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    UBXN2B UBX domain protein 2B [ Homo sapiens (human) ]

    Gene ID: 137886, updated on 10-Dec-2024

    Summary

    Official Symbol
    UBXN2Bprovided by HGNC
    Official Full Name
    UBX domain protein 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:27035
    See related
    Ensembl:ENSG00000215114 MIM:610686; AllianceGenome:HGNC:27035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p37
    Summary
    Predicted to enable ubiquitin binding activity. Involved in establishment of mitotic spindle orientation; negative regulation of protein localization to centrosome; and positive regulation of mitotic centrosome separation. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and spindle pole centrosome. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 9.6), thyroid (RPKM 8.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UBXN2B in Genome Data Viewer
    Location:
    8q12.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (58411361..58451501)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (58832480..58872635)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (59323920..59364060)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986945 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:59108481-59109680 Neighboring gene VISTA enhancer hs1364 Neighboring gene long intergenic non-protein coding RNA 3133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27407 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:59282662-59283206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:59304090-59304590 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:59304591-59305091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:59308925-59309426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:59309427-59309926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:59350272-59350772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:59350773-59351273 Neighboring gene PTPN11 pseudogene 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:59404317-59405516 Neighboring gene CYP7A1 5' regulatory region Neighboring gene cytochrome P450 family 7 subfamily A member 1 Neighboring gene peptidylprolyl isomerase A pseudogene 85

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (19 hits/1263 screens)

    EBI GWAS Catalog

    Description
    Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study.
    EBI GWAS Catalog

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables ubiquitin binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in cytosol  
    located_in endoplasmic reticulum  
    is_active_in nucleus  
    located_in spindle pole centrosome  

    General protein information

    Preferred Names
    UBX domain-containing protein 2B
    Names
    NSFL1 cofactor p37
    p97 cofactor p37

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077619.2 → NP_001071087.1  UBX domain-containing protein 2B isoform 1

      See identical proteins and their annotated locations for NP_001071087.1

      Status: VALIDATED

      Source sequence(s)
      AK126300, BC113645, U79282
      Consensus CDS
      CCDS43741.1
      UniProtKB/Swiss-Prot
      B3KWZ3, Q14CS0
      Related
      ENSP00000382507.2, ENST00000399598.7
      Conserved Domains (2) summary
      cd01770
      Location:253 → 331
      p47_UBX; p47-like ubiquitin domain
      smart00553
      Location:140 → 232
      SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
    2. NM_001330535.2 → NP_001317464.1  UBX domain-containing protein 2B isoform 2

      Status: VALIDATED

      Source sequence(s)
      BE502216, DA185219, DA242203
      Consensus CDS
      CCDS83297.1
      UniProtKB/TrEMBL
      E5RJ36
      Related
      ENSP00000428314.1, ENST00000523409.5
      Conserved Domains (1) summary
      cl02662
      Location:146 → 178
      SEP; SEP domain
    3. NM_001363181.1 → NP_001350110.1  UBX domain-containing protein 2B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK126300, BC113645, U79282
      Conserved Domains (2) summary
      cd01770
      Location:207 → 285
      p47_UBX; p47-like ubiquitin domain
      cl02662
      Location:146 → 182
      SEP; SEP domain

    RNA

    1. NR_156456.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK126300, BC113645, DB337840, U79282

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      58411361..58451501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      58832480..58872635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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