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    EOL2 ETO1-like 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835968, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EOL2
    Official Full Name
    ETO1-like 2
    Primary source
    TAIR:AT5G58550
    Locus tag
    AT5G58550
    See related
    Araport:AT5G58550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ETO1-like 2; MZN1.1
    Summary
    Encodes a paralog of ETO1, which is a negative regulator of ACS5 (a key enzyme in ethylene biosynthesis pathway). EOL2 also interacts with and inhibits the activity of ACS5.
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    Genomic context

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    See EOL2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (23665295..23668886, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Glutaredoxin family protein Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein Neighboring gene Phosphatidate cytidylyltransferase family protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ACC synthase and its cognate E3 ligase are inversely regulated by light. Yoon GM, et al. Plant Signal Behav, 2013. PMID 24065059, Free PMC Article
    2. Regulation of ethylene gas biosynthesis by the Arabidopsis ETO1 protein. Wang KL, et al. Nature, 2004 Apr 29. PMID 15118728
    3. The BTB ubiquitin ligases ETO1, EOL1 and EOL2 act collectively to regulate ethylene biosynthesis in Arabidopsis by controlling type-2 ACC synthase levels. Christians MJ, et al. Plant J, 2009 Jan. PMID 18808454, Free PMC Article
    4. 14-3-3 regulates 1-aminocyclopropane-1-carboxylate synthase protein turnover in Arabidopsis. Yoon GM, et al. Plant Cell, 2013 Mar. PMID 23512855, Free PMC Article
    5. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Treatment of etiolated Arabidopsis seedlings with light rapidly increases the stability of ACS5 protein and destabilizes the ETO1/EOLs proteins.
      Title: ACC synthase and its cognate E3 ligase are inversely regulated by light.
    2. ETO1, EOL1 and EOL2 work together to negatively regulate ethylene synthesis, by helping degrade type-2 ACC synthases.
      Title: The BTB ubiquitin ligases ETO1, EOL1 and EOL2 act collectively to regulate ethylene biosynthesis in Arabidopsis by controlling type-2 ACC synthase levels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of ethylene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of ethylene biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ETO1-like 2
    NP_200663.2
    • ETO1-like 2 (EOL2); FUNCTIONS IN: protein binding; INVOLVED IN: regulation of ethylene biosynthetic process; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), BTB/POZ fold (InterPro:IPR011333), BTB/POZ (InterPro:IPR013069), Tetratricopeptide repeat-containing (InterPro:IPR013026), BTB/POZ-like (InterPro:IPR000210), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: tetratricopeptide repeat (TPR)-containing protein (TAIR:AT3G51770.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23665295..23668886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125241.5 → NP_200663.2  ETO1-like 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KF02, Q0WQF6, Q6PWY1, Q9LV01
      Conserved Domains (4) summary
      smart00225
      Location:208 → 303
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00006
      Location:739 → 766
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:739 → 770
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:739 → 798
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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