-eIF complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit A

Names: EIF3, p180 subunit; centrosomin homolog; cytoplasmic protein p167; eIF-3-theta; eIF3 p167; eIF3 p180; eIF3 p185; eukaryotic translation initiation factor 3 subunit 10; eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD); eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD); eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa; eukaryotic translation initiation factor 3, subunit 10, 170kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003750.4 → NP_003741.1 eukaryotic translation initiation factor 3 subunit A

See identical proteins and their annotated locations for NP_003741.1

Status: VALIDATED

Source sequence(s)

AL157788, AL355598

Consensus CDS

CCDS7608.1

UniProtKB/Swiss-Prot

B1AMV5, B4DYS1, F5H335, O00653, Q14152, Q15778

UniProtKB/TrEMBL

Q24JU4

Related

ENSP00000358140.3, ENST00000369144.8

Conserved Domains (5) summary

smart00088
Location:426 → 498

PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

COG1196
Location:517 → 791

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK12678
Location:910 → 1126

PRK12678; transcription termination factor Rho; Provisional

PRK14086
Location:1127 → 1253

dnaA; chromosomal replication initiator protein DnaA

TIGR01642
Location:1199 → 1258

U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor