GOLGA1 golgin A1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GOLGA1provided by HGNC
Official Full Name: golgin A1provided by HGNC
Primary source: HGNC:HGNC:4424
See related: Ensembl:ENSG00000136935 MIM:602502; AllianceGenome:HGNC:4424
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: golgin-97
Summary: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [provided by RefSeq, Feb 2010]
Expression: Ubiquitous expression in testis (RPKM 12.9), skin (RPKM 6.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q33.3

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (124878275..124948043, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (137076588..137151003, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (127640554..127703362, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane.
Title: PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane.
Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers.
Title: Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers.
FIP1/RCP binding to Golgin-97 is required for tethering and fusion of recycling endosome-derived retrograde transport vesicles to the trans-Golgi network.
Title: FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network.
Observational study of gene-disease association. (HuGE Navigator)
Title: Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Selective and essential component of the tubulovesicular carriers transporting E-cadherin out of the trans-Golgi network.
Title: E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97.
The ability of the four mammalian GRIP domain proteins, p230, golgin-97, GCC88, and GCC185 to interact is reported.
Title: The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.
Data show that Arl1 regulates the membrane recruitment of Golgin-97, which plays a role in transport from the endosome to the trans-Golgi network.
Title: Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network.
Using RNA interference approach, it was demonstrated that a cellular trans-Golgi network membrane protein, golgin-97, is essential for Vaccinia virus replication.
Title: A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with golgin A1 (GOLGA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-32296 (e-PCR)
- UniSTS:21281

GOLGA1-1 (e-PCR)
- UniSTS:511788

D9S1723 (e-PCR)
- UniSTS:28225

SHGC-4663 (e-PCR)
- UniSTS:82542

SHGC-149475 (e-PCR)
- UniSTS:177027

RH12038 (e-PCR)
- UniSTS:66221

D9S2063 (e-PCR)
- UniSTS:81332

D9S1928 (e-PCR)
- UniSTS:32958

RH79254 (e-PCR)
- UniSTS:21959

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: golgin subfamily A member 1

Names: gap junction protein, alpha 4, 37kD; golgi autoantigen, golgin subfamily a, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002077.4 → NP_002068.2 golgin subfamily A member 1

Status: REVIEWED

Source sequence(s)

AL354928, AL451125

Consensus CDS

CCDS6860.1

UniProtKB/Swiss-Prot

Q5T164, Q8IYZ9, Q92805

UniProtKB/TrEMBL

B4DYI0

Related

ENSP00000362656.4, ENST00000373555.9

Conserved Domains (3) summary

smart00755
Location:692 → 737

Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245

COG1196
Location:249 → 649

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:121 → 447

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

124878275..124948043 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047423242.1 → XP_047279198.1 golgin subfamily A member 1 isoform X1

UniProtKB/Swiss-Prot

Q5T164, Q8IYZ9, Q92805
XM_006717063.5 → XP_006717126.1 golgin subfamily A member 1 isoform X1

See identical proteins and their annotated locations for XP_006717126.1

UniProtKB/Swiss-Prot

Q5T164, Q8IYZ9, Q92805

UniProtKB/TrEMBL

B4DYI0

Conserved Domains (3) summary

smart00755
Location:692 → 737

Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245

COG1196
Location:249 → 649

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:121 → 447

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_005251929.5 → XP_005251986.1 golgin subfamily A member 1 isoform X1

See identical proteins and their annotated locations for XP_005251986.1

UniProtKB/Swiss-Prot

Q5T164, Q8IYZ9, Q92805

UniProtKB/TrEMBL

B4DYI0

Conserved Domains (3) summary

smart00755
Location:692 → 737

Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245

COG1196
Location:249 → 649

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:121 → 447

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006717062.5 → XP_006717125.1 golgin subfamily A member 1 isoform X1

See identical proteins and their annotated locations for XP_006717125.1

UniProtKB/Swiss-Prot

Q5T164, Q8IYZ9, Q92805

UniProtKB/TrEMBL

B4DYI0

Conserved Domains (3) summary

smart00755
Location:692 → 737

Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245

COG1196
Location:249 → 649

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:121 → 447

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_047423241.1 → XP_047279197.1 golgin subfamily A member 1 isoform X1

UniProtKB/Swiss-Prot

Q5T164, Q8IYZ9, Q92805