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    Pon2 paraoxonase 2 [ Mus musculus (house mouse) ]

    Gene ID: 330260, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pon2provided by MGI
    Official Full Name
    paraoxonase 2provided by MGI
    Primary source
    MGI:MGI:106687
    See related
    Ensembl:ENSMUSG00000032667 AllianceGenome:MGI:106687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330405I24Rik
    Summary
    Predicted to enable acyl-L-homoserine-lactone lactonohydrolase activity; arylesterase activity; and protein homodimerization activity. Predicted to be involved in lactone catabolic process and response to toxic substance. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 37.9), liver E14 (RPKM 21.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pon2 in Genome Data Viewer
    Location:
    6 A1; 6 1.99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (5264620..5298408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (5264620..5298345, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene paraoxonase 1 Neighboring gene STARR-seq mESC enhancer starr_15033 Neighboring gene paraoxonase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3642 Neighboring gene STARR-seq mESC enhancer starr_15035 Neighboring gene STARR-positive B cell enhancer ABC_E8094 Neighboring gene STARR-seq mESC enhancer starr_15037 Neighboring gene STARR-seq mESC enhancer starr_15042 Neighboring gene predicted gene, 38762 Neighboring gene STARR-seq mESC enhancer starr_15044 Neighboring gene ankyrin repeat and SOCS box-containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Paraoxonase 2 deficiency in mice alters motor behavior and causes region-specific transcript changes in the brain. Garrick JM, et al. Neurotoxicol Teratol, 2021 Sep-Oct. PMID 34216730, Free PMC Article
    2. Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress. Rosenblat M, et al. Arterioscler Thromb Vasc Biol, 2003 Mar 1. PMID 12615656
    3. Role of PON2 in innate immune response in an acute infection model. Devarajan A, et al. Mol Genet Metab, 2013 Nov. PMID 23911207, Free PMC Article
    4. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Giordano G, et al. Free Radic Biol Med, 2013 May. PMID 23376469, Free PMC Article
    5. Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway. Sulaiman D, et al. J Mol Cell Cardiol, 2019 Apr. PMID 30802459

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription.
      Title: FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription.
    2. Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis.
      Title: Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis.
    3. Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling.
      Title: Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling.
    4. Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain.
      Title: Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain.
    5. Paraoxonase 2 is an ER chaperone that regulates the epithelial Na(+) channel.
      Title: Paraoxonase 2 is an ER chaperone that regulates the epithelial Na(+) channel.
    6. Paraoxonase 2 deficiency in mice alters motor behavior and causes region-specific transcript changes in the brain.
      Title: Paraoxonase 2 deficiency in mice alters motor behavior and causes region-specific transcript changes in the brain.
    7. Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3beta modulation.
      Title: Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3β modulation.
    8. Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis.
      Title: Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis.
    9. PON2 protects against acute myocardial ischemia-reperfusion injury by reducing mitochondrial dysfunction and oxidative stress in cardiomyocytes.
      Title: Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway.
    10. suggesting that PON2 is necessary for proper mitochondrial function
      Title: Paraoxonase 2 prevents the development of heart failure.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC68232

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-L-homoserine-lactone lactonohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-L-homoserine-lactone lactonohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactone catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactone catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to toxic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serum paraoxonase/arylesterase 2
    Names
    A-esterase 2
    aromatic esterase 2
    serum aryldialkylphosphatase 2
    NP_899131.1
    XP_006505185.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183308.3 → NP_899131.1  serum paraoxonase/arylesterase 2

      See identical proteins and their annotated locations for NP_899131.1

      Status: VALIDATED

      Source sequence(s)
      AC023285, AC164289
      Consensus CDS
      CCDS19900.1
      UniProtKB/Swiss-Prot
      Q3TAD3, Q62086, Q8CFK3
      Related
      ENSMUSP00000062670.9, ENSMUST00000057792.9
      Conserved Domains (1) summary
      pfam01731
      Location:167 → 252
      Arylesterase; Arylesterase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      5264620..5298408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505122.3 → XP_006505185.1  serum paraoxonase/arylesterase 2 isoform X1

      Conserved Domains (2) summary
      pfam01731
      Location:81 → 166
      Arylesterase
      pfam08450
      Location:125 → 210
      SGL; SMP-30/Gluconolaconase/LRE-like region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62086.2 GenPept UniProtKB/Swiss-Prot:Q62086

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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